TLR3 and TLR9 Agonists Improve Postexposure Vaccination Efficacy of Live Smallpox Vaccines

Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses

(2014) Megumi Tatematsu et al.   BIOCHEMICAL JOURNAL

Animal Model of Respiratory Syncytial Virus: CD8+ T Cells Cause a Cytokine Storm That Is Chemically Tractable by Sphingosine-1-Phosphate 1 Receptor Agonist Therapy

(2014) K. B. Walsh et al.   JOURNAL OF VIROLOGY

Rapid Expansion of CD8+ T Cells in Wild-Type and Type I Interferon Receptor-Deficient Mice Correlates with Protection after Low-Dose Emergency Immunization with Modified Vaccinia Virus Ankara

(2014) A. Volz et al.   JOURNAL OF VIROLOGY

TLR3 immunity to infection in mice and humans

(2013) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Pathogen Recognition Receptors: Ligands and Signaling Pathways by Toll-Like Receptors

(2013) Miwa Sasai et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity

(2013) G. L. Smith et al.   JOURNAL OF GENERAL VIROLOGY

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Use of a Recombinant Vaccinia Virus Expressing Interferon Gamma for Post-Exposure Protection against Vaccinia and Ectromelia Viruses

(2013) Susan A. Holechek et al.   PLoS One

Active vaccination with vaccinia virus A33 protects mice against lethal vaccinia and ectromelia viruses but not against cowpoxvirus; elucidation of the specific adaptive immune response

(2013) Nir Paran et al.   Virology Journal

TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models

(2013) Takahiro Tougan et al.   Human Vaccines & Immunotherapeutics

Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system

(2012) Nobutaka Hanagata   International Journal of Nanomedicine

CD8 T Cells Are Essential for Recovery from a Respiratory Vaccinia Virus Infection

(2012) J. Goulding et al.   JOURNAL OF IMMUNOLOGY

Lethal Monkeypox Virus Infection of CAST/EiJ Mice Is Associated with a Deficient Gamma Interferon Response

(2012) P. L. Earl et al.   JOURNAL OF VIROLOGY

Side-by-Side Comparison of Gene-Based Smallpox Vaccine with MVA in Nonhuman Primates

(2012) Joseph W. Golden et al.   PLoS One

Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge

(2012) Yuhong Xiao et al.   VACCINE

A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease

(2012) Tomer Israely et al.   Virology Journal

Antibody Inhibition of a Viral Type 1 Interferon Decoy Receptor Cures a Viral Disease by Restoring Interferon Signaling in the Liver

(2012) Ren-Huan Xu et al.   PLoS Pathogens

Critical Role of Perforin-dependent CD8+ T Cell Immunity for Rapid Protective Vaccination in a Murine Model for Human Smallpox

(2012) Melanie Kremer et al.   PLoS Pathogens

Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

(2011) David N. Taylor et al.   VACCINE

Toll-like receptors: key players in antiviral immunity

(2011) Nicholas Arpaia et al.   Current Opinion in Virology

TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine

(2010) Cevayir Coban et al.   Expert Review of Vaccines

A Mouse Model of Lethal Infection for Evaluating Prophylactics and Therapeutics against Monkeypox Virus

(2010) J. Stabenow et al.   JOURNAL OF VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge

(2010) George W. Buchman et al.   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

The innate immune response to DNA

(2009) Akosua Vilaysane et al.   SEMINARS IN IMMUNOLOGY

A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic

(2009) Yuk-Fai Lau et al.   VACCINE

Effective post-exposure protection against lethal orthopoxviruses infection by vaccinia immune globulin involves induction of adaptive immune response

(2009) Shlomo Lustig et al.   VACCINE

Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine

(2009) Ioanna Skountzou et al.   VACCINE

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

(2009) Christiane Stahl-Hennig et al.   PLoS Pathogens

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

(2008) Christofer Samuelsson et al.   JOURNAL OF CLINICAL INVESTIGATION

The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination

(2008) Ren-Huan Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Postexposure Immunization with Modified Vaccinia Virus Ankara or Conventional Lister Vaccine Provides Solid Protection in a Murine Model of Human Smallpox

(2008) Nir Paran et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of therapeutic intervention with an oral ether–lipid analogue of cidofovir (CMX001) in a lethal mousepox model

(2007) Scott Parker et al.   ANTIVIRAL RESEARCH