Cell Fate Decisions in Malignant Hematopoiesis: Leukemia Phenotype Is Determined by Distinct Functional Domains of the MN1 Oncogene

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

(2013) M. Neumann et al.   BLOOD

Mutations and prognosis in primary myelofibrosis

(2013) A M Vannucchi et al.   LEUKEMIA

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Mapping of MN1 Sequences Necessary for Myeloid Transformation

(2013) Ayten Kandilci et al.   PLoS One

MLL–AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny

(2012) S J Horton et al.   LEUKEMIA

The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo

(2012) A. P. W. Funnell et al.   MOLECULAR AND CELLULAR BIOLOGY

Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

(2012) M Neumann et al.   Blood Cancer Journal

Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia

(2011) S. Schwind et al.   BLOOD

Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells

(2011) Inderdeep S. Kalra et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex

(2011) Michael Heuser et al.   CANCER CELL

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

Gene expression of BAALC, CDKN1B, ERG, and MN1 adds independent prognostic information to cytogenetics and molecular mutations in adult acute myeloid leukemia

(2011) Claudia Haferlach et al.   GENES CHROMOSOMES & CANCER

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation of the human HBA genes by KLF4 in erythroid cell lines

(2010) M. Giuseppina Marini et al.   BRITISH JOURNAL OF HAEMATOLOGY

Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia

(2010) T Liu et al.   LEUKEMIA

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

(2010) Ryan D Morin et al.   NATURE GENETICS

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation

(2009) A. Kandilci et al.   BLOOD

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal

(2009) M. Heuser et al.   BLOOD

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA

(2009) A. K. Burnett et al.   BLOOD

Prognostic Importance ofMN1Transcript Levels, and Biologic Insights FromMN1-Associated Gene and MicroRNA Expression Signatures in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

(2009) Christian Langer et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

arrayQualityMetrics—a bioconductor package for quality assessment of microarray data

(2008) Audrey Kauffmann et al.   BIOINFORMATICS

Loss of Mll5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation

(2008) M. Heuser et al.   BLOOD

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

(2008) Peggy Kirstetter et al.   CANCER CELL

A Fast Thresholded Landweber Algorithm for Wavelet-Regularized Multidimensional Deconvolution

(2008) C. Vonesch et al.   IEEE TRANSACTIONS ON IMAGE PROCESSING