TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-  Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

(2014) R. Higgs et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein

(2013) Na-Rae Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors

(2013) Gijs A. Versteeg et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Novel Function of Trim44 Promotes an Antiviral Response by Stabilizing VISA

(2013) B. Yang et al.   JOURNAL OF IMMUNOLOGY

Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

(2013) Li Zhang et al.   JOURNAL OF LIPID RESEARCH

Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

(2013) William A McEwan et al.   NATURE IMMUNOLOGY

TRIM22 inhibits the TRAF6-stimulated NF-κB pathway by targeting TAB2 for degradation

(2013) Hui Qiu et al.   VIROLOGICA SINICA

TRIM genes are part of the interferon signature observed in patients with primary Sjögren's syndrome

(2012) Maria Sjöstrand et al.   ANNALS OF THE RHEUMATIC DISEASES

TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways

(2012) Takeshi Kondo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation

(2012) Mio Shibata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion

(2012) Yiwei Li et al.   Epigenetics

Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene

(2012) Ken Dutton-Regester et al.   GENES CHROMOSOMES & CANCER

E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I-Mediated IFN-  Production and Antiviral Response by Targeting NAP1

(2012) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

(2012) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

TRIM38 Negatively Regulates TLR3-Mediated IFN-β Signaling by Targeting TRIF for Degradation

(2012) Qinghua Xue et al.   PLoS One

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

(2012) Akshay A. D'Cruz et al.   PROTEIN SCIENCE

Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator

(2011) Shanshan Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

TRIM40 promotes neddylation of IKK  and is downregulated in gastrointestinal cancers

(2011) K. Noguchi et al.   CARCINOGENESIS

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Anaplastic lymphoma kinase as a new target for the treatment of non-small-cell lung cancer

(2011) Marcello Tiseo et al.   Expert Review of Anticancer Therapy

Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination

(2011) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRAF-associated protein TANK facilitates cross-talk within the I B kinase family during Toll-like receptor signaling

(2011) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis

(2011) Kanji Endoh et al.   PROSTATE

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice

(2010) Hui Xiao et al.   GASTROENTEROLOGY

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

(2010) Rowan Higgs et al.   PLoS One

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

(2009) Alexander Espinosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Melanoma Inhibitor of Apoptosis Protein (ML-IAP) Specific Cytotoxic T Lymphocytes Cross-React with an Epitope from the Auto-Antigen SS56

(2009) Rikke Bæk Sørensen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRIM68 Regulates Ligand-Dependent Transcription of Androgen Receptor in Prostate Cancer Cells

(2008) N. Miyajima et al.   CANCER RESEARCH

Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells

(2008) Ricardo Rajsbaum et al.   EUROPEAN JOURNAL OF IMMUNOLOGY