Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

(2014) Monica Bonetti et al.   DEVELOPMENT

PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice

(2014) J. Paardekooper Overman et al.   MOLECULAR AND CELLULAR BIOLOGY

Proteomics Analysis of the Zebrafish Skeletal Extracellular Matrix

(2014) Maurijn Y. Kessels et al.   PLoS One

Gain-of-Function Mutations in RIT1 Cause Noonan Syndrome, a RAS/MAPK Pathway Syndrome

(2013) Yoko Aoki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma

(2013) Deshui Jia et al.   CELL RESEARCH

Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

(2013) Zhi-Hong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zebrafish brain proteomics reveals central proteins involved in neurodegeneration

(2013) Mohammed Gebriel et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

(2013) Pia J. Müller et al.   Journal of Proteomics

Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells

(2012) C Preisinger et al.   LEUKEMIA

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

(2011) V. Runtuwene et al.   Disease Models & Mechanisms

Tyrosine Phosphorylation Profiling in FGF-2 Stimulated Human Embryonic Stem Cells

(2011) Vanessa M. Y. Ding et al.   PLoS One

Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase

(2011) Eva Darian et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Phosphatase-Dependent and -Independent Functions of Shp2 in Neural Crest Cells Underlie LEOPARD Syndrome Pathogenesis

(2010) Rodney A. Stewart et al.   DEVELOPMENTAL CELL

Proteomic Profile of Zebrafish Brain Based on Two-Dimensional Gel Electrophoresis Matrix-Assisted Laser Desorption/Ionization MS/MS Analysis

(2010) Sachin K. Singh et al.   Zebrafish

In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling

(2009) Paul J. Boersema et al.   MOLECULAR & CELLULAR PROTEOMICS

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway

(2009) Isabelle Roszko et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

(2008) Kimihiko Oishi et al.   HUMAN MOLECULAR GENETICS

Noonan Syndrome-associated SHP-2/Ptpn11Mutants Enhance SIRPα and PZR Tyrosyl Phosphorylation and Promote Adhesion-mediated ERK Activation

(2008) Seda Eminaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin

(2008) Seung-Hye Lee et al.   JOURNAL OF CELL BIOLOGY

Comparative Phosphoproteomics of Zebrafish Fyn/Yes Morpholino Knockdown Embryos

(2008) Simone Lemeer et al.   MOLECULAR & CELLULAR PROTEOMICS

An Essential Role for DYF-11/MIP-T3 in Assembling Functional Intraflagellar Transport Complexes

(2008) Chunmei Li et al.   PLoS Genetics