Editorial Material
Oncology
Dominik Wolf, Gottfried Baier
Summary: In preclinical cancer models, the genetic deletion of CBLB gene enhances the resistance of adoptively transferred CD8(+) T cells to regulatory T cells, resulting in a higher efficacy against various cancers.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Silvia Spoerl, Anita N. Kremer, Michael Aigner, Nina Eisenhauer, Pauline Koch, Lina Meretuk, Patrick Loeffler, Matthias Tenbusch, Clara Maier, Klaus Ueberla, Lucie Heinzerling, Benjamin Frey, Gloria Lutzny-Geier, Thomas H. Winkler, Gerhard Kroenke, Marcel Vetter, Heiko Bruns, Markus F. Neurath, Andreas Mackensen, Andreas E. Kremer, Simon Voelkl
Summary: In COVID-19 patients, enhanced NK-/B-cell activation and proliferation were observed regardless of severity, along with a stronger T-cell activation profile. Additionally, higher expression of CCR4 chemokine receptor on T cells in severe COVID-19 patients suggests a potential mechanism for increased immune activation and pulmonary toxicity.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Yun Hua Lee, Samuel Chuah, Phuong H. D. Nguyen, Chun Jye Lim, Hannah L. H. Lai, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Glenn K. Bonney, Chung Yip Chan, Alexander Chung, Brian K. P. Goh, Weiwei Zhai, Pierce K. H. Chow, Salvatore Albani, Haiyan Liu, Valerie Chew
Summary: In this study, IL-17-producing CD8 (Tc17) T cells were found to have distinct immunological phenotypes and regulatory circuits in hepatocellular carcinoma (HCC). The IFN gamma(-) Tc17 subset demonstrated pro-tumoral characteristics and higher expression of CCL20, which was associated with increased tumor infiltration of T regulatory cells (Treg) and poorer prognosis in HCC patients.
Article
Immunology
Ruoyu Chao, Mikako Nishida, Nahoko Yamashita, Miho Tokumasu, Weiyang Zhao, Ikuru Kudo, Heiichiro Udono
Summary: Metformin enhances IFNγ production by CD8(+) T cells through differential metabolic pathways and nutrient conditions, suggesting its potential application in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Ying Lu, Ming-Xu Zhang, Wei Pang, Tian-Zhang Song, Hong-Yi Zheng, Ren-Rong Tian, Yong-Tang Zheng
Summary: This study reveals the molecular mechanism underlying the difference in progression rate between rapid and slow progressors in HIV patients, shedding light on the complexity of disease progression.
Article
Multidisciplinary Sciences
Marie Boutet, Zachary Benet, Erik Guillen, Caroline Koch, Saidi M'Homa Soudja, Fabien Delahaye, David Fooksman, Gregoire Lauvau
Summary: Research shows that rapid and effective CD8(+) T cell responses require spatially and temporally coordinated events, delivering activating chemokines locally to CCR2(+)Ly6C(+) monocytes to quickly restrict microbial pathogen growth. CD8(+) T cells recognize cognate antigen on dendritic cells, initiating a burst of chemokines production and delivering IFN gamma and chemokines to CCR2(+)Ly6C(+) monocytes for microbicidal activities.
Article
Multidisciplinary Sciences
Karen Geoffroy, Bruna Araripe Saraiva, Melissa Viens, Delphine Beland, Marie-Claude Bourgeois-Daigneault
Summary: Proteasome dependency is a common characteristic in many cancers that can be targeted with proteasome inhibitors. A modified form of the proteasome called the immunoproteasome (ImP) has been associated with better outcomes in breast cancer, particularly triple-negative breast cancer (TNBC). However, there is a lack of studies on ImP expression at the protein level in large patient cohorts, and the cellular source of ImPs is often overlooked. The findings from our study suggest that high expression of ImP by tumor cells may serve as a prognostic marker for TNBC outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
SeongJun Han, Zhe Qi Liu, Douglas C. Chung, Michael St Paul, Carlos R. Garcia-Batres, Azin Sayad, Alisha R. Elford, Matthew J. Gold, Natasha Grimshaw, Pamela S. Ohashi
Summary: This study investigated the role of Cbl-b in enhancing CD8(+) T-cell resistance to Treg-mediated suppression and its impact on antitumor immunity. It was found that the hypersecretion of IFN gamma by Cbl-b-deficient CD8(+) T cells attenuated Treg-induced suppression and had profound effects on CD8(+) T cells. The study demonstrated that Cbl-b-deficient CD8(+) T cells elicited a superior antitumor immune response in murine models.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Hee Yeun Won, Nurcin Liman, Can Li, Jung-Hyun Park
Summary: Innate CD8 T cells are inflammatory effector T cells that mature in the thymus and enter peripheral tissues. They produce the Th1 cytokine IFN gamma and depend on the Th2 cytokine IL-4 for their generation. IL-4 is produced by the NKT2 subset of iNKT cells, and NKT2 deficiency leads to the absence of innate CD8 T cells. However, it is not clear if NKT2 is the only iNKT subset and if IL-4 is the only cytokine required for the generation of innate CD8 T cells. This study shows that IL-4, not IFN gamma, is the key regulator of innate CD8 T cell generation in the thymus.
Article
Cell Biology
Leonard R. Pelgrom, Thiago A. Patente, Frank Otto, Lonneke V. Nouwen, Arifa Ozir-Fazalalikhan, Alwin J. van der Ham, Hendrik J. P. van der Zande, Graham A. Heieis, Ramon Arens, Bart Everts
Summary: This study reveals that mTORC1 limits the activation of CD8(+) T cells in vivo by regulating the metabolism and immunogenicity of different subsets of antigen-presenting cells, but it does not affect antigen-specific CD8(+) T cell responses to infection.
Article
Immunology
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmueller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Summary: Bedoui and colleagues discovered a sequential integration process in APCs that enhances their ability to activate antiviral CD8(+) T cell responses. This process involves the gradual induction of specific transcriptional regulators and co-stimulatory molecules, led by CD4(+) T cell-mediated CD40 stimulation and interferon-alpha/interferon-beta activation. These findings highlight the importance of APC-T cell interactions in antiviral immunity.
Article
Medicine, Research & Experimental
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Summary: We investigated the differential impact of myeloid subsets on immunity to pancreatic ductal adenocarcinoma (PDA). Our study demonstrates that tumor antigenicity shapes the composition and functionality of myeloid cells. The therapeutic effectiveness of adoptive T cell therapy or programmed cell death ligand 1 blockade relies on the presence of type 1 dendritic cells (cDC1), which support the survival and function of antitumor T cells. Our research highlights the essential role of cDC1s in sustaining effective antitumor T cells and reveals differential roles for cDC1s and monocytes/macrophages in guiding T cell fate and immunotherapy response.
Article
Multidisciplinary Sciences
Diego Calzada-Fraile, Salvador Iborra, Marta Ramirez-Huesca, Inmaculada Jorge, Enrico Dotta, Elena Hernandez-Garcia, Noa Martin-Cofreces, Estanislao Nistal-Villan, Esteban Veiga, Jesus Vazquez, Giulia Pasqual, Francisco Sanchez-Madrid
Summary: Antigen presentation induces upregulation of MHC-I protein molecules and increased lipid peroxidation on psDCs, mediating DC licensing. Adoptive transfer of psDC enhances pathogen-specific CD8(+) T cell responses and protects mice from infection. The study reveals crucial molecular events underlying psDC licensing.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Chun-I. Wang, Yi-Fang Chang, Zong-Lin Sie, Ai-Sheng Ho, Jung-Shan Chang, Cheng-Liang Peng, Chun-Chia Cheng
Summary: This study revealed the mechanism of radiotherapy inhibiting IFN gamma-mediated gene expression and enhancing immune surveillance.
Article
Multidisciplinary Sciences
Nadine Kamenjarin, Katrin Hodapp, Felix Melchior, Gregory Harms, Ann- Kathrin Hartmann, Joschka Bartneck, Sabine Muth, Verena K. Raker, Christian Becker, Anna Brand, Bjorn E. Clausen, Markus P. Radsak, Hansjorg Schild, Hans Christian Probst
Summary: Tissue-resident memory CD8+ T cells (TRM) in the skin require epidermal Langerhans cells, which cross-present keratinocyte-derived antigens, for their reactivation to provide protection against reinfection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Rheumatology
Goitybell Martinez, Jorge A. Gomez, Holger Bang, Lorena Martinez-Gamboa, Dirk Roggenbuck, Gerd-Ruediger Burmester, Barbara Torres, Dinorah Prada, Eugen Feist
RHEUMATOLOGY INTERNATIONAL
(2016)
Article
Clinical Neurology
Elena Ikenberg, Ivan Karin, Birgit Ertl-Wagner, Angela Abicht, Stefanie Bulst, Krause Sabine, Benedikt Schoser, Peter Reilich, Maggie C. Walter
NEUROMUSCULAR DISORDERS
(2017)
Letter
Clinical Neurology
Ursula R. Moore, Marni Jacobs, Roberto Fernandez-Torron, Jiji Jang, Meredith K. James, Anna Mayhew, Laura Rufibach, Plavi Mittal, Michelle Eagle, Avital Cnaan, Pierre G. Carlier, Andrew Blamire, Heather Hilsden, Hanns Lochmueller, Ulrike Grieben, Simone Spuler, Carolina Tesi Rocha, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Matthew Harms, Alan Pestronk, Sabine Krause, Olivia Schreiber-Katz, Maggie C. Walter, Carmen Paradas, Jean-Yves Hogrel, Tanya Stojkovic, Shin'ichi Takeda, Madoka Mori-Yoshimura, Elena Bravver, Susan Sparks, Jordi Diaz-Manera, Luca Bello, Claudio Semplicini, Elena Pegoraro, Jerry R. Mendell, Kate Bushby, Volker Straub
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)
Article
Clinical Neurology
Ursula Moore, Marni Jacobs, Meredith K. James, Anna G. Mayhew, Roberto Fernandez-Torron, Jia Feng, Avital Cnaan, Michelle Eagle, Karen Bettinson, Laura E. Rufibach, Robert Muni Lofra, Andrew M. Blamire, Pierre G. Carlier, Plavi Mittal, Linda Pax Lowes, Lindsay Alfano, Kristy Rose, Tina Duong, Katherine M. Berry, Elena Montiel-Morillo, Irene Pedrosa-Hernandez, Scott Holsten, Mohammed Sanjak, Ai Ashida, Chikako Sakamoto, Takayuki Tateishi, Hiroyuki Yajima, Aurelie Canal, Gwenn Ollivier, Valerie Decostre, Juan Bosco Mendez, Nieves Sanchez-Aguilera Praxedes, Simone Thiele, Catherine Siener, Jeanine Shierbecker, Julaine M. Florence, Bruno Vandevelde, Brittney DeWolf, Meghan Hutchence, Richard Gee, Juliana Pruegel, Elke Maron, Heather Hilsden, Hanns Lochmueller, Ulrike Grieben, Simone Spuler, Carolina Tesi Rocha, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Matthew Harms, Alan Pestronk, Sabine Krause, Olivia Schreiber-Katz, Maggie C. Walter, Carmen Paradas, Jean-Yves Hogrel, Tanya Stojkovic, Shin'ichi Takeda, Madoka Mori-Yoshimura, Elena Bravver, Susan Sparks, Jordi Diaz-Manera, Luca Bello, Claudio Semplicini, Elena Pegoraro, Jerry R. Mendell, Kate Bushby, Volker Straub, Adrienne Arrieta, Esther Hwang, Elaine Lee, Isabel Illa, Eduard Gallardo, Izaskun Belmonte Jimeno, Jaume Llauger Rossello, Bruce Harwick, Jackie Sykes, Brent Yetter, Mark Smith, Bernard Lapeyssonie, David Bendahan, Yann Le Fur, Attarian Shahram, Testot-Ferry Albane, Eva M. Coppenrath, Elizabeth Harris, Michela Guglieri, Teresinha Evangelista, Alex Murphy, Dionne Moat, Tim Hodgson, Dorothy Wallace, Louise Ward, Debra Galley, Chiara Calore, Roberto Stramare, Alessandro Rampado, Teresa Gidaro, Suna Turk, Laurent Servais, Cyrille Theis, Oumar Diabate, Linda Schimmoeller, Glenn Foster, Pilar Carbonell, Macarena Cabrera, Yolanda Morgado, Susana Rico Gala, Jennifer Perez, Anne Marie Sawyer, Nigel F. Clarke, Sarah Sandaradura, Roula Ghaoui, Kayla Cornett, Claire Miller, Sheryl Foster, Anthony Peduto, Noriko Sato, Takeshi Tamaru, Yoko Kobayashi, Ai Ashida, Takahiro Nakayama, Kazuhiko Segawa, Sachiko Ohtaguro, Harumasa Nakamura, Maki Ohhata, En Kimura, Makiko Endo, Nora Brody, Meganne E. Leach, Allyn Toles, Stanley T. Fricke, Hansel J. Otero
Article
Clinical Neurology
Elisabeth Schorling, Simone Thiele, Laura Gumbert, Sabine Krause, Constanze Klug, Olivia Schreiber-Katz, Peter Reilich, Klaus Nagels, Maggie C. Walter
Article
Biochemistry & Molecular Biology
A. Moretti, L. Fonteyne, F. Giesert, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, T. Froehlich, F. Abdel Rahman, T. Haufe, S. Sun, V. Jurisch, B. Kessler, R. Hinkel, R. Dirschinger, E. Martens, C. Jilek, A. Graf, S. Krebs, G. Santamaria, M. Kurome, V. Zakhartchenko, B. Campbell, K. Voelse, A. Wolf, T. Ziegler, S. Reichert, S. Lee, F. Flenkenthaler, T. Dorn, I. Jeremias, H. Blum, A. Dendorfer, A. Schnieke, S. Krause, M. C. Walter, N. Klymiuk, K. L. Laugwitz, E. Wolf, W. Wurst, C. Kupatt
Article
Biochemistry & Molecular Biology
Nisha Verwey, Isabella Gazzoli, Sabine Krause, Kamel Mamchaoui, Vincent Mouly, Annemieke Aartsma-Rus
NUCLEIC ACID THERAPEUTICS
(2020)
Article
Endocrinology & Metabolism
Guido Vogt, Naji El Choubassi, Agnes Herczegfalvi, Heike Koelbel, Anja Lekaj, Ulrike Schara, Manuel Holtgrewe, Sabine Krause, Rita Horvath, Markus Schuelke, Christoph Hubner, Stefan Mundlos, Andreas Roos, Hanns Lochmueller, Veronika Karcagi, Uwe Kornak, Bjoern Fischer-Zirnsak
Summary: This study identified pathogenic variants in ATP6V1A as the cause of autosomal recessive cutis laxa type 2D (ARCL2D). The affected individuals showed severe cutis laxa at birth, with some passing away in infancy and others now being adolescents with mild or absent intellectual disability. Functional studies revealed cellular abnormalities in fibroblasts, highlighting the clinical variability of ATP6V1A related phenotypes even within the same family.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Christoph H. Emmerich, Lorena Martinez Gamboa, Martine C. J. Hofmann, Marc Bonin-Andresen, Olga Arbach, Pascal Schendel, Bjoern Gerlach, Katja Hempel, Anton Bespalov, Ulrich Dirnagl, Michael J. Parnham
Summary: Academic research plays a crucial role in identifying new drug targets, and this Perspective introduces a framework to assist academic scientists and funders in prioritizing target assessment activities to achieve scientific goals and objectives related to licensing, industry collaboration, and clinical trials.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Biology
Natascha Ingrid Drude, Lorena Martinez Gamboa, Meggie Danziger, Ulrich Dirnagl, Ulf Toelch
Summary: The purpose of preclinical research is to guide the development of novel diagnostics or therapeutics, with results from animal models informing decisions on human studies. Despite apparent efficacy demonstrated in preclinical studies, a significant number of clinical trials still fail. Large-scale replication studies are currently investigating factors influencing the robustness of preclinical research.
Review
Medicine, Research & Experimental
Suzan M. Hammond, Annemieke Aartsma-Rus, Sandra Alves, Sven E. Borgos, Ronald A. M. Buijsen, Rob W. J. Collin, Giuseppina Covello, Michela A. Denti, Lourdes R. Desviat, Lucia Echevarria, Camilla Foged, Gisela Gaina, Alejandro Garanto, Aurelie T. Goyenvalle, Magdalena Guzowska, Irina Holodnuka, David R. Jones, Sabine Krause, Taavi Lehto, Marisol Montolio, Willeke Van Roon-Mom, Virginia Arechavala-Gomeza
Summary: The field of nucleic acid-based therapeutics has seen rapid development in recent years, with the main challenge being delivery to target tissues. The adoption of delivery technologies, such as conjugates or nanoparticles, has been a game changer for many therapeutic indications.
EMBO MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Maggie C. Walter, Peter Reilich, Sabine Krause, Miriam Hiebeler, Stefanie Gehling, Hans H. Goebel, Benedikt Schoser, Angela Abicht
Summary: This study reports on an adult Turkish patient with mild myopathy, fiber-type disproportion, and mitochondrial disorganization caused by genetic variants in the plectin gene. Two unknown significance variants were identified through molecular genetic panel testing, and the patient also exhibited mild skin blistering.
NEUROMUSCULAR DISORDERS
(2021)
Editorial Material
Biology
Natascha Drude, Lorena Martinez-Gamboa, Tamarinde Haven, Constance Holman, Martin Holst, Silke Kniffert, Sarah McCann, Torsten Rackoll, Robert Schulz, Sarah Weschke
Summary: Improving the reproducibility and trustworthiness of biomedical research requires engaging stakeholders at all levels. The QUEST Center for Responsible Research aims to develop and implement new approaches to improve research culture and practice, tailored to stakeholder needs. By sharing lessons from working groups, the authors highlight common themes that have influenced the success of many projects.
BMC RESEARCH NOTES
(2022)
Article
Rheumatology
Pedro Lopez-Romero, Lorena Martinez-Gamboa, Holger Bang, Inmaculada de la Torre, Thorsten Holzkamper, Eugen Feist
ARTHRITIS RESEARCH & THERAPY
(2020)
Article
Clinical Neurology
Jordi Diaz-Manera, Roberto Fernandez-Torron, Jaume LLauger, Meredith K. James, Anna Mayhew, Fiona E. Smith, Ursula R. Moore, Andrew M. Blamire, Pierre G. Carlier, Laura Rufibach, Plavi Mittal, Michelle Eagle, Marni Jacobs, Tim Hodgson, Dorothy Wallace, Louise Ward, Mark Smith, Roberto Stramare, Alessandro Rampado, Noriko Sato, Takeshi Tamaru, Bruce Harwick, Susana Rico Gala, Suna Turk, Eva M. Coppenrath, Glenn Foster, David Bendahan, Yann Le Fur, Stanley T. Fricke, Hansel Otero, Sheryl L. Foster, Anthony Peduto, Anne Marie Sawyer, Heather Hilsden, Hanns Lochmuller, Ulrike Grieben, Simone Spuler, Carolina Tesi Rocha, John W. Day, Kristi J. Jones, Diana X. Bharucha-Goebel, Emmanuelle Salort-Campana, Matthew Harms, Alan Pestronk, Sabine Krause, Olivia Schreiber-Katz, Maggie C. Walter, Carmen Paradas, Jean-Yves Hogrel, Tanya Stojkovic, Shin'ichi Takeda, Madoka Mori-Yoshimura, Elena Bravver, Susan Sparks, Luca Bello, Claudio Semplicini, Elena Pegoraro, Jerry R. Mendell, Kate Bushby, Volker Straub
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2018)