TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

Randomised clinical trial: the effects of daikenchuto, TU-100, on gastrointestinal and colonic transit, anorectal and bowel function in female patients with functional constipation

(2013) J. Iturrino et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Attenuation of Proinflammatory Responses byS-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells

(2013) Xiao-Hong Li et al.   Evidence-based Complementary and Alternative Medicine

Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions

(2013) Zhiyu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Daikenchuto, a traditional Japanese herbal medicine, ameliorates postoperative ileus by anti-inflammatory action through nicotinic acetylcholine receptors

(2013) Mari Endo et al.   JOURNAL OF GASTROENTEROLOGY

Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells

(2013) Atsushi Kaneko et al.   Gastroenterology Research and Practice

Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine

(2012) Toru Kono et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Feeding Administration of Daikenchuto Suppresses Colitis Induced by Naive CD4+ T Cell Transfer into SCID Mice

(2012) Tsutomu Iwasa et al.   DIGESTIVE DISEASES AND SCIENCES

Enzymatic Biotransformation of Ginsenoside Rb1 to Compound K by Recombinant β-Glucosidase from Microbacterium esteraromaticum

(2012) Lin-Hu Quan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol

(2012) Chia-Jui Weng et al.   MOLECULAR NUTRITION & FOOD RESEARCH

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

(2012) Xiaojie Wang et al.   PLoS One

Inhibitory Effect of [6]-Gingerol on Melanogenesis in B16F10 Melanoma Cells and a Possible Mechanism of Action

(2011) Huey-Chun HUANG et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Pharmacokinetics of Daikenchuto, a Traditional Japanese Medicine (Kampo) after Single Oral Administration to Healthy Japanese Volunteers

(2011) M. Munekage et al.   DRUG METABOLISM AND DISPOSITION

Bioconversion of ginsenosides Rb1, Rb2, Rc and Rd by novel β-glucosidase hydrolyzing outer 3-O glycoside from Sphingomonas sp. 2F2: Cloning, expression, and enzyme characterization

(2011) Liang Wang et al.   JOURNAL OF BIOTECHNOLOGY

Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn’s disease rat model

(2011) Toru Kono et al.   JOURNAL OF GASTROENTEROLOGY

Kampo medicine “Dai-kenchu-to” prevents CPT-11-induced small-intestinal injury in rats

(2011) Motoya Chikakiyo et al.   SURGERY TODAY

Profiling of the Compounds Absorbed in Human Plasma and Urine after Oral Administration of a Traditional Japanese (Kampo) Medicine, Daikenchuto

(2010) J. Iwabu et al.   DRUG METABOLISM AND DISPOSITION

6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice

(2010) Hou Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epithelial NF-κB Enhances Transmucosal Fluid Movement by Altering Tight Junction Protein Composition after T Cell Activation

(2009) Yueming Tang et al.   AMERICAN JOURNAL OF PATHOLOGY

Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels

(2009) CE Riera et al.   BRITISH JOURNAL OF PHARMACOLOGY

6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT/mTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells

(2009) Jen-Yu Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model

(2009) Toru Kono et al.   Journal of Crohns & Colitis

Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol

(2009) Swarnalatha Dugasani et al.   JOURNAL OF ETHNOPHARMACOLOGY

Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: Is it time yet?

(2009) Toru Kono et al.   SURGERY

American ginseng suppresses inflammation and DNA damage associated with mouse colitis

(2008) Yu Jin et al.   CARCINOGENESIS

Colonic Vascular Conductance Increased by Daikenchuto via Calcitonin Gene-Related Peptide and Receptor-Activity Modifying Protein 1

(2008) Toru Kono et al.   JOURNAL OF SURGICAL RESEARCH

6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages

(2008) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH