Journal
SURGERY TODAY
Volume 42, Issue 1, Pages 60-67Publisher
SPRINGER
DOI: 10.1007/s00595-011-0014-7
Keywords
Dai-kenchu-to; Intestinal injury; CPT-11; Inflammatory cytokine; Apoptosis
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Funding
- Grants-in-Aid for Scientific Research [22591489] Funding Source: KAKEN
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The key anticancer agent, CPT-11 (irinotecan hydrochloride), induces severe diarrhea clinically. We investigated the effect of a Kampo medicine, Dai-kenchu-to (DKT), on CPT-11-induced intestinal injuries in rats. Twenty-four male Wistar rats were divided into three groups: a control group; a CPT-11 group, given CPT-11 150 mg/kg intraperitoneally for 2 days; and a DKT group, given DKT 300 mg/kg orally for 5 days with CPT-11 150 mg/kg intraperitoneally on days 4 and 5. The rats were killed on day 6. Interleukin (IL)-1 beta, IL-12, interferon (IFN)-gamma, and tumor necrosis factor-alpha expression in the small intestine of the CPT-11 group was significantly higher than that of the control group. Interleukin-1 beta and IFN-gamma expression was improved significantly by DKT (P < 0.05). The number and height of jejuna villi, injury score, and apoptosis index in the CPT-11 group were improved significantly by DKT (P < 0.05). DKT suppressed CPT-11 induced inflammatory cytokines and apoptosis in the intestinal mucosa and maintained the mucosal integrity.
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