Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

Fenofibrate lowers lipid accumulation in myotubes by modulating the PPARα/AMPK/FoxO1/ATGL pathway

(2012) Wei-Lu Chen et al.   BIOCHEMICAL PHARMACOLOGY

Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance

(2012) David D. Moore   Cell Metabolism

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver

(2011) Marcin Buler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α pathway

(2011) Hyun Wha Chung et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms

(2010) Bruce C. Frier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells

(2010) David Álvarez-Guardia et al.   CARDIOVASCULAR RESEARCH

Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation

(2010) M. Murea et al.   Clinical Journal of the American Society of Nephrology

New pharmacological treatments for improving renal outcomes in diabetes

(2010) Anne-Emilie Declèves et al.   Nature Reviews Nephrology

The role of FOXO in the regulation of metabolism

(2009) Danielle N. Gross et al.   Current Diabetes Reports

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats

(2009) Seok Joon Shin et al.   HYPERTENSION RESEARCH

Mutual Dependence of Foxo3a and PGC-1α in the Induction of Oxidative Stress Genes

(2009) Yolanda Olmos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

A PGC-1α-O-GlcNAc Transferase Complex Regulates FoxO Transcription Factor Activity in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARα activators upregulate eNOS activity and inhibit cytokine-induced NF-κB activation through AMP-activated protein kinase activation

(2008) Toshie Okayasu et al.   LIFE SCIENCES

ERRα: a metabolic function for the oldest orphan

(2008) Josep A. Villena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM