Review
Biochemistry & Molecular Biology
Claire Y. Li, Stav Brown, Babak J. Mehrara, Raghu P. Kataru
Summary: The lymphatic system plays a crucial role in tumor growth and immune response. Understanding the complex interactions between lymphatic vessels, tumor cells, and the tumor microenvironment can lead to the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ye Jin, Jianming Xing, Kejin Xu, Da Liu, Yue Zhuo
Summary: Exosomes, produced by endosomes, play a crucial role in intercellular communication. Over the past few decades, there has been growing recognition of the importance of exosomes in the tumor microenvironment and their connection to cancer development. This paper discusses the composition, generation, uptake, and roles of exosomes in tumor metastasis, angiogenesis, and immunosuppression. Understanding the biological characteristics of exosomes and their functions in tumor development is significant for identifying new diagnostic biomarkers and therapeutic targets for cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Chunxiang Feng, Zhiyong Xiong, Cheng Wang, Wen Xiao, Haibing Xiao, Kairu Xie, Ke Chen, Huageng Liang, Xiaoping Zhang, Hongmei Yang
Summary: The novel exosome-based drug delivery system designed in this study effectively degrades high molecular weight hyaluronan and modifies the immune microenvironment, reducing tumor cell metastasis.
BIOACTIVE MATERIALS
(2021)
Review
Cell Biology
Jenniffer Linares, Juan A. Marin-Jimenez, Jordi Badia-Ramentol, Alexandre Calon
Summary: Multiple lines of evidence suggest that cancer development and malignant progression are influenced not only by cancer cell-autonomous processes but also by interactions with the tumor microenvironment, particularly through cancer-associated fibroblasts (CAFs) that regulate key mechanisms during metastasis and treatment response. Recent advances in CAFs biology highlight the potential of CAFs-secreted factors as druggable targets and biomarkers for cancer diagnosis and prognosis, paving the way for further research and clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Marie-Anne Goyette, Islam E. Elkholi, Chloe Apcher, Hellen Kuasne, Carla Rothlin, William J. Muller, Darren E. Richard, Morag Park, Jean-Philippe Gratton, Jean-Francois Cote
Summary: Inhibition of Axl leads to reduction of hypoxia-induced EMT, invasion, and cytokine production, creating a favorable environment for immunotherapy and reducing metastatic burden in HER2(+) breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Roberto Coppo, Francesca Orso, Federico Virga, Alberto Dalmasso, Desiree Baruffaldi, Lei Nie, Fabiana Clapero, Daniela Dettori, Lorena Quirico, Elena Grassi, Paola Defilippi, Paolo Provero, Donatella Valdembri, Guido Serini, Mehran M. Sadeghi, Massimiliano Mazzone, Daniela Taverna
Summary: ESDN plays a critical role in melanoma progression by regulating the expression of E-selectin in endothelial cells, affecting melanoma cell adhesion, extravasation, and metastasis formation. The study proposes a protective role for ESDN in melanoma spread and highlights its therapeutic potential.
Review
Oncology
Rushikesh S. Joshi, Samanvi S. Kanugula, Sweta Sudhir, Matheus P. Pereira, Saket Jain, Manish K. Aghi
Summary: The review discusses the importance of cancer-associated fibroblasts (CAFs) in various cancer contexts as potential therapeutic targets. Identification of CAFs and understanding their role in promoting tumor progression may lead to the development of novel cancer therapies.
Article
Biochemistry & Molecular Biology
Tomoaki Hirashima, Hideaki Karasawa, Takashi Aizawa, Takashi Suzuki, Akihiro Yamamura, Hideyuki Suzuki, Taiki Kajiwara, Hiroaki Musha, Ryo Funayama, Matsuyuki Shirota, Shinobu Ohnuma, Keiko Nakayama, Michiaki Unno
Summary: The study reveals that cancer-associated fibroblasts with increased expression of Wnt5a play a crucial role in the progression of colorectal cancer, and may serve as a target for anti-cancer therapies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Huawei Xu, Zhibin Hao, Yujie Wang, Deng Zhang, Jie Li, Ling Chen, Ninghua Yao, Binbin Qian, Xiaobo Peng, Xianbao Zhan
Summary: Gastric cancer, a prevalent tumor globally, is often fatal due to peritoneal metastasis. However, the underlying mechanism of peritoneal metastasis remains unclear. Our study using organoids derived from malignant ascites of gastric cancer patients revealed that the interaction between exfoliated cancer cells and the liquid tumor microenvironment plays a crucial role in peritoneal metastasis.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Orit Adir, Orit Sagi-Assif, Tsipi Meshel, Shlomit Ben-Menachem, Metsada Pasmanik-Chor, Dave S. B. Hoon, Isaac P. Witz, Sivan Izraely
Summary: Brain metastatic melanoma cells reprogram microglia and upregulate JunB expression. High-JunB microglia promote tumor progression, while low-JunB microglia inhibit tumor progression.
Article
Multidisciplinary Sciences
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Summary: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. The characterization of a human IBC cell line in this study suggests that the high level of CCL2 is implicated in macrophage infiltration and tumor progression.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Julio Cesar Villegas-Pineda, Melida del Rosario Lizarazo-Taborda, Adrian Ramirez-de-Arellano, Ana Laura Pereira-Suarez
Summary: The tumor microenvironment consists of molecular and cellular components, with ncRNAs playing a key role in modulating the development of cancer. Communication between different cell types within the tumor microenvironment through exosomal vesicles influences the behavior of tumor cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Huogang Wang, Mingo M. H. Yung, Hextan Y. S. Ngan, Karen K. L. Chan, David W. Chan
Summary: Metastasis, driven by tumor-associated macrophages (TAMs), is a key factor in most cancer deaths, with TAMs playing a crucial role in influencing tumor metastasis and treatment outcomes by polarizing metabolism patterns. Tumor cell-driven TAMs in the tumor microenvironment promote tumor metastasis and are associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Bikash Chandra Jena, Lipsa Rout, Ankita Dey, Mahitosh Mandal
Summary: Autophagy plays a crucial role in cancer cells, particularly in cancer-associated fibroblasts, where it not only provides nutrients and protection but also promotes cancer progression. Targeting autophagy in CAFs has become a significant focus in cancer treatment.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Jun Li, Dawei Chen, Minhong Shen
Summary: The gut microbiota and host cellular and non-cellular components play important roles in the progression and metastasis of colorectal cancer (CRC), and may be targeted for TME-remodeling therapies.
FRONTIERS IN MEDICINE
(2022)