Natural Compounds' Activity against Cancer Stem-Like or Fast-Cycling Melanoma Cells

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

(2014) Sudha Mannava et al.   CELL CYCLE

Parthenolide enhances dacarbazine activity against melanoma cells

(2013) Kamila Koprowska et al.   ANTI-CANCER DRUGS

HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors

(2013) A. Gabrielle J. van der Kraan et al.   BIOCHEMICAL JOURNAL

Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway

(2013) Mohammad Zahid Kamran et al.   BIOMEDICINE & PHARMACOTHERAPY

Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres

(2013) Malgorzata Czyz et al.   CANCER BIOLOGY & THERAPY

Directed Phenotype Switching as an Effective Antimelanoma Strategy

(2013) Magalí Sáez-Ayala et al.   CANCER CELL

Analysis of the Genome-Wide DNA Methylation Profile of Side Population Cells in Hepatocellular Carcinoma

(2013) Jing-Ming Zhai et al.   DIGESTIVE DISEASES AND SCIENCES

Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma

(2013) Zu-Yau Lin et al.   LIFE SCIENCES

Stem cells and targeted approaches to melanoma cure

(2013) George F. Murphy et al.   MOLECULAR ASPECTS OF MEDICINE

Use of Natural Products as Chemical Library for Drug Discovery and Network Pharmacology

(2013) Jiangyong Gu et al.   PLoS One

IMD-0354 Targets Breast Cancer Stem Cells: A Novel Approach for an Adjuvant to Chemotherapy to Prevent Multidrug Resistance in a Murine Model

(2013) Azucena Gomez-Cabrero et al.   PLoS One

Targeting c-MYC with T-Cells

(2013) Florian Helm et al.   PLoS One

BCL2A1is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

(2013) Rizwan Haq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical evaluation of the antimetastatic efficacy of Pentoxifylline on A375 human melanoma cell line

(2012) Mohammed Zahid Kamran et al.   BIOMEDICINE & PHARMACOTHERAPY

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells

(2012) Kaori Toyomura et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Sphere formation and self-renewal capacity of melanoma cells is affected by the microenvironment

(2012) Malgorzata Sztiller-Sikorska et al.   MELANOMA RESEARCH

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

(2012) S M Kumar et al.   ONCOGENE

Analysis of Marker-Defined HNSCC Subpopulations Reveals a Dynamic Regulation of Tumor Initiating Properties

(2012) Paloma Bragado et al.   PLoS One

Small Molecule Antagonists of the Wnt/Beta-Catenin Signaling Pathway Target Breast Tumor-Initiating Cells in a Her2/Neu Mouse Model of Breast Cancer

(2012) Robin M. Hallett et al.   PLoS One

Melanoma Chemotherapy Leads to the Selection of ABCB5-Expressing Cells

(2012) Marine Chartrain et al.   PLoS One

Interaction of Rio1 Kinase with Toyocamycin Reveals a Conformational Switch That Controls Oligomeric State and Catalytic Activity

(2012) Irene N. Kiburu et al.   PLoS One

Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways

(2012) Xue-mei Chen et al.   TOXICOLOGY IN VITRO

Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity

(2012) S Akunuru et al.   Cell Death & Disease

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

(2012) M Ri et al.   Blood Cancer Journal

Streptonigrin inhibits β-Catenin/Tcf signaling and shows cytotoxicity in β-catenin-activated cells

(2011) Seyeon Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Enhancement of HLA class II-restricted CD4+ T cell recognition of human melanoma cells following treatment with bryostatin-1

(2011) Dan Zhao et al.   CELLULAR IMMUNOLOGY

SAR3419: An Anti-CD19-Maytansinoid Immunoconjugate for the Treatment of B-Cell Malignancies

(2011) V. Blanc et al.   CLINICAL CANCER RESEARCH

Cancer Cells Cyclically Lose and Regain Drug-Resistant Highly Tumorigenic Features Characteristic of a Cancer Stem-like Phenotype

(2011) K. He et al.   MOLECULAR CANCER THERAPEUTICS

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway

(2011) I. Nakano et al.   NEURO-ONCOLOGY

A picture of Mitf in melanoma immortality

(2011) C R Goding   ONCOGENE

Inverse expression states of the BRN2 and MITF transcription factors in melanoma spheres and tumour xenografts regulate the NOTCH pathway

(2011) A E Thurber et al.   ONCOGENE

Melanoma Spheroids Grown Under Neural Crest Cell Conditions Are Highly Plastic Migratory/Invasive Tumor Cells Endowed with Immunomodulator Function

(2011) Kiran Ramgolam et al.   PLoS One

β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance

(2011) Tobias Sinnberg et al.   PLoS One

Identification of Cytotoxic Drugs That Selectively Target Tumor Cells with MYC Overexpression

(2011) Anna Frenzel et al.   PLoS One

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells

(2011) Kenneth C. Valkenburg et al.   Cancers

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Novel anticancer compounds induce apoptosis in melanoma cells

(2010) Uppoor G. Bhat et al.   CELL CYCLE

Pentoxifylline Inhibits Integrin-Mediated Adherence of 12(S)-HETE and TNFα-Activated B16F10 Cells to Fibronectin and Endothelial Cells

(2010) Meenakashi Jain et al.   CHEMOTHERAPY

The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells

(2010) Marco Garate et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2) –Positive Breast Cancer After Prior HER2-Directed Therapy

(2010) Howard A. Burris et al.   JOURNAL OF CLINICAL ONCOLOGY

Heterogeneous Phenotype of Human Melanoma Cells with In Vitro and In Vivo Features of Tumor-Initiating Cells

(2010) Michela Perego et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

(2010) D. Kuck et al.   MOLECULAR CANCER THERAPEUTICS

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

The Therapeutic Implications of Plasticity of the Cancer Stem Cell Phenotype

(2010) Kevin Leder et al.   PLoS One

Cancer stem cells in solid tumors

(2010) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

ABCB8 Mediates Doxorubicin Resistance in Melanoma Cells by Protecting the Mitochondrial Genome

(2009) Aaron M. Elliott et al.   MOLECULAR CANCER RESEARCH

Specific IKKβ inhibitor IV blocks streptonigrin-induced NF-κB activity and potentiates its cytotoxic effect on cancer cells

(2009) Maria Gavriil et al.   MOLECULAR CARCINOGENESIS

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Conjugates of the fungal cytotoxin illudin M with improved tumour specificity

(2008) Rainer Schobert et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE