HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors

New regulation mechanisms of osteoclast differentiation

(2012) Tomoki Nakashima et al.   Annals of the New York Academy of Sciences

Membrane-bound receptor activator of NFκB ligand (RANKL) activity displayed by osteoblasts is differentially regulated by osteolytic factors

(2012) Preetinder P. Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HSP90 inhibition: two-pronged exploitation of cancer dependencies

(2011) Jon Travers et al.   DRUG DISCOVERY TODAY

Advances in the biology of bone metastasis: How the skeleton affects tumor behavior

(2010) Julie A. Sterling et al.   BONE

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

(2010) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity

(2010) T. J. Yun et al.   JOURNAL OF IMMUNOLOGY

Mitf Induction by RANKL Is Critical for Osteoclastogenesis

(2010) Ssu-Yi Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Examining the Metastatic Niche: Targeting the Microenvironment

(2010) Theresa Guise   SEMINARS IN ONCOLOGY

Control of RANKL gene expression

(2009) Charles A. O'Brien   BONE

Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation

(2009) Insun Song et al.   FEBS LETTERS

Myocyte Enhancer Factor 2 and Microphthalmia-associated Transcription Factor Cooperate with NFATc1 to Transactivate the V-ATPase d2 Promoter during RANKL-induced Osteoclastogenesis

(2009) HaoTian Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

The Mechanism of Osteoclast Differentiation Induced by IL-1

(2009) J. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Coupling bone degradation to formation

(2009) Jameel Iqbal et al.   NATURE MEDICINE

Discovery and development of heat shock protein 90 inhibitors

(2008) Tony Taldone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Targeting Hsp90: small-molecule inhibitors and their clinical development

(2008) Tony Taldone et al.   CURRENT OPINION IN PHARMACOLOGY

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

(2008) A. Yano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor-β enables NFATc1 expression during osteoclastogenesis

(2007) S.W. Fox et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS