Calpastatin prevents Angiotensin II-mediated podocyte injury through maintenance of autophagy

Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production

(2020) Zhifeng Liu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy

(2019) Sang-Bing Ong et al.   Stem Cell Reports

Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond

(2019) Jonasz Jeremiasz Weber et al.   Biomed Research International

The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression

(2019) Hélène Lazareth et al.   Nature Communications

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

(2019) Louise K. Farmer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer

(2019) Ze-Xian Liu et al.   Frontiers in Genetics

The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury

(2018) Kim A.T. Verheijden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Specific calpain inhibition protects kidney against inflammaging

(2017) Guillaume Hanouna et al.   Scientific Reports

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Calpain-10 Activity Underlies Angiotensin II-Induced Aldosterone Production in an Adrenal Glomerulosa Cell Model

(2015) Mutsa Seremwe et al.   ENDOCRINOLOGY

Calpains Released by T Lymphocytes Cleave TLR2 To Control IL-17 Expression

(2015) Joëlle Perez et al.   JOURNAL OF IMMUNOLOGY

Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor   Essential for Resistance to Crescentic GN

(2015) C. Henique et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Differential regulation of the calpain–calpastatin complex by the L-domain of calpastatin

(2014) Roberta De Tullio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Direct Action of Endothelin-1 on Podocytes Promotes Diabetic Glomerulosclerosis

(2014) O. Lenoir et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Risk Factors for ESRD in Individuals With Preserved Estimated GFR With and Without Albuminuria: Results From the Kidney Early Evaluation Program (KEEP)

(2013) Tara I. Chang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Podocyturia Predates Proteinuria and Clinical Features of Preeclampsia

(2013) Iasmina M. Craici et al.   HYPERTENSION

The Calpain/Calpastatin System Has Opposing Roles in Growth and Metastatic Dissemination of Melanoma

(2013) Quentin Raimbourg et al.   PLoS One

Calpastatin Controls Polymicrobial Sepsis by Limiting Procoagulant Microparticle Release

(2012) Lara Zafrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Autophagy: a novel therapeutic target for kidney diseases

(2012) Shinji Kume et al.   Clinical and Experimental Nephrology

The Renin-Angiotensin-Aldosterone System in Podocytes

(2012) Dirk Oliver Wennmann et al.   SEMINARS IN NEPHROLOGY

The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy

(2011) Matem Tunçdemir et al.   ACTA HISTOCHEMICA

Angiotensin II Contributes to Podocyte Injury by Increasing TRPC6 Expression via an NFAT-Mediated Positive Feedback Signaling Pathway

(2011) Tom Nijenhuis et al.   AMERICAN JOURNAL OF PATHOLOGY

Calpains Contribute to Vascular Repair in Rapidly Progressive Form of Glomerulonephritis: Potential Role of Their Externalization

(2011) Béatrice Letavernier et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Implications of autophagy for glomerular aging and disease

(2011) Thomas Weide et al.   CELL AND TISSUE RESEARCH

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

(2011) Guillaume Bollée et al.   NATURE MEDICINE

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

ANG II promotes autophagy in podocytes

(2010) Anju Yadav et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Critical role of the calpain/calpastatin balance in acute allograft rejection

(2010) Emmanuel Letavernier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte Loss in Human Hypertensive Nephrosclerosis

(2009) G. Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

Intrarenal Expression of miRNAs in Patients With Hypertensive Nephrosclerosis

(2009) G. Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

Who Should Be Targeted for CKD Screening? Impact of Diabetes, Hypertension, and Cardiovascular Disease

(2009) Allan J. Collins et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Angiotensin II Infusion Induces Nephrin Expression Changes and Podocyte Apoptosis

(2008) Junya Jia et al.   AMERICAN JOURNAL OF NEPHROLOGY

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Targeting the Calpain/Calpastatin System as a New Strategy to Prevent Cardiovascular Remodeling in Angiotensin II–Induced Hypertension

(2008) Emmanuel Letavernier et al.   CIRCULATION RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE