Impacts of Humanized Mouse Models on the Investigation of HIV-1 Infection: Illuminating the Roles of Viral Accessory Proteins in Vivo

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

(2015) Daniel Sauter et al.   Cell Reports

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Effect of Vaginal Immunization with HIVgp140 and HSP70 on HIV-1 Replication and Innate and T Cell Adaptive Immunity in Women

(2014) D. J. M. Lewis et al.   JOURNAL OF VIROLOGY

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

(2014) Alejandro B Balazs et al.   NATURE MEDICINE

Preservation of Tetherin and CD4 Counter-Activities in Circulating Vpu Alleles despite Extensive Sequence Variation within HIV-1 Infected Individuals

(2014) Suzanne Pickering et al.   PLoS Pathogens

APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

(2014) Kei Sato et al.   PLoS Pathogens

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

(2013) Belete A. Desimmie et al.   JOURNAL OF MOLECULAR BIOLOGY

In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

(2013) Richard L Watkins et al.   Retrovirology

Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice

(2013) Vibhuti P Dave et al.   Retrovirology

HIV Restriction Factors and Mechanisms of Evasion

(2013) M. H. Malim et al.   Cold Spring Harbor Perspectives in Medicine

Interleukin-7 Facilitates HIV-1 Transmission to Cervico-Vaginal Tissue ex vivo

(2013) Andrea Introini et al.   PLoS Pathogens

HIV Restriction by APOBEC3 in Humanized Mice

(2013) John F. Krisko et al.   PLoS Pathogens

HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

(2013) Kei Sato et al.   PLoS Pathogens

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Innate Sensing of HIV-1 Assembly by Tetherin Induces NFκB-Dependent Proinflammatory Responses

(2012) Rui Pedro Galão et al.   Cell Host & Microbe

Current advances in humanized mouse models

(2012) Ryoji Ito et al.   Cellular & Molecular Immunology

Vpu Augments the Initial Burst Phase of HIV-1 Propagation and Downregulates BST2 and CD4 in Humanized Mice

(2012) K. Sato et al.   JOURNAL OF VIROLOGY

Animal models for HIV/AIDS research

(2012) Theodora Hatziioannou et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 Expressing the Envelopes of Transmitted/Founder or Control/Reference Viruses Have Similar Infection Patterns of CD4 T-Cells in Human Cervical Tissue Ex Vivo

(2012) Melanie Merbah et al.   PLoS One

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

(2012) Lillian S Kuo et al.   Retrovirology

One Protein to Rule them All: Modulation of Cell Surface Receptors and Molecules by HIV Nef

(2011) Alessia Landi et al.   CURRENT HIV RESEARCH

The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models

(2011) Kei Sato et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

(2011) John L. Foster et al.   Journal of Neuroimmune Pharmacology

Upregulation of BST-2/Tetherin by HIV Infection In Vivo

(2011) S. Homann et al.   JOURNAL OF VIROLOGY

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

(2011) Kevin C Olivieri et al.   Retrovirology

HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef

(2011) Daniel Sauter et al.   Retrovirology

Lack of adaptation to human tetherin in HIV-1 Group O and P

(2011) Su Jung Yang et al.   Retrovirology

Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

(2011) Tim Willinger et al.   TRENDS IN IMMUNOLOGY

Structural Features of Antiviral APOBEC3 Proteins are Linked to Their Functional Activities

(2011) Shingo Kitamura et al.   Frontiers in Microbiology

Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments

(2010) M. Moll et al.   BLOOD

Degranulation of Natural Killer Cells Following Interaction with HIV-1-Infected Cells Is Hindered by Downmodulation of NTB-A by Vpu

(2010) Ankur H. Shah et al.   Cell Host & Microbe

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

(2010) John S. Albin et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections

(2010) Jason M. Brenchley et al.   IMMUNITY

Differential Anti-APOBEC3G Activity of HIV-1 Vif Proteins Derived from Different Subtypes

(2010) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice

(2010) K. Sato et al.   JOURNAL OF VIROLOGY

Identification of Specific Determinants of Human APOBEC3F, APOBEC3C, and APOBEC3DE and African Green Monkey APOBEC3F That Interact with HIV-1 Vif

(2010) J. L. Smith et al.   JOURNAL OF VIROLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication

(2010) T. Izumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BST-2/tetherin: a new component of the innate immune response to enveloped viruses

(2010) David T. Evans et al.   TRENDS IN MICROBIOLOGY

Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain

(2010) Martine Braibant et al.   VIROLOGY

The Great Escape: Viral Strategies to Counter BST-2/Tetherin

(2010) Janet L. Douglas et al.   PLoS Pathogens

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing

(2009) J. Richard et al.   BLOOD

HIV-1 Antagonism of CD317 Is Species Specific and Involves Vpu-Mediated Proteasomal Degradation of the Restriction Factor

(2009) Christine Goffinet et al.   Cell Host & Microbe

Tetherin-Driven Adaptation of Vpu and Nef Function and the Evolution of Pandemic and Nonpandemic HIV-1 Strains

(2009) Daniel Sauter et al.   Cell Host & Microbe

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Selective infection of CD4+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-1-infected humanized NOD/SCID/IL-2Rγnull mice

(2009) Chuanyi Nie et al.   VIROLOGY

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

(2009) Jeffrey Ward et al.   PLoS Pathogens

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens

Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model

(2008) N. Tonomura et al.   BLOOD

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

HIV-1 Vpr: Mechanisms of G2 arrest and apoptosis

(2008) Joshua L. Andersen et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE