In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis

HIV-1 Nef Mediates Pak Phosphorylation of Mek1 Serine298 and Elicits an Active Phospho-state of Pak2

(2013) Arlette Kouwenhoven et al.   CURRENT HIV RESEARCH

Dynamic range of Nef functions in chronic HIV-1 infection

(2013) Philip Mwimanzi et al.   VIROLOGY

HIV Restriction by APOBEC3 in Humanized Mice

(2013) John F. Krisko et al.   PLoS Pathogens

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

(2012) Libin Abraham et al.   Cell Communication and Signaling

Alpha Interferon and HIV Infection Cause Activation of Human T Cells in NSG-BLT Mice

(2012) B. R. Long et al.   JOURNAL OF VIROLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

(2012) Lillian S Kuo et al.   Retrovirology

Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

(2012) Paul W. Denton et al.   TRENDS IN MICROBIOLOGY

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

(2011) John L. Foster et al.   Journal of Neuroimmune Pharmacology

Down-Modulation of CD8   Is a Fundamental Activity of Primate Lentiviral Nef Proteins

(2011) A. Heigele et al.   JOURNAL OF VIROLOGY

Secretion Modification Region-Derived Peptide Disrupts HIV-1 Nef's Interaction with Mortalin and Blocks Virus and Nef Exosome Release

(2011) M. N. Shelton et al.   JOURNAL OF VIROLOGY

One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Generation of HIV Latency in Humanized BLT Mice

(2011) P. W. Denton et al.   JOURNAL OF VIROLOGY

Nef-mediated enhancement of cellular activation and human immunodeficiency virus type 1 replication in primary T cells is dependent on association with p21-activated kinase 2

(2011) Kevin C Olivieri et al.   Retrovirology

HIV-Nef and AIDS pathogenesis: are we barking up the wrong tree?

(2011) Andreas S. Baur   TRENDS IN MICROBIOLOGY

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rγnull mice

(2010) Deepika Rajesh et al.   HUMAN IMMUNOLOGY

Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins

(2010) Nadine Laguette et al.   MOLECULAR ASPECTS OF MEDICINE

Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT Mice

(2010) Paul W. Denton et al.   PLoS One

Autophagy and HIV

(2010) Christina Dinkins et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Role of Nef in primate lentiviral immunopathogenesis

(2008) F. Kirchhoff et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Immunodeficiency Virus Type 1 Nef Induces Programmed Death 1 Expression through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism

(2008) K. Muthumani et al.   JOURNAL OF VIROLOGY

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE

Inefficient Nef-Mediated Downmodulation of CD3 and MHC-I Correlates with Loss of CD4+ T Cells in Natural SIV Infection

(2008) Michael Schindler et al.   PLoS Pathogens

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

(2007) Anke Specht et al.   VIROLOGY