Genetic Diversity and Selective Pressure in Hepatitis C Virus Genotypes 1–6: Significance for Direct-Acting Antiviral Treatment and Drug Resistance

Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region

(2015) Christoph Sarrazin et al.   ANTIVIRAL RESEARCH

All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study

(2015) David R. Nelson et al.   HEPATOLOGY

Hepatitis C virus drug resistance-associated substitutions: State of the art summary

(2015) Erik Lontok et al.   HEPATOLOGY

HCV NS5A resistance-associated variants in a group of real-world Japanese patients chronically infected with HCV genotype 1b

(2015) Yosuke Hirotsu et al.   Hepatology International

Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies

(2015) Oliver Lenz et al.   JOURNAL OF HEPATOLOGY

EASL Recommendations on Treatment of Hepatitis C 2015

(2015)   JOURNAL OF HEPATOLOGY

An integrated map of HIV genome-wide variation from a population perspective

(2015) Guangdi Li et al.   Retrovirology

Update on hepatitis C virus resistance to direct-acting antiviral agents

(2014) Eva Poveda et al.   ANTIVIRAL RESEARCH

Molecular modeling and residue interaction network studies on the mechanism of binding and resistance of the HCV NS5B polymerase mutants to VX-222 and ANA598

(2014) Weiwei Xue et al.   ANTIVIRAL RESEARCH

RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies

(2014) Alexandros Stamatakis   BIOINFORMATICS

Detection of a Sexually Transmitted Hepatitis C Virus Protease Inhibitor-Resistance Variant in a Human Immunodeficiency Virus–Infected Homosexual Man

(2014) Sandra Franco et al.   GASTROENTEROLOGY

Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir

(2014) Eric F. Donaldson et al.   HEPATOLOGY

Global distribution and prevalence of hepatitis C virus genotypes

(2014) Jane P. Messina et al.   HEPATOLOGY

Key Binding and Susceptibility of NS3/4A Serine Protease Inhibitors against Hepatitis C Virus

(2014) Arthitaya Meeprasert et al.   Journal of Chemical Information and Modeling

Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition

(2014) James H. Nettles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial

(2014) Ira M Jacobson et al.   LANCET

Benefits of hepatitis C virus treatment: A balance of preventing onward transmission and re-infection

(2014) A.S. de Vos et al.   MATHEMATICAL BIOSCIENCES

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

(2014) Nezam Afdhal et al.   NEW ENGLAND JOURNAL OF MEDICINE

COMET: adaptive context-based modeling for ultrafast HIV-1 subtype identification

(2014) Daniel Struck et al.   NUCLEIC ACIDS RESEARCH

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

(2014) Sebastian M. Lambert et al.   PROTEIN SCIENCE

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

(2014) L. Swadling et al.   Science Translational Medicine

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

(2014) David B. Ascher et al.   Scientific Reports

Challenges to the development of vaccines to hepatitis C virus that elicit neutralizing antibodies

(2014) Heidi E. Drummer   Frontiers in Microbiology

Protective Immunity Against Hepatitis C: Many Shades of Gray

(2014) Mohamed S. Abdel-Hakeem et al.   Frontiers in Immunology

Hepatitis C virus reinfection incidence and treatment outcome among HIV-positive MSM

(2013) Thomas C.S. Martin et al.   AIDS

Evolution of Treatment-Emergent Resistant Variants in Telaprevir Phase 3 Clinical Trials

(2013) James C. Sullivan et al.   CLINICAL INFECTIOUS DISEASES

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource

(2013) Donald B. Smith et al.   HEPATOLOGY

Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies

(2013) Homer Pantua et al.   JOURNAL OF MOLECULAR BIOLOGY

Treatment of hepatitis C virus genotype 3-infection

(2013) Stanislas Pol et al.   LIVER INTERNATIONAL

New therapeutic strategies in HCV: second-generation protease inhibitors

(2013) Virginia C. Clark et al.   LIVER INTERNATIONAL

Building Phylogenetic Trees from Molecular Data with MEGA

(2013) B. G. Hall   MOLECULAR BIOLOGY AND EVOLUTION

Current progress in development of hepatitis C virus vaccines

(2013) T Jake Liang   NATURE MEDICINE

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection

(2013) Eric Lawitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sequencing of the Hepatitis C Virus: A Systematic Review

(2013) Brendan Jacka et al.   PLoS One

Prevalence of Hepatitis C Virus Subgenotypes 1a and 1b in Japanese Patients: Ultra-Deep Sequencing Analysis of HCV NS5B Genotype-Specific Region

(2013) Shuang Wu et al.   PLoS One

Molecular Modeling Comparison of the Performance of NS5b Polymerase Inhibitor (PSI-7977) on Prevalent HCV Genotypes

(2013) Abdo A. Elfiky et al.   PROTEIN JOURNAL

Functional conservation of HIV-1 Gag: implications for rational drug design

(2013) Guangdi Li et al.   Retrovirology

Characterizations of HCV NS5A replication complex inhibitors

(2013) Donald R. O'Boyle II et al.   VIROLOGY

New insights regarding HCV-NS5A structure/function and indication of genotypic differences

(2012) Lilian HT Yamasaki et al.   Virology Journal

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

(2012) Keith P. Romano et al.   PLoS Pathogens

The mode and tempo of hepatitis C virus evolution within and among hosts

(2011) Rebecca R Gray et al.   BMC EVOLUTIONARY BIOLOGY

Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1

(2011) Richard E. Nettles et al.   HEPATOLOGY

The natural history of early hepatitis C virus evolution; lessons from a global outbreak in human immunodeficiency virus-1-infected individuals

(2011) E. C. Thomson et al.   JOURNAL OF GENERAL VIROLOGY

A new standard of care for the treatment of chronic HCV infection

(2011) Wolf Peter Hofmann et al.   Nature Reviews Gastroenterology & Hepatology

Telaprevir for Retreatment of HCV Infection

(2011) Stefan Zeuzem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints

(2011) Joke Snoeck et al.   Retrovirology

An overview of HCV molecular biology, replication and immune responses

(2011) Usman A Ashfaq et al.   Virology Journal

Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel

(2011) Laurent Chatel-Chaix et al.   Viruses-Basel

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

(2010) Maxwell D. Cummings et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genotype 1 and global hepatitis C T-cell vaccines designed to optimize coverage of genetic diversity

(2010) K. Yusim et al.   JOURNAL OF GENERAL VIROLOGY

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

(2010) K. P. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation among HSP60 sequences in relation to structure, function, and evolution

(2010) Luciano Brocchieri et al.   PROTEIN SCIENCE

Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C

(2010) Severine Margeridon-Thermet et al.   Viruses-Basel

SeaView Version 4: A Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building

(2009) M. Gouy et al.   MOLECULAR BIOLOGY AND EVOLUTION

A standardized framework for accurate, high-throughput genotyping of recombinant and non-recombinant viral sequences

(2009) L. C. J. Alcantara et al.   NUCLEIC ACIDS RESEARCH

Natural Prevalence of Hepatitis C Virus Variants with Decreased Sensitivity to NS3·4A Protease Inhibitors in Treatment‐Naive Subjects

(2008) Doug J. Bartels et al.   JOURNAL OF INFECTIOUS DISEASES