Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

(2012) John R. Ussher et al.   CARDIOVASCULAR RESEARCH

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding

(2012) Liyan Zhang et al.   FEBS LETTERS

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

(2012) Paul M. Rindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle

(2012) Rita Rinnankoski-Tuikka et al.   Nutrition & Metabolism

A Quantitative Proteomic Profile of the Nrf2-Mediated Antioxidant Response of Macrophages to Oxidized LDL Determined by Multiplexed Selected Reaction Monitoring

(2012) Caroline S. Kinter et al.   PLoS One

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cardiac anaplerosis in health and disease: food for thought

(2011) C. Des Rosiers et al.   CARDIOVASCULAR RESEARCH

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

(2011) Kari T. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concentration-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes

(2011) Satoshi Iwakami et al.   PLoS One

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Monitoring phosphorylation of the pyruvate dehydrogenase complex

(2009) Matthew J. Rardin et al.   ANALYTICAL BIOCHEMISTRY

Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet

(2009) Byounghoon Hwang et al.   BIOCHEMICAL JOURNAL

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding

(2009) Jordan J. Wright et al.   CARDIOVASCULAR RESEARCH

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet-Induced Obese Mice Lacking Malonyl CoA Decarboxylase

(2009) J. R. Ussher et al.   DIABETES

Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2Emission during Long-chain Fatty Acid Oxidation

(2009) Erin L. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac Remodeling in Obesity

(2008) E. Dale Abel et al.   PHYSIOLOGICAL REVIEWS

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy

(2007) Guixiang Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY