Article
Hematology
Kathryn N. Phoenix, Zhichao Yue, Lixia Yue, Chunxia G. Cronin, Bruce T. Liang, Luke H. Hoeppner, Kevin P. Claffey
Summary: This study identifies PLC beta 2 as a key regulator of vascular permeability induced by VEGF, functioning through regulation of calcium flux and phosphatidylinositol 4,5-bisphosphate levels. Targeting PLC beta 2 could provide a novel approach to regulate vascular permeability in patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Nutrition & Dietetics
Eduardo Iglesias-Gutierrez, Angela Garcia-Gonzalez, Ana Montero-Bravo, Antonio Gonzalez-Medina, Judit Joglar, Cristina Tomas-Zapico, Benjamin Fernandez-Garcia, Manuel Fernandez-Sanjurjo, David de Gonzalo-Calvo, Angel Enrique Diaz-Martinez, Natalia Ubeda
Summary: This study found that plasma homocysteine levels increase significantly after a 10K race and a marathon, with oxidative status affected by the dose of exercise. However, the increase in homocysteine is not correlated with exercise-induced pro-oxidant status and oxidative stress mechanisms related to endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Gui-Lan Chen, Bo Zeng, Hongni Jiang, Nikoleta Daskoulidou, Rahul Saurabh, Rumbidzai J. Chitando, Shang-Zhong Xu
Summary: An elevated level of circulating homocysteine is considered a risk factor for cardiovascular disease, but lowering therapy has unsatisfying clinical benefits. Researchers investigated the roles of calcium influx through TRPC channels and the regulation by Hcy-copper complexes. Hcy increased calcium influx in vascular endothelial cells through the activation of TRPC4 and TRPC5, which were regulated by extracellular divalent copper and Hcy. Hcy-copper complexes significantly regulated endothelial cell functions.
Review
Immunology
Suowen Xu, Qing Rex Lyu, Iqra Ilyas, Xiao-Yu Tian, Jianping Weng
Summary: Atherosclerosis is a chronic disease characterized by lipid deposition, inflammation, and impaired inflammation resolution, leading to narrowing of blood vessels, hardening, and plaque formation. Recent evidence suggests that the vascular system can be viewed as a complex homeostatic system, similar to a mini-ecosystem, consisting of the vascular microenvironment and the interaction among different types of vascular cells. By studying the cellular components in the vascular wall and their impact on vascular homeostasis, structure, function, and atherosclerosis, we can gain insights into the pathogenesis and explore vascular-stabilizing strategies to prevent cardiovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Shuo Feng, Jia Wei Chen, Xin Yi Shu, Muladili Aihemaiti, Jin Wei Quan, Lin Lu, Rui Yan Zhang, Chen Die Yang, Xiao Qun Wang
Summary: Hemodynamic shear stress (SS) regulates vascular homeostasis and injury through the release of endothelial microparticles (EMP), affecting physiological function of endothelial cells, inflammatory response, vascular permeability, and the coagulation system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yinzhen Fan, Zhenli Cheng, Lejiao Mao, Ge Xu, Na Li, Mengling Zhang, Ping Weng, Lijun Zheng, Xiaomei Dong, Siyao Hu, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Jun Zhang, Zhen Zou
Summary: This study found that CuONPs exposure disrupted mitochondrial dynamics in vascular endothelial cells through oxidative stress-dependent manner, as evidenced by increased mitochondrial fission and accumulation of fragmented mitochondria. Inhibition of mitochondrial fission aggravated CuONPs-induced mtROS production and cell death. Furthermore, mitochondrial fission led to the activation of PINK1-mediated mitophagy, and inhibition of mitophagy repressed CuONPs-induced toxicity. TAX1BP1 was identified as the primary receptor linking ubiquitinated mitochondria with autophagosomes, and its knockdown aggravated CuONPs-induced cell death. Urolithin A, a mitophagy activator, promoted mtROS clearance and removal of damaged mitochondria induced by CuONPs exposure both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Ruiying Wang, Min Wang, Jingxue Ye, Guibo Sun, Xiaobo Sun
Summary: Atherosclerosis is a chronic disease with complex pathology that can lead to various cardiovascular and cerebrovascular diseases. Endothelial cell injury is considered the main trigger for its occurrence and development, affecting by glycolysis regulation. Genes associated with AS and endothelial cell glycolysis play a key role in regulating multiple signaling pathways associated with cell signal transduction, energy metabolism, immune function, and thrombosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Guang Chen, Jia Li, Huimin Han, Ruiying Du, Xu Wang
Summary: Copper is an essential micronutrient that plays important roles in various biological processes. However, excess copper can have detrimental effects on plant growth and development. This review summarizes the biological functions of copper, the toxicity of excess copper to plants, and the transport process and detoxification mechanisms of copper in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shengnan Liu, Yingyin Zhao, Hanming Yao, Lizhen Zhang, Cui Chen, Zhinan Zheng, Sanqing Jin
Summary: Vascular endothelial cells (VECs) injury is the first step in the pathogenesis of atherosclerosis (AS), and mitochondrial dysfunction plays a significant role in this injury. This study reveals that mitochondrial dynamics disorder is a prominent feature of VECs in AS models and is associated with mitochondrial dysfunction. Additionally, the knockdown of dynamin-related protein 1 (DRP1) alleviates the mitochondrial dynamics disorder and VECs injury in vitro and in vivo, while DRP1 overexpression aggravated this injury. Atorvastatin, a classical anti-atherosclerotic drug, inhibited the expression of DRP1 and alleviated the mitochondrial dynamics disorder and VECs injury.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Plant Sciences
Linfeng Dai, Li Zhu, Shiyu Ma, Jingya Liu, Minyi Zhang, Jieyi Li, Yong Luo, Xing Zhou, Qiuxiong Chen, Lei Wang, Yi Huang, Yang Chen
Summary: This study aimed to investigate the regulatory effect of berberine (BBR) on endothelial junction function in inflammatory vascular injury. The results showed that BBR restored the expression of junction proteins and inhibited the activation of NLRP3 inflammasomes in endothelial cells. Additionally, BBR exhibited a similar effect to eliminating extracellular calcium. These findings suggest that BBR has therapeutic potential in inflammatory vascular injury by targeting calcium signals and the NLRP3 inflammasome.
Article
Biochemistry & Molecular Biology
Michael Jan, Ramon Cueto, Xiaohua Jiang, Liu Lu, Jason Sardy, Xinyu Xiong, Justine E. Yu, Hung Pham, Mohsin Khan, Xuebing Qin, Yong Ji, Xiao-Feng Yang, Hong Wang
Summary: This study reveals the molecular and metabolic mechanisms underlying HHcy-induced endothelial injury, showing that HHcy affects metabolism, inflammatory responses, cell degradation, and cell cycle progression. These findings provide valuable insights for understanding and potentially targeting HHcy-related cardiovascular diseases.
Article
Chemistry, Applied
Li Fu, Qingmei Chen, Li Jia
Summary: A core-satellite nanocomposite was developed for the selective detection of Gram-negative bacteria with a linear response. The sensor exhibited good selectivity towards Gram-negative bacteria through a quenching mechanism and reduction reaction. This study validated the feasibility of the sensor through analysis of bacterial samples with recoveries ranging from 93.9% to 109%.
Article
Cell Biology
Xia Qin, Jun Zhang, Bin Wang, Ge Xu, Xi Yang, Zhen Zou, Chao Yu
Summary: Zinc oxide nanoparticles can induce ferroptosis in endothelial cells, characterized by increased intracellular iron levels, lipid peroxidation, and cell death. NCOA4-mediated ferritinophagy plays a crucial role in ZnONPs-induced ferroptosis.
Article
Cardiac & Cardiovascular Systems
Claire Conway, Farhad R. Nezami, Campbell Rogers, Adam Groothuis, James C. Squire, Elazer R. Edelman
Summary: This study investigated the effects of different stent designs on arterial injury through numerical simulations and ex vivo experiments. The research found that arterial endothelial denudation can be caused by high circumferential stress in the arterial tissue, with an increase in stent radial thickness leading to more denudation areas and larger areas exposed to low wall shear stress. High circumferential hoop stresses in the interstrut region were identified as the cause of acute arterial injury immediately following stent expansion, and denuded area profiles were found to be dependent on unit cell geometric features, which might explain drug-device interactions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Jianwen Liang, Xiaoyu Zhang, Wenhao Xia, Xinzhu Tong, Yanxia Qiu, Yumin Qiu, Jiang He, Bingbo Yu, Hui Huang, Jun Tao
Summary: Aerobic exercise can improve microvascular rarefaction in hypertensive patients, reduce blood pressure, and enhance endothelial progenitor cells' angiogenic capacity via the NOTCH 1/Akt/eNOS signaling pathway.
Article
Cell Biology
Philipp P. Prosseda, Na Luo, Biao Wang, Jorge A. Alvarado, Yang Hu, Yang Sun
JOURNAL OF CELL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Jiqin Zhang, Fei Song, Xiaojing Zhao, Hua Jiang, Xiuqi Wu, Biao Wang, Min Zhou, Mi Tian, Bizhi Shi, Huamao Wang, Yuanhui Jia, Hai Wang, Xiaorong Pan, Zonghai Li
Article
Toxicology
Xi Chen, Jianxiang Zhong, Daoyin Dong, Gentao Liu, Peixin Yang
TOXICOLOGICAL SCIENCES
(2017)
Article
Multidisciplinary Sciences
Fang Wang, Cheng Xu, E. Albert Reece, Xuezheng Li, Yanqing Wu, Christopher Harman, Jingwen Yu, Daoyin Dong, Cheng Wang, Penghua Yang, Jianxiang Zhong, Peixin Yang
NATURE COMMUNICATIONS
(2017)
Article
Obstetrics & Gynecology
Yang Zhao, Daoyin Dong, E. Albert Reece, Ashley R. Wang, Peixin Yang
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Article
Behavioral Sciences
Daoyin Dong, Horst Ronald Zielke, David Yeh, Peixin Yang
Article
Cell Biology
Wen Xu, Fei Song, Biao Wang, Kesang Li, Mi Tian, Min Yu, Xiaorong Pan, Bizhi Shi, Jianwen Liu, Jianren Gu, Zonghai Li, Hua Jiang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Cell & Tissue Engineering
Xi Chen, Wei-Bin Shen, Penghua Yang, Daoyin Dong, Winny Sun, Peixin Yang
STEM CELLS AND DEVELOPMENT
(2018)
Article
Cell Biology
Israel C. Nnah, Biao Wang, Chaitali Saqcena, Gregory F. Weber, Edward M. Bonder, Dustin Bagley, Rossella De Cegli, Gennaro Napolitano, Diego L. Medina, Andrea Ballabio, Radek Dobrowolski
Article
Multidisciplinary Sciences
Philipp P. Prosseda, Jorge A. Alvarado, Biao Wang, Tia J. Kowal, Ke Ning, W. Daniel Stamer, Yang Hu, Yang Sun
Article
Cell Biology
Xianming Zhang, Hua Jin, Xiaojia Huang, Birendra Chaurasiya, Daoyin Dong, Thomas P. Shanley, You-Yang Zhao
Summary: A newly developed nanoparticle-based delivery system has shown high efficiency in genome editing of vascular endothelial cells. This system can selectively decrease protein expression by 80%, achieving a phenotype similar to genetic knockout mice. Furthermore, it has the capability to edit multiple genes or perform both genome editing and transgene expression simultaneously, making it a powerful tool for gene therapy and cardiovascular research.
Meeting Abstract
Cardiac & Cardiovascular Systems
Jingbo Dai, Zhiyu Dai, Mengqi Zhu, Daoyin Dong, Youyang Zhao
Meeting Abstract
Obstetrics & Gynecology
Daoyin Dong, Peixin Yang
REPRODUCTIVE SCIENCES
(2019)
Meeting Abstract
Obstetrics & Gynecology
Daoyin Dong, E. Albert Reece, Wei-Bin Shen, Peixin Yang
REPRODUCTIVE SCIENCES
(2018)
Meeting Abstract
Obstetrics & Gynecology
Daoyin Dong, Wei-Bin Shen, Peixin Yang
REPRODUCTIVE SCIENCES
(2017)