Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41

Recorded scan times can limit the accuracy of sedimentation coefficients in analytical ultracentrifugation

(2013) Huaying Zhao et al.   ANALYTICAL BIOCHEMISTRY

HIV-1 envelope glycoprotein structure

(2013) Alan Merk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

HIV-1 Envelope Glycoprotein Trimers Display Open Quaternary Conformation When Bound to the gp41 Membrane-Proximal External-Region-Directed Broadly Neutralizing Antibody Z13e1

(2013) A. K. Harris et al.   JOURNAL OF VIROLOGY

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

(2013) Thomas Krey et al.   PLoS Pathogens

High-Precision Isothermal Titration Calorimetry with Automated Peak-Shape Analysis

(2012) Sandro Keller et al.   ANALYTICAL CHEMISTRY

A proteomics approach for the identification and cloning of monoclonal antibodies from serum

(2012) Wan Cheung Cheung et al.   NATURE BIOTECHNOLOGY

Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation

(2012) Erin E. H. Tran et al.   PLoS Pathogens

On the Distribution of Protein Refractive Index Increments

(2011) Huaying Zhao et al.   BIOPHYSICAL JOURNAL

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

(2011) J. C. Krause et al.   mBio

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

(2010) E. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

(2010) Elena Gustchina et al.   PLoS Pathogens

Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

(2010) Charles Sabin et al.   PLoS Pathogens

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

(2010) Laura M. Walker et al.   PLoS Pathogens

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

(2009) Elena Gustchina et al.   VIROLOGY

Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

(2009) Kristen M. Kahle et al.   PLoS Pathogens

The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System with a Novel Display Method for Efficient Selection of High-Affinity Antibodies

(2008) Christine Rothe et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

(2008) Josh D. Nelson et al.   VIROLOGY