Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

(2010) Donna L. Montgomery et al.   mAbs

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

(2010) Davide Corti et al.   PLoS One

Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

(2010) E. Bianchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

(2009) Elena Gustchina et al.   VIROLOGY

Asymmetric Deactivation of HIV-1 gp41 following Fusion Inhibitor Binding

(2009) Kristen M. Kahle et al.   PLoS Pathogens

Short Communication: In Vitro Synergy between Peptides or Neutralizing Antibodies Targeting the N- and C-Terminal Heptad Repeats of HIV Type 1 gp41

(2008) Renee Hrin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

ProtorP: a protein-protein interaction analysis server

(2008) C. Reynolds et al.   BIOINFORMATICS

The Human Combinatorial Antibody Library HuCAL GOLD Combines Diversification of All Six CDRs According to the Natural Immune System with a Novel Display Method for Efficient Selection of High-Affinity Antibodies

(2008) Christine Rothe et al.   JOURNAL OF MOLECULAR BIOLOGY

Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens

(2008) M.-Y. Zhang et al.   JOURNAL OF VIROLOGY

Sequestering of the Prehairpin Intermediate of gp41 by Peptide N36Mut(e,g) Potentiates the Human Immunodeficiency Virus Type 1 Neutralizing Activity of Monoclonal Antibodies Directed against the N-Terminal Helical Repeat of gp41

(2008) E. Gustchina et al.   JOURNAL OF VIROLOGY

Characterization of the steric defense of the HIV-1 gp41 N-trimer region

(2008) Debra M. Eckert et al.   PROTEIN SCIENCE

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

(2008) Josh D. Nelson et al.   VIROLOGY