Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

Published 2009 View Full Article

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Title
Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth
Authors
Keywords
-
Journal
VIROLOGY
Volume 393, Issue 1, Pages 112-119
Publisher
Elsevier BV
Online
2009-08-20
DOI
10.1016/j.virol.2009.07.019

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