Article
Immunology
Hongyan Xie, Shihao Xie, Mei Wang, Haixia Wei, He Huang, Anqi Xie, Jiajie Li, Chao Fang, Feihu Shi, Quan Yang, Yanwei Qi, Zhinan Yin, Xinhua Wang, Jun Huang
Summary: This study explores the role of gamma delta T cells in malaria infection and finds that these cells can promote both cellular and humoral immune responses. Using single-cell RNA sequencing, the study reveals the diversity of gamma delta T cells in the spleen. Additionally, the depletion of gamma delta T cells has a negative impact on the immune response in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nanang Rudianto Ariefta, Baldorj Pagmadulam, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: This study evaluated the growth-inhibitory effects of the antimalarial agent sparsomycin against drug-resistant malaria parasites. The results showed that sparsomycin had inhibitory effects on both sensitive and resistant strains of the parasites. This study suggests that sparsomycin has potential as an alternative treatment for malaria.
Article
Chemistry, Multidisciplinary
Fabiana Volpe-Zanutto, Leticia Tiburcio Ferreira, Andi Dian Permana, Melissa Kirkby, Alejandro J. Paredes, Lalitkumar K. Vora, Amanda P. Bonfanti, Ives Charlie-Silva, Catarina Raposo, Mariana C. Figueiredo, Ilza M. O. Sousa, Andi Brisibe, Fabio Trindade Maranhao Costa, Ryan F. Donnelly, Mary Ann Foglio
Summary: Malaria affects over 200 million people annually and artemether and lumefantrine are the primary treatment options. Dissolving microneedles were developed to deliver the drugs intradermally, with studies in animals demonstrating significant efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Parasitology
Feihu Shi, Shanni Tang, Dianhui Chen, Feng Mo, Jiajie Li, Chao Fang, Haixia Wei, Junmin Xing, Lin Liu, Yumei Gong, Zhengrong Tan, Ziqi Zhang, Xingfei Pan, Shan Zhao, Jun Huang
Summary: CD103 is an important marker of tissue-resident memory T cells, and its expression and immunological characteristics in the liver of mice infected with Plasmodium have not been thoroughly investigated. This study found that erythrocyte stage Plasmodium infection resulted in severe hepatic damage and decreased CD103 expression on hepatic immune cells. Furthermore, CD103(+)CD8(+) Tc cells displayed altered phenotype and cytokine production characteristics after infection.
PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Sonia Ghilas, Matthias H. Enders, Rose May, Lauren E. Holz, Daniel Fernandez-Ruiz, Anton Cozijnsen, Vanessa Mollard, Ian A. Cockburn, Geoffrey McFadden, William R. Heath, Lynette Beattie
Summary: Malaria remains a major cause of mortality worldwide, and an efficient vaccine is the best way to reduce the disease burden. By studying the induction of nonliving sporozoites on the development of specific liver T-RM cells, new possibilities for developing anti-malaria vaccines can be explored.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Infectious Diseases
Haixia Wei, Chenxi Jin, Anping Peng, Hongyan Xie, Shihao Xie, Yuanfa Feng, Anqi Xie, Jiajie Li, Chao Fang, Quan Yang, Huaina Qiu, Yanwei Qi, Zhinan Yin, Xinhua Wang, Jun Huang
Summary: This study found an increase in gamma delta T cells in the lungs of mice infected with Plasmodium, affecting the phenotype and function of other cells. Gamma delta T cells contribute significantly to the T cell immune response during Plasmodium infection.
Article
Microbiology
Wei Guan, Xiaonan Song, Shuguo Yang, Huiyin Zhu, Fang Li, Jian Li
Summary: This study investigated the gut microbiota composition of Py-infected BALB/c mice and found that Py infection could alter the gut microbiota composition. Furthermore, several bacterial taxa were found to be overrepresented at different time points after infection, providing insights into the progression and pathogenesis of malaria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Parasitology
Xueyan Hu, Jie Zhao, Junhui Zhao, Ence Yang, Mozhi Jia
Summary: The study found that during the blood stage of the parasite, patients with malaria exhibit activated immune responses, aberrant metabolic processes, and tissue remodeling changes in the liver, providing a systematic outline of liver responses during Plasmodium infection.
PARASITES & VECTORS
(2023)
Article
Integrative & Complementary Medicine
Ahmed M. Abdou, Abdel-latif S. Seddek, Noha Abdelmageed, Mohamed O. Badry, Yoshifumi Nishikawa
Summary: This study evaluated the antimalarial efficacy of several Egyptian plant extracts and identified four promising candidates for the treatment of malaria.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Immunology
Paul W. Rothlauf, Zeyang Li, Novalia Pishesha, Yushu Joy Xie, Andrew W. Woodham, Djenet Bousbaine, Stephen C. Kolifrath, Vincent L. Verschoor, Hidde L. Ploegh
Summary: Immuno-positron emission tomography (immuno-PET) is a noninvasive imaging method that allows for tracking immune cells in living animals. In a study using mouse models, CD8(+) T cells labeled with a Zr-89 nanobody showed specific migration patterns during an influenza A virus infection, suggesting a potential role in immune response modulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Summary: The study shows that effector memory CD8 T cells rapidly infiltrate the liver after malarial infection, mediating pathogen clearance through upregulation of inflammatory genes. This highlights the crucial role of Tem in protecting against malaria infection.
Article
Immunology
Mitchell N. Lefebvre, Lisa L. Drewry, Lecia L. Pewe, Lisa S. Hancox, Arturo Reyes-Sandoval, John T. Harty
Summary: A single, suboptimal weight-normalized RAS dose followed by subunit vaccination can increase the numbers of liver-stage-specific memory CD8 T cells. RAS+subunit prime-boost regimens are more effective than a single RAS vaccination. These findings have implications for human vaccine development and may reduce the logistical challenges of multiple RAS-only immunizations.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Anne Gunther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: This study demonstrates the involvement of acid ceramidase and ceramide in controlling P. yoelii infection, with a mechanism involving regulation of red blood cell development.
Article
Plant Sciences
Johnson Adejoh, Bassey A. Inyang, Maxwell O. Egua, Kenneth C. Nwachukwu, Lukman A. Alli, Michael P. Okoh
Summary: The study evaluated the anti-plasmodial activity of the ethanol extract of the strain against Plasmodium berghei-infected mice, demonstrating its potential as an anti-malarial agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Zengzi Zhou, Qi Tian, Luying Wang, Xin Sun, Nu Zhang, Min Xue, Dabao Xu, Guangming Zhong
Summary: This study validated the critical role of CD8(+) T cells in the induction of hydrosalpinx caused by Chlamydia trachomatis. CD8(+) T cells from wild type C57BL/6J mice were able to promote hydrosalpinx in OT1 mice through transfer. However, this promotion needed to be initiated within 2 weeks after infection, and once initiated, CD8(+) T cells could continue to promote hydrosalpinx for more than 3 weeks.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
Natalija Van Braeckel-Budimir, Stephanie Gras, Kristin Ladell, Tracy M. Josephs, Lecia Pewe, Stina L. Urban, Kelly L. Miners, Carine Farenc, David A. Price, Jamie Rossjohn, John T. Harty
Review
Cell Biology
Natalija Van Braeckel-Budimir, John T. Harty
IMMUNOLOGY AND CELL BIOLOGY
(2017)
Article
Medicine, Research & Experimental
Catherine Matte-Martone, Jinling Liu, Meng Zhou, Maria Chikina, Douglas R. Green, John T. Harty, Warren D. Shlomchik
JOURNAL OF CLINICAL INVESTIGATION
(2017)
Article
Immunology
Jodi A. Gullicksrud, Fengyin Li, Shaojun Xing, Zhouhao Zeng, Weiqun Peng, Vladimir P. Badovinac, John T. Harty, Hai-Hui Xue
JOURNAL OF IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Samarchith P. Kurup, Nyamekye Obeng-Adjei, Scott M. Anthony, Boubacar Traore, Ogobara K. Doumbo, Noah S. Butler, Peter D. Crompton, John T. Harty
Article
Microbiology
Deborah M. B. Post, Bram Slutter, Birgit Schilling, Aroon T. Chande, Jed A. Rasmussen, Bradley D. Jones, Alexandria K. D'Souza, Lorri M. Reinders, John T. Harty, Bradford W. Gibson, Michael A. Apicella
Article
Multidisciplinary Sciences
Farah R. Itani, Sushmita Sinha, Ashley A. Brate, Lecia L. Pewe, Katherine N. Gibson-Corley, John T. Harty, Nitin J. Karandikar
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Derek B. Danahy, Scott M. Anthony, Isaac J. Jensen, Stacey M. Hartwig, Qiang Shan, Hai-Hui Xue, John T. Harty, Thomas S. Griffith, Vladimir P. Badovinac
Article
Immunology
Natalija Van Braeckel-Budimir, Matthew D. Martin, Stacey M. Hartwig, Kevin L. Legge, Vladimir P. Badovinac, John T. Harty
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Matthew D. Martin, Derek B. Danahy, Stacey M. Hartwig, John T. Harty, Vladimir P. Badovinac
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Microbiology
Megan E. Schmidt, Cory J. Knudson, Stacey M. Hartwig, Lecia L. Pewe, David K. Meyerholz, Ryan A. Langlois, John T. Harty, Steven M. Varga
Article
Multidisciplinary Sciences
Aldo Vacaflores, Nicole M. Chapman, John T. Harty, Martin J. Richer, Jon C. D. Houtman
Article
Microbiology
Carson Bowers, Lisa Hancox, Kristen Peissig, Justine C. C. Shiau, Amelie Vantaux, Benoit Witkowski, Sivchheng Phal, Steven P. P. Maher, John T. T. Harty, Dennis E. E. Kyle, Samarchith P. P. Kurup
Summary: This study presents a method for cryopreservation of malaria sporozoites, which successfully preserves their structural integrity, viability, and infectiousness, as well as transgenic properties. The research offers a reliable protocol for the long-term storage and recovery of human and murine malaria sporozoites and lays the groundwork for the widespread use of live sporozoites for research and clinical applications.
Article
Immunology
Qiang Shan, Zhouhao Zeng, Shaojun Xing, Fengyin Li, Stacey M. Hartwig, Jodi A. Gullicksrud, Samarchith P. Kurup, Natalija Van Braeckel-Budimir, Yao Su, Matthew D. Martin, Steven M. Varga, Ichiro Taniuchi, John T. Harty, Weiqun Peng, Vladimir P. Badovinac, Hai-Hui Xue
Article
Immunology
Matthew A. Huggins, Holly L. Johnson, Fang Jin, Aurelie N. Songo, Lisa M. Hanson, Stephanie J. LaFrance, Noah S. Butler, John T. Harty, Aaron J. Johnson
INFECTION AND IMMUNITY
(2017)