Assumptions and Properties of Limiting Pathway Models for Analysis of Epistasis in Complex Traits

What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn

(2013) Kenneth S Kendler   MOLECULAR PSYCHIATRY

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

(2013) Kyriaki Michailidou et al.   NATURE GENETICS

An Evolutionary Perspective on Epistasis and the Missing Heritability

(2013) Gibran Hemani et al.   PLoS Genetics

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

On the Pleiotropic Structure of the Genotype-Phenotype Map and the Evolvability of Complex Organisms

(2012) W. G. Hill et al.   GENETICS

Understanding and predicting complex traits: knowledge from cattle

(2012) K. E. Kemper et al.   HUMAN MOLECULAR GENETICS

Comparison of heritabilities of dairy traits in Australian Holstein-Friesian cattle from genomic and pedigree data and implications for genomic evaluations

(2012) M. Haile-Mariam et al.   JOURNAL OF ANIMAL BREEDING AND GENETICS

Metabolism in the age of 'omes'

(2012) R. K. Suarez et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Drosophila melanogaster Genetic Reference Panel

(2012) Trudy F. C. Mackay et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

The continuing value of twin studies in the omics era

(2012) Jenny van Dongen et al.   NATURE REVIEWS GENETICS

Epistasis dominates the genetic architecture of Drosophila quantitative traits

(2012) W. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Underestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes

(2011) Sven Stringer et al.   PLoS One

The Danish Adoption Register

(2011) Liselotte Petersen et al.   SCANDINAVIAN JOURNAL OF PUBLIC HEALTH

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GWAS: heritability missing in action?

(2010) Angus J Clarke et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Systems genetics: The added value of gene expression

(2010) Peter M. Visscher et al.   HFSP Journal

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Mutations and quantitative genetic variation: lessons from Drosophila

(2010) T. F. C. Mackay   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies

(2010) A. Eyre-Walker   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintaining evolvability

(2009) James F. Crow   JOURNAL OF GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genetic Dominance Influences Blood Biomarker Levels in a Sample of 12,000 Swedish Elderly Twins

(2009) Iffat Rahman et al.   Twin Research and Human Genetics

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics