The continuing value of twin studies in the omics era

Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells

(2012) Lars A. Forsberg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Autism Spectrum Disorders and Autisticlike Traits

(2012) Sebastian Lundström   ARCHIVES OF GENERAL PSYCHIATRY

Gene Expression Differences in Skin Fibroblasts in Identical Twins Discordant for Type 1 Diabetes

(2012) M. L. Caramori et al.   DIABETES

Monozygotic twins discordant for constitutiveBRCA1promoter methylation, childhood cancer and secondary cancer

(2012) Danuta Galetzka et al.   Epigenetics

Genome-wide association study identifies multiple loci influencing human serum metabolite levels

(2012) Johannes Kettunen et al.   NATURE GENETICS

De novo mutations in human genetic disease

(2012) Joris A. Veltman et al.   NATURE REVIEWS GENETICS

Increased Expression and Altered Methylation of HERVWE1 in the Human Placentas of Smaller Fetuses from Monozygotic, Dichorionic, Discordant Twins

(2012) Yu Gao et al.   PLoS One

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

(2012) Kristina Gervin et al.   PLoS Genetics

HIV-1 infected monozygotic twins: a tale of two outcomes

(2011) Loubna Tazi et al.   BMC EVOLUTIONARY BIOLOGY

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

(2011) Lavinia Gordon et al.   Epigenetics

Copy number detection in discordant monozygotic twins of Congenital Diaphragmatic Hernia (CDH) and Esophageal Atresia (EA) cohorts

(2011) Danielle Veenma et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Twin Study Indicates Loss of Interaction Between Microbiota and Mucosa of Patients With Ulcerative Colitis

(2011) Patricia Lepage et al.   GASTROENTEROLOGY

Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent

(2011) J. E. Powell et al.   GENOME RESEARCH

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

(2011) Emma L. Dempster et al.   HUMAN MOLECULAR GENETICS

Genetic Influences on Pulmonary Function: A Large Sample Twin Study

(2011) Truls S. Ingebrigtsen et al.   LUNG

Human metabolic profiles are stably controlled by genetic and environmental variation

(2011) G. Nicholson et al.   Molecular Systems Biology

Family-based designs for genome-wide association studies

(2011) Jurg Ott et al.   NATURE REVIEWS GENETICS

Genome structural variation discovery and genotyping

(2011) Can Alkan et al.   NATURE REVIEWS GENETICS

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Heritability of Parkinson disease in Swedish twins: a longitudinal study

(2011) Karin Wirdefeldt et al.   NEUROBIOLOGY OF AGING

Impact of the Genome on the Epigenome Is Manifested in DNA Methylation Patterns of Imprinted Regions in Monozygotic and Dizygotic Twins

(2011) Marcel W. Coolen et al.   PLoS One

Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model

(2011) Bernet S Kato et al.   Proteome Science

A twin approach to unraveling epigenetics

(2011) Jordana T. Bell et al.   TRENDS IN GENETICS

Blood Ties: Chimerism Can Mask Twin Discordance in High-Throughput Sequencing

(2011) Yaniv Erlich   Twin Research and Human Genetics

Association of Lipidome Remodeling in the Adipocyte Membrane with Acquired Obesity in Humans

(2011) Kirsi H. Pietiläinen et al.   PLOS BIOLOGY

An Assessment of the Individual and Collective Effects of Variants on Height Using Twins and a Developmentally Informative Study Design

(2011) Scott I. Vrieze et al.   PLoS Genetics

Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation

(2011) Jason Gertz et al.   PLoS Genetics

The Architecture of Gene Regulatory Variation across Multiple Human Tissues: The MuTHER Study

(2011) Alexandra C. Nica et al.   PLoS Genetics

A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection

(2011) George Nicholson et al.   PLoS Genetics

Nature and nurture in infant appetite: analysis of the Gemini twin birth cohort

(2010) Clare H Llewellyn et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Estimates of asthma heritability in a large twin sample

(2010) S. F. Thomsen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Variability gene effect on cholesterol at the Kidd blood group locus

(2010) Kåre Berg   CLINICAL GENETICS

Monocyte Gene-Expression Profiles Associated With Childhood-Onset Type 1 Diabetes and Disease Risk: A Study of Identical Twins

(2010) H. Beyan et al.   DIABETES

A longitudinal study of epigenetic variation in twins

(2010) Chloe Chung Yi Wong et al.   Epigenetics

Cervix smear abnormalities: linking pathology data in female twins, their mothers and sisters

(2010) Jacqueline M Vink et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

(2010) AnhThu Nguyen et al.   FASEB JOURNAL

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

(2010) Ben P. Willing et al.   GASTROENTEROLOGY

The Shared Genetics of Migraine and Anxious Depression

(2010) Lannie Ligthart et al.   HEADACHE

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

(2010) Miina Ollikainen et al.   HUMAN MOLECULAR GENETICS

Genetics in twins with Crohnʼs disease: Less pronounced than previously believed?

(2010) Jonas Halfvarson   INFLAMMATORY BOWEL DISEASES

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

(2010) Sergio E. Baranzini et al.   NATURE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Timing of De Novo Mutagenesis — A Twin Study of Sodium-Channel Mutations

(2010) Lata Vadlamudi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Unique MicroRNA Signature Associated with Lupus Nephritis

(2010) Jeannie L. Te et al.   PLoS One

Monozygotic Twins With Neurofibromatosis Type 1 (NF1) Display Differences in Methylation of NF1 Gene Promoter Elements, 5' Untranslated region, Exon and Intron 1

(2010) Anja Harder et al.   Twin Research and Human Genetics

Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines

(2010) Tewarit Sarachana et al.   Genome Medicine

Influence of Genes and Environment on Brain Volumes in Twin Pairs Concordant and Discordant for Bipolar Disorder

(2009) Astrid C. van der Schot et al.   ARCHIVES OF GENERAL PSYCHIATRY

Characteristics and Concordance of Autism Spectrum Disorders Among 277 Twin Pairs

(2009) Rebecca E. Rosenberg et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

The Developmental Etiology of High IQ

(2009) Angela M. Brant et al.   BEHAVIOR GENETICS

DNA hypomethylation, transient neonatal diabetes, and prune belly sequence in one of two identical twins

(2009) Lene Bjerke Laborie et al.   EUROPEAN JOURNAL OF PEDIATRICS

Genetic influences on ‘environmental’ factors

(2009) A. A. E. Vinkhuyzen et al.   GENES BRAIN AND BEHAVIOR

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

(2009) B. M. Javierre et al.   GENOME RESEARCH

Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs

(2009) Paula H. A. Ronkainen et al.   JOURNAL OF APPLIED PHYSIOLOGY

The heritability of general cognitive ability increases linearly from childhood to young adulthood

(2009) C M A Haworth et al.   MOLECULAR PSYCHIATRY

Twin studies and the heritability of MS: a conclusion

(2009) CH Hawkes et al.   Multiple Sclerosis Journal

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Genetic and Environmental Contributions to Phenotypic Components of Metabolic Syndrome: A Population-based Twin Study

(2009) Shanchun Zhang et al.   Obesity

Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease

(2009) Diego Mastroeni et al.   PLoS One

Genetic Contribution to Variation in Cognitive Function: An fMRI Study in Twins

(2009) J. W. Koten et al.   SCIENCE

Early Research on Human Genetics Using the Twin Method: Who Really Invented the Method?

(2009) Oliver Mayo   Twin Research and Human Genetics

Genetic Dominance Influences Blood Biomarker Levels in a Sample of 12,000 Swedish Elderly Twins

(2009) Iffat Rahman et al.   Twin Research and Human Genetics

Are there genetic influences on addiction: evidence from family, adoption and twin studies

(2008) Arpana Agrawal et al.   ADDICTION

Testing Causality in the Association Between Regular Exercise and Symptoms of Anxiety and Depression

(2008) Marleen H. M. De Moor et al.   ARCHIVES OF GENERAL PSYCHIATRY

Neurobiology of cognitive aging: Insights from imaging genetics

(2008) Venkata S. Mattay et al.   BIOLOGICAL PSYCHOLOGY

Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins

(2008) L Mustelin et al.   INTERNATIONAL JOURNAL OF OBESITY

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Heritability in the genomics era — concepts and misconceptions

(2008) Peter M. Visscher et al.   NATURE REVIEWS GENETICS

Marital resemblance for obsessive–compulsive, anxious and depressive symptoms in a population-based sample

(2008) D. S. van Grootheest et al.   PSYCHOLOGICAL MEDICINE

The Eukaryotic Genome as an RNA Machine

(2008) P. P. Amaral et al.   SCIENCE

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE

Up‐regulation ofADMandSEPX1in the lymphoblastoid cells of patients in monozygotic twins discordant for schizophrenia

(2007) Chihiro Kakiuchi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Differential methylation of the X-chromosome is a possible source of discordance for bipolar disorder female monozygotic twins

(2007) Araceli Rosa et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS