The Role of Phospholipase D in Modulating the MTOR Signaling Pathway in Polycystic Kidney Disease

mTOR is a key modulator of ageing and age-related disease

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Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

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Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease

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The mTOR (Mammalian Target of Rapamycin) Kinase Maintains Integrity of mTOR Complex 2

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The Role of Autophagy in Cancer: Therapeutic Implications

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Autophagy as a target for anticancer therapy

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Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners

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New Concepts in Phospholipase D Signaling in Inflammation and Cancer

(2011) Julian Gomez-Cambronero   TheScientificWorldJOURNAL

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome

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mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

The cell biology of polycystic kidney disease

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Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

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Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

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Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

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Autophagy and Metabolism

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The phospholipase D1 pathway modulates macroautophagy

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Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors)

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Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

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Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Honokiol Suppresses Survival Signals Mediated by Ras-Dependent Phospholipase D Activity in Human Cancer Cells

(2008) A. Garcia et al.   CLINICAL CANCER RESEARCH

Tight junction composition is altered in the epithelium of polycystic kidneys

(2008) ASL Yu et al.   JOURNAL OF PATHOLOGY

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

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Regulation of macroautophagy by mTOR and Beclin 1 complexes

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