Review
Immunology
Joshua M. Moreau, Maria Velegraki, Chelsea Bolyard, Michael D. Rosenblum, Zihai Li
Summary: TGF-beta 1 plays a crucial role in the development and function of T-reg, although its pleiotropic and context-dependent activity makes it complicated.
SCIENCE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fengyi Xiao, Xishi Liu, Sun-Wei Guo
Summary: In endometriosis, Tregs produce increased amounts of effector cytokines under the influence of lesion-derived IL-33, promoting fibrogenesis in the disease.
Article
Cell Biology
Antonino Grassadonia, Vincenzo Graziano, Sara Pagotto, Angelo Veronese, Cesidio Giuliani, Marco Marchisio, Paola Lanuti, Michele De Tursi, Maurizia D'Egidio, Pietro De Marino, Davide Brocco, Patrizia Vici, Laura De Lellis, Alessandro Cama, Clara Natoli, Nicola Tinari
Summary: The study revealed that TGF-beta 1 regulates 90K expression through different molecular pathways, overcoming TSH suppression by increasing USF binding to the promoter. The elevated 90K levels induced by TGF-beta 1 may play a role in cell motility and cancer progression, independent from its impact on MHC class I. Additionally, high levels of 90K were found to be associated with increased mortality in cancer patients.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Deepraj Ghosh, Jeffrey Hsu, Kylen Soriano, Carolina Mejia Pena, Amy H. Lee, Don S. Dizon, Michelle R. Dawson
Summary: This study reveals the heterogeneity of epithelial ovarian cancer and demonstrates that tumor-promoting microenvironmental factors can alter the pattern of cancer cell clustering and induce the formation of invasive subpopulations. Peripheral cancer cells show increased invasiveness in response to these factors. Additionally, the study highlights the challenges in identifying epithelial-to-mesenchymal transition (EMT) in highly epithelial cells in response to differences in matrix mechanics, growth factor signaling, and tissue hypoxia.
Article
Immunology
Li-Hua Mo, Xiang-Qian Luo, Gui Yang, Jiang-Qi Liu, Li-Teng Yang, Zhi-Qiang Liu, Shuai Wang, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang
Summary: This study demonstrates the crucial role of CD83 in Treg differentiation in the airway mucosa and the ability of CD83/OVA-carrying exosomes to inhibit airway allergy. These findings provide a new potential approach for the treatment of airway allergic disorders.
Article
Biotechnology & Applied Microbiology
Yuebin Wang, Huike Yang, Xian Su, Anqiang Cao, Feng Chen, Peng Chen, Fangtao Yan, Huirong Hu
Summary: This study explores the expression levels of SREBP2 and ABCA1 in asthma and their effects on the development of ASMCs. The results suggest that SREBP2 activates the TLR2/NF-kappa B/NFATc1 regulatory network and promotes TGF-beta 1-induced cell movement through inhibiting ABCA1 expression.
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Immunology
Lin-Chao Li, Yang Tian, Ji Xiao, Yi Yang, Jin-Ni Wu, Yan Chen, Pu-Hong Zhang, Fang Gao-Smith, Jian-Guang Wang, Sheng-Wei Jin
Summary: The experiment showed that DEX increased the population of F4/80+Ly6G+ macrophages, which further promoted the secretion of TGF-β1, leading to a reduction in cytokine storm and an accelerated resolution of inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Weiwei Sheng, Jingtong Tang, Rongxian Cao, Xiaoyang Shi, Yuteng Ma, Ming Dong
Summary: The isoform-specific function of Numb in cancers, particularly in the initiation of epithelial-to-mesenchymal transition (EMT), is still controversial. Our study focused on the Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma (PC), showing that Numb-PRRL promotes TGF-beta 1- and EGF-induced EMT in PC by regulating TGF-beta 1-Smad2/3-Snail and EGF-induced EGFR-ERK/MAPK signaling pathways.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Viviana Volta, Sandra Perez-Baos, Columba de la Parra, Olga Katsara, Amanda Ernlund, Sophie Dornbaum, Robert J. Schneider
Summary: The differentiation of Treg cells requires non-canonical mRNA translation mechanism involving DAP5 and eIF3d, facilitated by TGF-beta-1 and downregulation of mTORC1 activity.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Shuyao Qiu, Xiangqian Luo, Lihua Mo, Shuang Zhang, Yun Liao, Li Guan, Liteng Yang, Qinmiao Huang, Dabo Liu, Pingchang Yang
Summary: This study aims to enhance the therapeutic efficacy of allergen-specific immunotherapy (AIT) in experimental allergic rhinitis (AR) by using TAFA4 as an adjuvant. The results show that TAFA4 activates dendritic cells (DCs) in the airway tissues and induces the expression of IL-10, which attenuates the allergic response in mice.
Article
Oncology
Mingyao Huang, Xin Huang, Ning Huang
Summary: Exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes HCC progression by inducing expansion of regulatory T cells (Tregs) via the miR-324-5p/TGFBR1/Smad3 axis.
Article
Cell Biology
Junrong Zou, Cong Li, Shanshan Jiang, Lingyu Luo, Xiaohua Yan, Deqiang Huang, Zhijun Luo
Summary: This study demonstrates that AMPK can inhibit the production of TGF-beta 1 through suppressing Smad3 phosphorylation and activation. Metformin can reduce the expression of TGF-beta 1, affecting the growth and survival of gastric cancer cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Thibault Colombani, Zachary J. Rogers, Khushbu Bhatt, James Sinoimeri, Lauren Gerbereux, Mohammad Hamrangsekachaee, Sidi A. Bencherif
Summary: HICs engineered with hyaluronic acid can simulate the hypoxic tumor microenvironment and promote the adaptation of tumor cells to hypoxia as well as changes in immune cells, providing a valuable tool for studying the cancer-immune cell relationship in low oxygen conditions.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Md Saimon Mia, Yagna Jarajapu, Reena Rao, Sijo Mathew
Summary: This study revealed a novel mechanism of integrin beta 1 in tumor growth by modulating the expression of kindlin-2 and TGF-beta receptor 2 signaling. Loss of integrin beta 1 affects cell proliferation and adhesion in a 3D matrix, thus impacting tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Guangfeng Ruan, Chengliang Yang, Tao Meng, Shuang Zheng, Yan Zhang, Jimin Zhu, Han Cen, Yuanyuan Wang, Zhaohua Zhu, Weiyu Han, Yujin Tang, Jia Liu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding
Summary: The study found that higher diet quality, particularly a vegetable-based diet quality, was associated with greater lower limb muscle strength, fewer depressive symptoms, and higher quality of life in knee osteoarthritis patients, rather than being related to knee joint structures and OA symptoms.
CLINICAL NUTRITION
(2021)
Article
Nanoscience & Nanotechnology
Haisi Dong, Guangqi Song, Danhui Ma, Tiedong Wang, Shisong Jing, Haimiao Yang, Ye Tao, Yong Tang, Yan Shi, Zhen Dai, Ji-min Zhu, Taotao Liu, Bingmei Wang, Xiangyang Leng, Xizhong Shen, Changfeng Zhu, Yicheng Zhao
Summary: The use of DNA self-assembled nanostructures as vehicles for delivering small interfering RNA has shown to be an effective antiviral strategy. The modified tetrahedral framework nucleic acids (tFNAs) were able to inhibit the viral proliferation of classical swine fever virus in porcine cells more effectively than free siRNAs. Additionally, a dual-targeting DNA nanostructure was constructed to further enhance the antiviral capabilities of tFNAs, showing great potential for virus therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Guangqi Song, Haisi Dong, Danhui Ma, Heming Wang, Xinran Ren, Yishen Qu, Hao Wu, Jimin Zhu, Wu Song, Ying Meng, Li Wang, Taotao Liu, Xizhong Shen, Yicheng Zhao, Changfeng Zhu
Summary: Copper is essential for various life processes but can be highly toxic at excessive levels. In multiple malignancies, including pancreatic cancer, copper overload is common, and targeting metal ion transporters for treatment may offer an effective strategy. Therapeutic tFNAs may serve as vehicles for delivering small molecular RNAs to regulate copper intake in cancer cells, potentially attenuating cancer progression.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Jia-Lei Sun, Ning-Ping Zhang, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Weinire Abuduwaili, Fu Wang, Xiang-Nan Yu, Xuan Shi, Guang-Qi Song, Hao Wu, Tao-Tao Liu, Xi-Zhong Shen, Bin Deng, Shu-Qiang Weng, Ling Dong, Ji-Min Zhu
Summary: In this study, we found that ferrous iron levels were lower in M2-like TAM compared to M1-like TAM. Loss of iron induced immunosuppressive M2 polarization of mouse macrophages. TFRC, the primary receptor for transferrin-mediated iron uptake, was overexpressed on HCC cells but not TAM. Mechanistically, HCC cells competed with macrophages for iron to upregulate the expression of M2-related genes via induction of HIF-1 alpha, thus contributing to M2-like TAM polarization. Additionally, TFRC is significantly increased in various malignancies, including HCC, and HCC patients with high TFRC levels have considerably shortened overall survival. Furthermore, TFRC is shown to be positively related to tumor-infiltrating M2 macrophages.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Letter
Rheumatology
Jimin Zhu, Guangfeng Ruan, Changhai Ding
Article
Oncology
Baikun Li, Xingyu Dong, Jimin Zhu, Ting Zhu, Xiaoxiao Tao, Daiyin Peng, Qinglin Li
Summary: This study revealed that the crosstalk between lung cancer cells and platelets can influence the proliferation, migration, and tube formation of HUVECs, potentially playing a crucial role in tumor angiogenesis by affecting or mediating changes in the properties of vascular endothelial cells (VECs).
Article
Chemistry, Physical
Jimin Zhu, Xiaoti Cui, Samuel Simon Araya
Summary: This study conducts a numerical simulation of methanol steam reforming reactions in a commercial packed-bed reactor with CuO/ZnO/Al2O3 catalyst. The results show that the inlet temperature of burner gas and tube diameter have significant effects on the temperature distribution and the formation of hot spots in the reformer tubes.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Medicine, Research & Experimental
Xiang-Nan Yu, Guang-Cong Zhang, Hai-Ning Liu, Jin-Min Zhu, Tao-Tao Liu, Guang-Qi Song, Ling Dong, Jie Yin, Xi-Zhong Shen
Summary: This study reveals the correlation between elevated expression of PRP19 and DNA damage repair in hepatocellular carcinoma (HCC). PRP19 affects the DNA damage repair ability in HCC by modulating cyclin D1 expression and function. The combination of PRP19 and cyclin D1 is valuable for predicting patient prognosis in HCC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Bilegsaikhan Enkhnaran, Guang-Cong Zhang, Ning-Ping Zhang, Hai-Ning Liu, Hao Wu, Shi Xuan, Xiang-Nan Yu, Guang-Qi Song, Xi-Zhong Shen, Ji-Min Zhu, Xiu-Ping Liu, Tao-Tao Liu
Summary: miR-106b-5p promotes cell proliferation, cell cycle progression, and resistance to sorafenib in HCC cells through the BTG3/Bcl-xL/p27 signaling pathway.
JOURNAL OF ONCOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Weinire Abuduwaili, Xiang Wang, An-Tian Huang, Jia-Lei Sun, Ru-Chen Xu, Guang-Cong Zhang, Zhi-Yong Liu, Fu Wang, Chang-Feng Zhu, Tao-Tao Liu, Ling Dong, Ji-Min Zhu, Shu-Qiang Weng, Yuhao Li, Xi-Zhong Shen
Summary: The study fabricated a nano-chemo-phototherapy drug by combining an iridium-based photosensitizer with sorafenib (IPS) via a self-assembly process. The IPS exhibited significantly improved therapeutic efficacy against tumor cells by inducing apoptosis and necrosis, inhibiting HCC cell proliferation, and promoting cell apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Zong-Rui Li, Gang Xu, Liu-Yan Zhu, Hui Chen, Ji-Min Zhu, Jian Wu
Summary: GPM6A expression is suppressed in hepatocellular carcinoma and inhibits proliferation and migration of hepatoma cells. miR-96-5p directly targets GPM6A gene and decreases its expression. GPM6A may function as a valuable biomarker for HCC progression and prognosis.
LABORATORY INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Zhi-Yong Liu, Dan-Ying Zhang, Xia-Hui Lin, Jia-Lei Sun, Weinire Abuduwaili, Guang-Cong Zhang, Ru-Chen Xu, Fu Wang, Xiang-Nan Yu, Xuan Shi, Bin Deng, Ling Dong, Shu-Qiang Weng, Ji-Min Zhu, Xi-Zhong Shen, Tao-Tao Liu
Summary: This study analyzed the immune cell infiltration levels and differentially expressed immune-related genes in sorafenib-resistant HCC. The results showed that macrophages and neutrophils were highly infiltrated, while CD8(+) T cells were downregulated in sorafenib-resistant HCC. Additionally, nalidixic acid was identified as a promising adjuvant drug for sorafenib-resistant HCC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
An-Tian Huang, Jun Du, Zhi-Yong Liu, Guang-Cong Zhang, Weinire Abuduwaili, Jia-Yan Yan, Jia-Lei Sun, Ru-Chen Xu, Tao-Tao Liu, Xi-Zhong Shen, Ling Dong, Ji-Min Zhu, Yuhao Li
Summary: This study developed a novel nanoparticle based on photothermal therapy, which can enhance the therapeutic effect and reduce the adverse effects of hepatocellular carcinoma.
Article
Oncology
Guang-Cong Zhang, Xiang-Nan Yu, Hong-Ying Guo, Jia-Lei Sun, Zhi-Yong Liu, Ji-Min Zhu, Ling Dong, Tao-Tao Liu, Xi-Zhong Shen, Jie Yin
Summary: This study identified PRP19 as a mediator of lipid metabolism reprogramming in esophageal squamous cell carcinoma (ESCC), with its upregulation correlating with poor clinical prognosis. PRP19 promotes ESCC proliferation by enhancing fatty acid synthesis through SREBF1 and stabilizing SREBF1 mRNA. Targeting PRP19 could potentially reverse metabolic reprogramming in ESCC patients.
Article
Medicine, Research & Experimental
Ru-Chen Xu, Fu Wang, Jia-Lei Sun, Weinire Abuduwaili, Guang-Cong Zhang, Zhi-Yong Liu, Tao-Tao Liu, Ling Dong, Xi-Zhong Shen, Ji-Min Zhu
Summary: In this study, a novel genetic cHCC-ICC mouse model was generated, providing insights into the molecular features and related signaling pathways of cHCC-ICC and identifying LAMB1 as a potential therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)