The absence of P2X7 receptors (P2rx7) on non-haematopoietic cells leads to selective alteration in mood-related behaviour with dysregulated gene expression and stress reactivity in mice

P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts

(2011) Pia Soronen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT

(2011) Merja Viikki et al.   NEUROSCIENCE LETTERS

Cortical Inhibition, Gamma-Aminobutyric Acid, and Major Depression: There Is Plenty of Smoke but Is There Fire?

(2010) Gerard Sanacora   BIOLOGICAL PSYCHIATRY

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion

(2010) Leanne Stokes et al.   FASEB JOURNAL

Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort

(2010) Catharina Lavebratt et al.   JOURNAL OF AFFECTIVE DISORDERS

Functional significance of P2RX7 polymorphisms associated with affective mood disorders

(2010) Ronald Sluyter et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Role of the Amygdala in Antidepressant Effects on Hippocampal Cell Proliferation and Survival and on Depression-like Behavior in the Rat

(2010) Jorge E. Castro et al.   PLoS One

P2RX7: A bipolar and unipolar disorder candidate susceptibility gene?

(2009) Elaine K. Green et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Profile of the Transcriptome Changes Induced in the Choroid Plexus by Peripheral Inflammation

(2009) Fernanda Marques et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bipolar disorder: from genes to behavior pathways

(2009) Keri Martinowich et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral origin of IL-1β production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X7 receptors

(2009) C. Csölle et al.   JOURNAL OF NEUROIMMUNOLOGY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

(2009) Sébastien Roger et al.   JOURNAL OF PSYCHIATRIC RESEARCH

The effect of antiparkinsonian drugs on oxidative stress induced pathological [3H]dopamine efflux after in vitro rotenone exposure in rat striatal slices

(2009) Elisaveta Milusheva et al.   NEUROPHARMACOLOGY

GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information

(2009) R. Nogales-Cadenas et al.   NUCLEIC ACIDS RESEARCH

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling in inflammation of the central nervous system

(2009) Francesco Di Virgilio et al.   TRENDS IN NEUROSCIENCES

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

(2008) Krisztina Hejjas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

Control of the Hypothalamo-Pituitary-Adrenal Axis in the Neonatal Period: Adrenocorticotropin and Corticosterone Stress Responses Dissociate in Vasopressin-Deficient Brattleboro Rats

(2008) Dóra Zelena et al.   ENDOCRINOLOGY

Functional evidence for presynaptic P2X7receptors in adult rat cerebrocortical nerve terminals

(2008) Susanna Alloisio et al.   FEBS LETTERS

P2Y receptor mediated inhibitory modulation of noradrenaline release in response to electrical field stimulation and ischemic conditions in superfused rat hippocampus slices

(2008) Cecília Csölle et al.   JOURNAL OF NEUROCHEMISTRY

Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain

(2008) I. Racz et al.   JOURNAL OF NEUROSCIENCE

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

(2008) A McQuillin et al.   MOLECULAR PSYCHIATRY

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

ATP-gated P2X cation-channels

(2008) Michael F. Jarvis et al.   NEUROPHARMACOLOGY

P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients

(2008) Geza Nagy et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE

A final common pathway for depression? Progress toward a general conceptual framework

(2007) Eric A. Stone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS