Cancer Associated E17K Mutation Causes Rapid Conformational Drift in AKT1 Pleckstrin Homology (PH) Domain

AKT1 (E17K) Mutation in Pancreatic Cancer

(2014) Azim Mohamedali et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Computational Investigation of Cancer-Associated Molecular Mechanism in Aurora A (S155R) Mutation

(2013) Ambuj Kumar et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Investigation of Binding Phenomenon of NSP3 and p130Cas Mutants and Their Effect on Cell Signalling

(2013) Balu K. et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Relationship between a point mutation S97C in CK1δ protein and its affect on ATP-binding affinity

(2013) Ambuj Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Drug resistance mechanism of PncA inMycobacterium tuberculosis

(2013) Vidya Rajendran et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Computational investigation of pathogenic nsSNPs in CEP63 protein

(2012) Ambuj Kumar et al.   GENE

Studies on Adaptability of Binding Residues Flap Region of TMC-114 Resistance HIV-1 Protease Mutants

(2012) Rituraj Purohit et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)

(2012) Ambuj Kumar et al.   FEBS Open Bio

In silico investigation of molecular mechanism of laminopathy caused by a point mutation (R482W) in lamin A/C protein

(2011) Vidya Rajendran et al.   AMINO ACIDS

The GRP1 PH Domain, Like the AKT1 PH Domain, Possesses a Sentry Glutamate Residue Essential for Specific Targeting to Plasma Membrane PI(3,4,5)P3

(2011) Carissa Pilling et al.   BIOCHEMISTRY

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination

(2011) H. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: An in silico analysis

(2010) Rituraj Purohit et al.   JOURNAL OF MOLECULAR MODELING

Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells

(2010) G Guo et al.   ONCOGENE

An integrated suite of fast docking algorithms

(2010) Efrat Mashiach et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

(2009) K Shoji et al.   BRITISH JOURNAL OF CANCER

AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

(2009) Dorit E. Zilberman et al.   CANCER GENETICS AND CYTOGENETICS

AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma

(2009) Yoram Cohen et al.   GYNECOLOGIC ONCOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain†

(2008) Kyle E. Landgraf et al.   BIOCHEMISTRY

The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias

(2008) I S Mahmoud et al.   BRITISH JOURNAL OF CANCER

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

(2008) M S Kim et al.   BRITISH JOURNAL OF CANCER

Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations

(2008) T. Zenz et al.   BRITISH JOURNAL OF HAEMATOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation