Review
Cell Biology
Joseena Iype, Michaela Fux
Summary: This study focuses on the role of eosinophils and basophils in allergic diseases, suggesting their potential interaction and influence on each other in allergic inflammations.
Article
Pediatrics
Juanjuan Zou, Yan Yang, Qiang Fu, Huayang Liu, Chao Zhang, Lili Liu, Yan Wang, Yanzhong Li
Summary: This study investigated the relationship between eosinophils/basophils and allergic sensitization in pediatric adenotonsillar hypertrophy (ATH). The results showed that eosinophils were significantly associated with all tested atopy allergens apart from dander, while basophils were associated with atopy to food mix. The most prevalent allergen among allergic participants was D. farinae, which may be indicative of desensitization therapy.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Luke B. Roberts, Rita Berkachy, Madina Wane, Dhiren F. Patel, Corinna Schnoeller, Graham M. Lord, Kleoniki Gounaris, Bernhard Ryffel, Valerie Quesniaux, Matthew Darby, William G. C. Horsnell, Murray E. Selkirk
Summary: Acetylcholine plays an important role in regulating immune responses and is associated with the development of various diseases. This study demonstrates that Acetylcholine derived from group 2 innate lymphoid cells (ILC2s) limits excessive pulmonary neutrophilic inflammation and enhances eosinophilia. However, depletion of Acetylcholine inhibits ILC2 activation and suppresses eosinophilic inflammation. Acetylcholine also regulates macrophage phenotype in allergic airway inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Franziska Oliveri, Michael Basler, Tata Nageswara Rao, Hans Joerg Fehling, Marcus Groettrup
Summary: This study discovered that there is a great need for controlling allergic asthma. Inhibition of immunoproteasome can alleviate airway inflammation and has the potential to target aberrant Th2 response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shuhong Wu, Zhi Wang, Yaqiong Zhu, Xinhua Zhu, Liqing Guo, Yanpeng Fu, Qingkun Zhang, Xinqi Mou, Yuehui Liu
Summary: This study demonstrates that miR-223-3p regulates eosinophil degranulation and enhances inflammation in allergic rhinitis through targeting FBXW7. The miR-223-3p/FBXW7 axis may provide a novel approach for the treatment of allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Joyceline De Volder, Annelies Bontinck, Katrien De Grove, Iris Dirven, Valerie Haelterman, Guy Joos, Guy Brusselle, Tania Maes
Summary: Experimental studies suggest that neutrophils could contribute to allergic asthma pathogenesis, that is mainly driven by type 2 immunity. Inhalation of diesel exhaust particles (DEP) is implicated in both exacerbation and development of asthma. Since exposure to DEP is associated with a neutrophilic component, we aimed to investigate how exposure to the combination of allergens and DEP modulates neutrophilic responses.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Agatha Schwarz, Rebecca Philippsen, Thomas Schwarz
Summary: Allergic contact dermatitis is a common skin disease, and its mechanisms can be studied using a murine model. This model is useful for understanding the induction and elicitation phases of the disease and has been widely utilized in research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Allergy
William E. LeSuer, Melanie Kienzl, Sergei I. Ochkur, Rudolf Schicho, Alfred D. Doyle, Benjamin L. Wright, Matthew A. Rank, Alexander S. Krupnick, Hirohito Kita, Elizabeth A. Jacobsen
Summary: This study demonstrates the reciprocal role of eosinophils in the activation of ILC2s in allergic asthma and in vitro models. Eosinophils release mediators that promote ILC2 proliferation and chemotaxis, while ILC2s also have feedback effects on eosinophils.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Suhayla H. Shareef, Kawa Amin, Christer Janson
Summary: In individuals with allergic asthma, there is an increased expression of beta-dystroglycan in airway smooth muscle and a higher number of eosinophils compared to healthy individuals. This suggests a potential role for eosinophils in airway remodeling in allergic asthma.
Article
Allergy
Erik R. Wambre, Mary Farrington, Veronique Bajzik, Hannah A. DeBerg, Marcella Ruddy, Michelle DeVeaux, Pretty Meier, David Robinson, Matt Cantor, Chengrui Huang, Jamie M. Orengo, Claire Q. Wang, Allen Radin
Summary: This study compared the clinical and immunological characteristics of asthmatic patients living with cats (WC) and those not living with cats (WoC), revealing higher levels of certain immunological markers in WC group but no clinical tolerance to natural cat exposure. The ability to live with a cat despite allergy may be driven by higher preventative medication use. This study may contribute to the development of novel therapeutics for allergy management.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Immunology
Diana C. Yanez, Ching-In Lau, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Anna Furmanski, Tessa Crompton
Summary: Foxa2 plays a significant role in lung function regulation and tissue homeostasis. Its absence in the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Foxa2 expression in T-cells is required to protect against Th2 inflammatory response and maintain the balance of effector cell differentiation and function in the lung.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Youngsoo Lee, Youjin Park, Chungsoo Kim, Eunyoung Lee, Hyun Young Lee, Seong-Dae Woo, Seng Chan You, Rae Woong Park, Hae-Sim Park
Summary: A study using a long-term real-world database found that severe asthma patients exhibit persistent eosinophilia, progressive lung function decline, and more frequent severe asthma exacerbations. The prediction model for severe asthma consists of 17 variables, including novel biomarkers, offering potential utility for both research and clinical purposes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Multidisciplinary Sciences
Jongoh Shin, Jung-Ran Noh, Donghui Choe, Namil Lee, Yoseb Song, Suhyung Cho, Eun-Jung Kang, Min-Jeong Go, Seok Kyun Ha, Jae-Hoon Kim, Yong-Hoon Kim, Kyoung-Shim Kim, Byoung-Chan Kim, Chul-Ho Lee, Byung-Kwan Cho
Summary: This study investigated the changes in gut microbial communities during aging in mouse models using various techniques such as co-housing and oral administration of probiotics. The taxonomy and functional potential of bacterial communities were characterized through 16S rRNA sequencing and shotgun metagenomic sequencing. The generated dataset expands the resources for understanding the gut microbiome related to aging and rejuvenation.
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shinichi Hayashi, Yasukazu Nakahata, Kenji Kohno, Takaaki Matsui, Yasumasa Bessho
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
JOURNAL OF CELL BIOLOGY
(2018)
Article
Plant Sciences
Yasuyo Yamaoka, Bae Young Choi, Hanul Kim, Seungjun Shin, Yeongho Kim, Sunghoon Jang, Won-Yong Song, Chung H. Cho, Hwan Su Yoon, Kenji Kohno, Youngsook Lee
Article
Biochemistry & Molecular Biology
Takushi Fujimoto, Orie Nakamura, Michiko Saito, Akio Tsuru, Masaki Matsumoto, Kenji Kohno, Kenji Inaba, Hiroshi Kadokura
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Urology & Nephrology
Jin Nakamura, Yuki Sato, Yuichiro Kitai, Shuichi Wajima, Shinya Yamamoto, Akiko Oguchi, Ryo Yamada, Keiichi Kaneko, Makiko Kondo, Eiichiro Uchino, Junichi Tsuchida, Keita Hirano, Kumar Sharma, Kenji Kohno, Motoko Yanagita
KIDNEY INTERNATIONAL
(2019)
Correction
Cell Biology
Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biology
Vivekanandan Shanmuganathan, Nina Schiller, Anastasia Magoulopoulou, Jingdong Cheng, Katharina Braunger, Florian Cymer, Otto Berninghausen, Birgitta Beatrix, Kenji Kohno, Gunnar von Heijne, Roland Beckmann
Article
Audiology & Speech-Language Pathology
Shumpei P. Yasuda, Yuta Seki, Sari Suzuki, Yasuhiro Ohshiba, Xuehan Hou, Kunie Matsuoka, Kenta Wada, Hiroshi Shitara, Yuki Miyasaka, Yoshiaki Kikkawa
Article
Cell Biology
Peixun Han, Yuichi Shichino, Tilman Schneider-Poetsch, Mari Mito, Satoshi Hashimoto, Tsuyoshi Udagawa, Kenji Kohno, Minoru Yoshida, Yuichiro Mishima, Toshifumi Inada, Shintaro Iwasaki
Article
Psychiatry
Shabeesh Balan, Tetsuo Ohnishi, Akiko Watanabe, Hisako Ohba, Yoshimi Iwayama, Manabu Toyoshima, Tomonori Hara, Yasuko Hisano, Yuki Miyasaka, Tomoko Toyota, Chie Shimamoto-Mitsuyama, Motoko Maekawa, Shusuke Numata, Tetsuro Ohmori, Tomomi Shimogori, Yoshiaki Kikkawa, Takeshi Hayashi, Takeo Yoshikawa
Summary: The study reanalyzed previously identified quantitative trait loci for prepulse inhibition (PPI) and identified a PPI-regulating Cdh23 variant, as well as a possible contribution of CDH23 to schizophrenia susceptibility.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Veterinary Sciences
Ryoko Akai, Michiko Saito, Kenji Kohno, Takao Iwawaki
EXPERIMENTAL ANIMALS
(2020)
Review
Veterinary Sciences
Kenta Wada, Shumpei P. Yasuda, Yoshiaki Kikkawa
EXPERIMENTAL ANIMALS
(2019)
Review
Veterinary Sciences
Tamio Ohno, Yuki Miyasaka, Masako Kuga, Kaori Ushida, Miyoko Matsushima, Tsutomu Kawabe, Yoshiaki Kikkawa, Masashi Mizuno, Masahide Takahashi
EXPERIMENTAL ANIMALS
(2019)
Article
Multidisciplinary Sciences
Kunie Matsuoka, Kenta Wada, Yuki Miyasaka, Shumpei P. Yasuda, Yuta Seki, Yasumasa Nishito, Hiromichi Yonekawa, Choji Taya, Hiroshi Shitara, Yoshiaki Kikkawa
SCIENTIFIC REPORTS
(2019)
Article
Biotechnology & Applied Microbiology
Chi Thanh Mai, Quynh Giang Le, Yuki Ishiwata-Kimata, Hiroshi Takagi, Kenji Kohno, Yukio Kimata
FEMS YEAST RESEARCH
(2018)