Article
Rheumatology
Hiroyuki Nakamura, Tsutomu Tanaka, Thomas Pranzatelli, Youngmi Ji, Hongen Yin, Paola Perez, Sandra A. Afione, Shyh-Ing Jang, Corrine Goldsmith, Chang Yu Zheng, William D. Swaim, Blake M. Warner, Noriyuki Hirata, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Summary: The study demonstrates that altering lysosome activity through the expression of LAMP3 in salivary gland epithelial cells can initiate an autoimmune response similar to SS, resulting in the production of autoantibodies and salivary dysfunction.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Claudia D'Agostino, Dorian Parisis, Clara Chivasso, Maryam Hajiabbas, Muhammad Shahnawaz Soyfoo, Christine Delporte
Summary: Aquaporin-5 (AQP5), a member of the aquaporins family, facilitates water flux and the movement of hydrogen peroxide and CO2. It is regulated by various mechanisms and also regulates downstream effectors involved in cellular processes. This review summarizes the current knowledge of the upstream and downstream effectors of AQP5 for a better understanding of its physiological and pathophysiological roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Akaluck Thatayatikom, Inyoung Jun, Indraneel Bhattacharyya, Kathleen Berg, Yun Jong Lee, Yoosik Kim, Abi Adewumi, Weizhou Zhang, Sthorn Thatayatikom, Ankit Shah, Casey Beal, Renee Modica, Melissa E. Elder, Seunghee Cha
Summary: The study aimed to evaluate the clinical validity of early Sjogren's syndrome autoantibodies for juvenile SS. Results showed that early SS autoantibodies had lower sensitivity and specificity, and could not effectively differentiate between JSS and non-JSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
M. Mona, S. Mondello, J. Y. Hyon, W. Saleh, K. Han, H-J Lee, Y-J Ha, E. H. Kang, Y. J. Lee, S. Cha
Summary: Anti-M3R has high specificity and sensitivity in Sjogren's syndrome, assisting in diagnosis and correlating with clinical manifestations.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Clara Chivasso, Carl Johan Hagstromer, Kristie L. Rose, Florent Lhotellerie, Lionel Leblanc, Zhen Wang, Stefania Moscato, Clement Chevalier, Egor Zindy, Maud Martin, Benoit Vanhollebeke, Francoise Gregoire, Nargis Bolaky, Jason Perret, Chiara Baldini, Muhammad Shahnawaz Soyfoo, Letizia Mattii, Kevin L. Schey, Susanna Tornroth-Horsefield, Christine Delporte
Summary: Our study reveals the interaction between AQP5 and ezrin in SGs of SS patients, which may be involved in the regulation of AQP5 trafficking and contribute to the altered localization of AQP5 in SS patients. This interaction was found in both immortalized human SG cells and human minor salivary gland acini from SS patients, suggesting a potential role of AQP5-ezrin complexes in the pathogenesis of SS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Margherita Sisto, Domenico Ribatti, Sabrina Lisi
Summary: Sjogren's syndrome is a systemic autoimmune rheumatic disorder characterized by lymphocytic infiltration of exocrine glands and production of autoantibodies to self-antigens. The molecular mechanisms underlying salivary gland dysfunction in this disease are still unclear, hindering the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Gudny Ella Thorlacius, Lina Hultin-Rosenberg, Johanna K. Sandling, Matteo Bianchi, Juliana Imgenberg-Kreuz, Pascal Pucholt, Elke Theander, Marika Kvarnstrom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Daniel Hammenfors, Kathrine Skarstein, Malin V. Jonsson, Eva Baecklund, Lara A. Aqrawi, Janicke Liaaen Jensen, Oyvind Palm, Andrew P. Morris, Jennifer R. S. Meadows, Solbritt Rantapaa-Dahlqvist, Thomas Mandl, Per Eriksson, Lars Lind, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Lars Ronnblom, Marie Wahren-Herlenius, Gunnel Nordmark
Summary: The clinical presentation of primary Sjogren's syndrome (pSS) varies widely. A multicentre study identified two patient subgroups based on the presence of SSA/SSB antibodies and genetic markers in the HLA region, with strong association signals found in HLA-DQA1 locus for the antibody-positive subgroup. Replication confirmed the association with MHC class I and II variants, indicating distinct clinical manifestations in pSS subgroups.
Article
Biochemistry & Molecular Biology
Shin-ichi Muroi, Yoichiro Isohama
Summary: Aquaporin-5 (AQP5) is selectively expressed in the apical membrane of exocrine glands and ezrin plays a role in mediating AQP5's membrane trafficking. Inhibition of ezrin selectively suppresses the translocation of AQP5 to the plasma membrane in a stimulation-dependent pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Sherri Longobardi, Charmaine Lopez-Davis, Bhuwan Khatri, Constantin Georgescu, Cherilyn Pritchett-Frazee, Christina Lawrence, Astrid Rasmussen, Lida Radfar, Robert Hal Scofield, Alan N. Baer, Susan A. Robinson, Erika Darrah, Robert C. Axtell, Gabriel Pardo, Jonathan D. Wren, Kristi A. Koelsch, Joel M. Guthridge, Judith A. James, Christopher J. Lessard, Amy Darise Farris
Summary: This study identified autoantibodies in anti-Ro/SS-A negative primary Sjogren's syndrome (SS), providing a new approach for diagnosing Ro-negative SS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ana P. Lopes, Maarten R. Hillen, Anneline C. Hinrichs, Sofie Lm Blokland, Cornelis Pj Bekker, Aridaman Pandit, Aike A. Kruize, Timothy Rdj Radstake, Joel A. van Roon
Summary: This study reveals transcriptional alterations in pSS cDC2s, including changes in type I interferon, Toll-like receptor, antigen processing, and presentation pathways. These alterations lead to aberrant antigen uptake and processing by pSS cDC2s, as well as increased proliferation of tissue-homing CD4(+) T cells. These functional changes are strongly associated with anti-SSA positivity and the presence of type I interferons.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Claudio Vitali, Antonina Minniti, Francesca Pignataro, Wanda Maglione, Nicoletta Del Papa
Summary: Despite the new biotechnological agents offering new possibilities for treating pSS, completed therapeutic trials have not yielded satisfactory results. Issues such as the extreme variability of patient phenotypes and the indolent nature of the disease leading to irreversible features in some patients have been identified as reasons for the poor outcomes. Advances in disease biomarker research are also discussed as potential solutions to improve patient selection and early diagnosis.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Maija Orjatsalo, Eemil Partinen, Gerd Wallukat, Anniina Alakuijala, Markku Partinen
Summary: The study found that patients with narcolepsy type 1 carry autoimmune antibodies that may be related to symptoms such as cataplexy, hallucinations, pain, and autonomic dysfunction. Positive autoantibodies against M2 muscarinic receptors, nociception receptors, and beta 2 adrenergic receptors may exacerbate the progression of the disease.
Article
Rheumatology
Mathijs G. A. Broeren, Jing J. Wang, Giulia Balzaretti, Patricia J. T. A. Groenen, Barbera D. C. van Schaik, Tim Chataway, Charlotte Kaffa, Sander Bervoets, Konnie M. Hebeda, Gergana Bounova, Ger J. M. Pruijn, Thomas P. Gordon, Niek De Vries, Rogier M. Thurlings
Summary: This study comparatively analysed the aberrant affinity maturation of the antinuclear and rheumatoid factor (RF) B cell repertoires in Sjogren's syndrome (SjS) patients. The results showed that the ANA and RF clones in SjS patients displayed tissue-restricted, antigen-dependent and divergent affinity maturation. The affinity maturation of RF clones deviated further during RF clone derived lymphomagenesis and during the regeneration of the autoreactive repertoire after temporary disruption by rituximab.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Ahreum Lee, Duck Kyun Yoo, Yonghee Lee, Sumin Jeon, Suhan Jung, Jinsung Noh, Soyeon Ju, Siwon Hwang, Hong Hee Kim, Sunghoon Kwon, Junho Chung, Youngnim Choi
Summary: Sjogren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. A new model has been developed to investigate the role of anti-AQP5 autoantibodies in glandular dysfunction in SS and test new therapeutics targeting autoantibody production.
Article
Immunology
Adrian Y. S. Lee, Trishni Putty, Ming-Wei Lin, Sanjay Swaminathan, Dan Suan, Tim Chataway, Rogier M. Thurlings, Tom P. Gordon, Jing Jing Wang, Joanne H. Reed
Summary: This study compared the molecular and clinical characteristics of patients diagnosed with Sjogren's syndrome (SS) with isolated anti-Ro52 and combined anti-Ro52/Ro60/La antibodies, and found that the former group exhibited higher disease activity and more complications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Young-Seok Park, Adrienne E. Gauna, Seunghee Cha
CURRENT PHARMACEUTICAL DESIGN
(2015)
Article
Microbiology
Gautam Nayar, Adrienne Gauna, Sasanka Chukkapalli, Irina Velsko, Lakshmyya Kesavalu, Seunghee Cha
Article
Rheumatology
Kaleb M. Pauley, Adrienne E. Gauna, Irina I. Grichtchenko, Edward K. L. Chan, Seunghee Cha
ARTHRITIS AND RHEUMATISM
(2011)
Review
Allergy
Byung Ha Lee, Adrienne E. Gauna, Kaleb M. Pauley, Yun-Jong Park, Seunghee Cha
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2012)
Article
Immunology
Kaleb M. Pauley, Carol M. Stewart, Adrienne E. Gauna, Lauren C. Dupre, Riya Kuklani, Annie L. Chan, Brad A. Pauley, Westley H. Reeves, Edward K. L. Chan, Seunghee Cha
EUROPEAN JOURNAL OF IMMUNOLOGY
(2011)
Article
Genetics & Heredity
Michelle L. Thompson, Adrienne E. Gauna, Matthew L. Williams, David A. Ray
Correction
Genetics & Heredity
Michelle L. Thompson, Adrienne E. Gauna, Matthew L. Williams, David A. Ray
Article
Immunology
Adrienne E. Gauna, Seunghee Cha
Article
Multidisciplinary Sciences
Yun-Jong Park, Jin Koh, Adrienne E. Gauna, Sixue Chen, Seunghee Cha
Article
Rheumatology
Adrienne E. G. Williams, Kevin Choi, Annie L. Chan, Yun Jong Lee, Westley H. Reeves, Michael R. Bubb, Carol M. Stewart, Seunghee Cha
ARTHRITIS RESEARCH & THERAPY
(2016)