Cytotoxic Activity and Apoptosis-Inducing Potential of Di-spiropyrrolidino and Di-spiropyrrolizidino Oxindole Andrographolide Derivatives

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

(2012) Jing Zhou et al.   Autophagy

The genotoxicity and cytotoxicity assessments of andrographolide in vitro

(2012) Yusrizam Sharifuddin et al.   FOOD AND CHEMICAL TOXICOLOGY

Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis

(2012) P. Pratheeshkumar et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation canin vitroinduce tumor cell death forms with immunogenic potential

(2012) Benjamin Frey et al.   Journal of Immunotoxicology

Estrogen receptor beta growth-inhibitory effects are repressed through activation of MAPK and PI3K signalling in mammary epithelial and breast cancer cells

(2012) C Z Cotrim et al.   ONCOGENE

Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

(2011) Yong-Wei Zhang et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)

(2010) Erik Norberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthesis, cytotoxicity, and structure–activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent

(2010) Bimolendu Das et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Halogen Atoms in the Modern Medicinal Chemistry: Hints for the Drug Design

(2010) Marcelo Hernandes et al.   CURRENT DRUG TARGETS

Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary

(2010) E. A. Tanner et al.   DEVELOPMENT

Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway

(2010) Yi-Chieh Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Over-expression of the X-linked inhibitor of apoptosis protein (XIAP) delays serum deprivation-induced apoptosis in CHO-K1 cells

(2010) Jane C.J. Liew et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells

(2010) R Puca et al.   ONCOGENE

Chemistry of andrographolide: formation of novel di-spiropyrrolidino and di-spiropyrrolizidino-oxindole adducts via one-pot three-component [3+2] azomethine ylide cycloaddition

(2010) Abhijit Hazra et al.   TETRAHEDRON LETTERS

Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress

(2008) Sreeparna Neogy et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Andrographolide Up-Regulates Cellular-Reduced Glutathione Level and Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury

(2008) A. Y. H. Woo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY