Review
Biochemistry & Molecular Biology
Anna Cecchele, Greta Chiara Cermisoni, Elisa Giacomini, Monica Pinna, Paola Vigano
Summary: This article provides a review on the cellular and molecular heterogeneity of embryo fragmentation, describing different embryo fragment-like cellular structures and their possible functions and origins. The occurrence of embryo fragmentation is associated with various mechanisms that may have different effects on embryo competence. Therefore, the practice of removing fragments from the embryo before transfer to improve implantation potential should be reconsidered based on the current observations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
Rosa Tundis, Jayanta Kumar Patra, Marco Bonesi, Subrata Das, Rajat Nath, Anupam Das Talukdar, Gitishree Das, Monica Rosa Loizzo
Summary: Despite advancements in treatment strategies, cancer remains a leading cause of death globally. Therefore, the main focus should be on early cancer diagnosis, optimal therapeutic strategies, and the search for more effective molecules. This review comprehensively summarizes the potential anti-cancer properties of andrographolide, highlighting its mechanisms of action, pharmacokinetics, and potential side effects, while discussing future perspectives, challenges, and limitations of use.
Article
Pharmacology & Pharmacy
Junqian Zhang, Chunjie Li, Li Zhang, Yongqing Heng, Tong Xu, Yunjing Zhang, Xihui Chen, Robert M. Hoffman, Lijun Jia
Summary: Andrographolide (AD) inhibits the proliferation of lung cancer cell lines and induces apoptosis in human lung adenocarcinoma cells by activating the ATF4/Noxa axis, supporting its potential as a candidate for chemotherapy in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Yaya Wang, Ruiyi Zhao, Xinyue Zhu, Hong Gao, Can Gong, Xiaoyan Liu, Haixia Zhang
Summary: Accurate evaluation of cell death types is crucial for pharmacological and pathological research. In this study, a novel fluorescent probe PNE-Lyso was designed and synthesized, which could distinguish healthy cells from dead cells by targeting the lysosome and evaluating lysosomal hexosaminidase activity. Additionally, PNE-Lyso could differentiate apoptotic and necrotic cells by visualizing lysosome morphology adjusted by the integrity of the lysosome membrane. This work represents the first time cell death types have been distinguished based on a single fluorescent probe.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yaya Wang, Ruiyi Zhao, Xinyue Zhu, Hong Gao, Can Gong, Xiaoyan Liu, Haixia Zhang
Summary: PNE-Lyso is a novel activatable fluorescent probe designed to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals, which can distinguish dead cells from healthy cells based on a dual-color mode. It has important implications for pharmacological and pathological research.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sunil P. Trivedi, Arun Ratn, Yashika Awasthi, Manoj Kumar, Abha Trivedi
Summary: Sub-lethal exposure to dichlorvos induces oxidative stress, genetic instability, and apoptosis in Channa punctatus, along with impairments in biochemical, histopathological, and genetic transcription. Elevated levels of reactive oxygen species (ROS), as well as alterations in antioxidant enzyme activities and other biochemical parameters, were observed in fish exposed to sub-lethal concentrations of dichlorvos. Additionally, up-regulation of genes associated with apoptosis and DNA damage response pathways further indicates the genotoxic potential of dichlorvos on aquatic organisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhen Li, Zehui Li, Zhenyue Chen, He Sun, Zhagen Yuan, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: Andro has shown neuroprotective effects against spinal cord injury (SCI) by reducing apoptosis, oxidative stress, and inflammation, promoting axonal regeneration and remyelination, leading to tissue repair and functional recovery.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jingtao Jiang, Jie Jin, Junsheng Lou, Jiafeng Li, Hongqiang Wu, Sheng Cheng, Chengji Dong, Hongyu Chen, Weiyang Gao
Summary: Random-pattern skin flap replantation is commonly used for tissue reconstruction, and Andro has been shown to enhance flap viability by promoting angiogenesis, inhibiting apoptosis, and reducing oxidative stress. Additionally, Andro increases autophagy levels, which contribute to improved flap survival, and this effect can be reversed by the autophagy inhibitor 3-methyladenine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thikryat Neamatallah, Azizah M. M. Malebari, Abdulmohsin J. J. Alamoudi, Syed Nazreen, Mohammad Mahboob Alam, Hawazen H. H. Bin-Melaih, Osama A. A. Abuzinadah, Shaimaa M. M. Badr-Eldin, Gharam Alhassani, Lamar Makki, Mohammed Z. Z. Nasrullah
Summary: In this study, an optimized AG-PTMs formulation was prepared, which significantly inhibited the proliferation of liver cancer cells HepG2 through enhanced cellular uptake, cell cycle arrest and mitochondrial-dependent apoptosis.
Article
Biochemistry & Molecular Biology
Wei Cai, Jieyi Li, Cheng Chen, Jiajia Wu, Jiabin Li, Xiaowen Xue
Summary: The study synthesized a series of 1,2-didehydro-3-ox-andrographolide derivatives based on two Michael acceptors, with compound 10b showing the most significant inhibitory activities against HCT116 and MCF-7 cells. Mechanistic investigation indicated that compound 10b inhibited HCT116 cell proliferation by inducing apoptosis and arresting cell cycle progression in a concentration-dependent manner.
BIOORGANIC CHEMISTRY
(2021)
Article
Cell & Tissue Engineering
Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian, Jing Zhu
Summary: This study aimed to illustrate the protective effect of andrographolide (AG) against glucose and serum deprivation under hypoxia (GSDH)-induced cell injury in BMSCs and investigate the possible underlying mechanisms. The results showed that AG can protect BMSCs from GSDH-induced cell injury by increasing cell viability and proliferation, enhancing mitochondrial function, and reducing apoptosis and oxidative stress.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Shuai Shi, Xinyu Ji, Jingjing Shi, Shuqing Shi, Fei She, Qiuyan Zhang, Yu Dong, Hanming Cui, Yuanhui Hu
Summary: The study successfully identified AG's potential targets and pathways in atherosclerosis, showing that AG may regulate NF-??B/CEBPB/PPARG signaling to alleviate the condition.
BIOSCIENCE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Smita Yadav, Faiyaz Ahmad, Sushma Rathaur
Summary: This study demonstrates the potential of andrographolide in inhibiting motility and viability of filarial parasites, inducing apoptosis, and competitively inhibiting enzyme activity. Therefore, andrographolide could be a promising new drug for lymphatic filariasis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Minggang Tian, Baoli Dong, Zheming Zhang, Junling Yin, Weiying Lin
Summary: A new fluorescent probe mPTP-F has been successfully designed to monitor the opening of mPTP in cellular native status. This probe can serve as an important tool for studying areas such as ischemia-reperfusion injury and cell apoptosis.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Sok Kuan Wong, Kok-Yong Chin, Soelaiman Ima-Nirwana
Summary: This review summarizes the biological activities and mechanisms of action of Andrographis paniculata and andrographolide in cardiovascular health, showing their protective effects against myocardial injury through various pathways. Further validation in human clinical trials is needed to confirm their therapeutic potential.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)