Endoglin Requirement for BMP9 Signaling in Endothelial Cells Reveals New Mechanism of Action for Selective Anti-Endoglin Antibodies

A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer

(2012) L. S. Rosen et al.   CLINICAL CANCER RESEARCH

Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

(2012) Laurens A. van Meeteren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Insights into Endoglin Ligand Recognition and Binding

(2012) Aaron Alt et al.   PLoS One

BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain

(2011) Marie Bidart et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

(2011) Laurens A. van Meeteren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth

(2011) Roselyne Castonguay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoglin promotes TGF-β/Smad1 signaling in scleroderma fibroblasts

(2011) Erin Morris et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The physiological role of endoglin in the cardiovascular system

(2010) José M. López-Novoa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

(2010) Sara I. Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ALK1-Fc Inhibits Multiple Mediators of Angiogenesis and Suppresses Tumor Growth

(2010) D. Mitchell et al.   MOLECULAR CANCER THERAPEUTICS

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Endoglin-Targeted Cancer Therapy

(2010) Ben K. Seon et al.   Current Drug Delivery

The emerging role of TGF-β superfamily coreceptors in cancer

(2009) Carmelo Bernabeu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

(2009) E. S. Shao et al.   BLOOD

Emerging role of bone morphogenetic proteins in angiogenesis

(2009) Laurent David et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Transforming Growth Factor β Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

(2009) Katharine H. Wrighton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mural Cell Associated VEGF Is Required for Organotypic Vessel Formation

(2009) Lasse Evensen et al.   PLoS One

HHT is not a TGF disease

(2008) S. Bailly   BLOOD

Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor

(2008) Laurent David et al.   CIRCULATION RESEARCH

Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy

(2008) N. A. Dallas et al.   CLINICAL CANCER RESEARCH

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

Anti-tumor activity of an anti-endoglin monoclonal antibody is enhanced in immunocompetent mice

(2008) Masanori Tsujie et al.   INTERNATIONAL JOURNAL OF CANCER

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Endoglin-Mediated Vascular Remodeling: Mechanisms Underlying Hereditary Hemorrhagic Telangiectasia

(2008) Franck Lebrin et al.   TRENDS IN CARDIOVASCULAR MEDICINE