Article
Biochemistry & Molecular Biology
Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In this study, the preventive effects of intrathecal bupivacaine administration against neuropathic pain were investigated. Bupivacaine attenuated pain behaviors and inflammatory alternations by suppressing microglia M1 polarization and pro-inflammatory cytokine expression. The Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappa B inflammatory axes were identified as key players in microglia polarization and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Wenyao Wu, Xianwei Zhang, Shuo Wang, Tian Li, Quanshui Hao, Shiyong Li, Wenlong Yao, Rao Sun
Summary: The cGAS-STING pathway may be a potential therapeutic target for treating neuropathic pain by suppressing microglial M1 polarization. Activation of the cGAS-STING pathway occurs mainly in neurons and microglia, and inhibition of the pathway can suppress microglial M1 polarization and improve mechanical allodynia.
Article
Nanoscience & Nanotechnology
Quangdon Tran, Thuy Linh Pham, Hyo Jung Shin, Juhee Shin, Nara Shin, Hyeok Hee Kwon, Hyewon Park, Song I. Kim, Seoung Gyu Choi, Junhua Wu, Van T. H. Ngo, Jin Bong Park, Dong Woon Kim
Summary: The study found that nanoparticles of fexofenadine can alleviate pain sensitivity in rats with spinal nerve ligation and inhibit microglial activation and inflammatory signaling in the spinal cord, showing promise as a long-term treatment for neuropathic pain.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Liya V. Tret'yakova, Alexey A. Kvichansky, Ekaterina S. Barkovskaya, Anna O. Manolova, Alexey P. Bolshakov, Natalia V. Gulyaeva
Summary: The effects of glucocorticoid and mineralocorticoid receptor modulation on acute neuroinflammatory response in the hippocampus of male Wistar rats were investigated. Activation of the glucocorticoid receptor suppressed expression of inflammatory genes, while inhibition of the receptors had no significant effect on the inflammatory response. These findings suggest that glucocorticosteroids ambiguously regulate specific aspects of neuroinflammatory response in the rat hippocampus at the molecular and cellular levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Neurosciences
Le Ma, Shiyu Peng, Jinbao Wei, Mengjing Zhao, Khalil Ali Ahmad, Jinghong Chen, Yong-Xiang Wang
Summary: This study investigated the regulation of pain hypersensitivity by IL-10 and GLP-1R agonist exenatide in neuropathic rats, showing that spinal microglial expression of beta-endorphin mediates the inhibitory effects.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Medicinal
Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Jiang Zhao, Qudong Lu, Jingzhen Zhu, Longkun Li, Shanhong Yi, Jie Xu
Summary: The role of CXCR4 in colon-bladder cross-organ sensitization was studied in this experiment. The results showed that treatment targeting the CXCR4/ERK pathway might provide a potential new approach for the comorbidity between the digestive system and the urinary system.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Zhifeng Huang, Zijing Ding, Yangting Xu, Caiyun Xi, Liqiong He, Hui Luo, Qulian Guo, Changsheng Huang
Summary: Regulation of gene transcription in the spinal dorsal horn (SDH) through the transcription factor STAT2 plays a crucial role in the development of neuropathic pain. Chronic constriction injury of the rat sciatic nerve led to the downregulation of nuclear STAT2 in the SDH, which was associated with increased microglial activation and the development of neuropathic pain. In addition, siRNA-induced downregulation of STAT2 promoted microglial activation and pro-inflammatory cytokine expression in the SDH. Restoring nuclear expression of STAT2 could potentially be a therapeutic pathway for treating neuropathic pain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaswanth Kuthati, Vaikar Navakanth Rao, Wei-Hsiu Huang, Prabhakar Busa, Chih-Shung Wong
Summary: The dipeptidyl peptidase-4 inhibitor teneligliptin can alleviate morphine analgesic tolerance (MAT) and reduce microglial cell activation in the dorsal horn of rats with diabetic neuropathic pain (DNP). This study suggests that teneligliptin may be a new approach for treating DNP.
Article
Clinical Neurology
Robert E. Sorge, Ying Si, Lyse A. Norian, Abhishek Guha, Grace E. Moore, L. Burt Nabors, Natalia Filippova, Xiuhua Yang, Reed Smith, Rajeshwari Chellappan, Peter H. King
Summary: Microglial activation and the production of pro-inflammatory mediators play a significant role in neuropathic pain following peripheral nerve injury. This study demonstrates that inhibiting HuR, a RNA binding protein, attenuates the production of these inflammatory mediators and reduces mechanical allodynia in mice. The systemic administration of SRI-42127, a novel HuR inhibitor, suppresses neuroinflammatory responses and shows promise as a new direction for the treatment of neuropathic pain.
Article
Cardiac & Cardiovascular Systems
Zachary Ladd, Gang Su, Joseph Hartman, Guanyi Lu, Sara Hensley, Gilbert R. Upchurch Jr, Ashish K. Sharma
Summary: This study explored the regulation role of spironolactone in endothelial cell-mediated ATP release for the mitigation of abdominal aortic aneurysm (AAA) formation. The results showed that spironolactone treatment could decrease the diameter of the abdominal aorta, reduce elastic fiber disruption, and immune cell infiltration. Furthermore, it also suppressed the expression of pro-inflammatory cytokines, inhibited MMP2 activity, and reduced ATP content in the aortic tissue. In vitro experiments demonstrated that spironolactone attenuates extracellular ATP release from endothelial cells, leading to decreased macrophage activation and smooth muscle cell-dependent vascular remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Charlie H. T. Kwok, Yuta Kohro, Michael Mousseau, Melissa S. O'Brien, John R. Matyas, Jason J. McDougall, Tuan Trang
Summary: Painful injury increases afferent input, enhancing the activity of central nociceptive circuits through neuron-neuron and neuron-glia interactions. Microglia play a crucial role in the pathogenesis of chronic pain, and peripheral joint injury signals the CNS to engage spinal microglial responses.Joint nociceptors are activated by early peripheral joint injury, triggering a central spinal microglial response and potentially modulating communication between sensory neurons and spinal microglia through ATP signaling during joint degeneration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Behavioral Sciences
Seyedehdelaram Ghalebandi, Fatemeh Zareie, Kobra Askari, Jale Yuzugulen, Abbas Haghparast
Summary: Orexins or hypocretins, produced in the lateral hypothalamus, play a role in pain modulation and responsiveness to stressful stimuli. The study found that orexin receptors in the hippocampal CA1 region are involved in stress-induced analgesia, and blocking these receptors attenuates the analgesic effect of forced swim stress.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Yifan Yang, Qing Sheng, Zuoming Nie, Lili Liu, Wenping Zhang, Guiqian Chen, Fei Ye, Liyun Shi, Zhengbing Lv, Junjing Xie, Dan Wang
Summary: Daphnetin shows significant alleviating effects on inflammatory pain induced by complete Freund's adjuvant in mice, through inhibition of spinal glial activation and reduced expression of spinal pro-inflammatory cytokines, possibly by negative regulation of the NF-rB pathway and activation of the Nrf2/HO-1 signaling pathway. These findings suggest the potential application of Daphnetin in treating chronic inflammatory pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)