Article
Cell Biology
Hengjie Wang, Shuai Zhu, Xinghan Wu, Yuan Liu, Juan Ge, Qiang Wang, Ling Gu
Summary: Maternal obesity can lead to adverse reproductive outcomes, with reduced NAMPT expression and NAD(+) content found in oocytes from obese mice. NAMPT deficiency disrupts the maturation and meiotic process in oocytes, while supplementation with nicotinic acid can improve the quality of oocytes from obese mice.
Article
Multidisciplinary Sciences
Daniel Gonzalez-Bohorquez, Isabel M. Gallego Lopez, Baptiste N. Jaeger, Sibylle Pfammatter, Megan Bowers, Clay F. Semenkovich, Sebastian Jessberger
Summary: The fate and behavior of neural progenitor cells play crucial roles in mammalian brain development. This study reveals the importance of de novo lipogenesis, mediated by fatty acid synthase (FASN), in regulating progenitor cell polarity and proliferation during mouse and human brain development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Siyuan Tang, Miguel Garzon Sanz, Oliver Smith, Andreas Kraemer, Daniel Egbase, Paul W. Caton, Stefan Knapp, Sam Butterworth
Summary: The cofactor NAD thorn plays a crucial role in physiological processes and enhancing healthy aging. Recent studies have shown that NAMPT activators can increase NAD thorn levels and have beneficial effects. The structure activity relationships of these activators were evaluated and it was hypothesized that they act via a through-water interaction in the NAMPT active site, leading to the design of a urea-class NAMPT activator with similar or greater activity compared to known analogues.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Dorothee Houry, Arne Raasakka, Eugenio Ferrario, Marc Niere, Ersilia Bifulco, Petri Kursula, Mathias Ziegler
Summary: In this study, the mechanism of increased substrate affinity of phosphorylated NAMPT is revealed, which includes the coordination of Mg2+ by phospho-His247 to stabilize PRPP in a position favorable for catalysis. Additionally, a stretch of 10 amino acids found only in NAMPTs from deuterostomes is shown to enhance conformational plasticity and stabilize the chemically unstable phosphorylation of His247. Overall, this study provides a structural basis for the important function of NAMPT in recycling Nicotinamide into NAD biosynthesis with high affinity.
JOURNAL OF STRUCTURAL BIOLOGY
(2023)
Article
Oncology
Xiaoju Lai, Yanling Liang, Jie Jin, Hanyun Zhang, Zhicong Wu, Guihuan Li, Jinxiang Wang, Zhishuai Zhang, Hua Chen, Fangyin Zeng, Fan Deng
Summary: PKCe regulates proliferation of prostate cancer cells by modulating PKM2-mediated de novo lipogenesis and may serve as a potential therapeutic target for prostate cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, General & Internal
Nadia Sawicka-Gutaj, Hanna Komarowska, Dawid Gruszczynski, Aleksandra Derwich, Anna Klimont, Marek Ruchala
Summary: This study aimed to assess the clinical usefulness of visfatin/NAMPT serum level in discriminating between adrenocortical carcinomas (ACC) and benign adrenal tumors. The results showed that patients with ACC had significantly higher visfatin serum concentrations compared to patients with benign adrenocortical tumors, and visfatin levels were associated with clinical stage and metastases in ACC patients. Serum visfatin/NAMPT could potentially serve as a biomarker for distinguishing ACC, but further research is needed to confirm its accuracy and reliability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Qi-Hai Wang, Yan Li, De-Yu Dou, Rui Wang, Tian-Tian Jiang, Lin Wang, Ming-Qiang Li, Opeyemi Joshua Olatunji, Jian Zuo
Summary: Supplementation of NMN exacerbated the severity of AIA in rats, deteriorated MMP3-controlled tissue damages, and altered the immune profile by increasing Th17/Treg cells ratio. Up-regulation of NAMPT in PBMCs from NMN-treated rats was accompanied by significant increase in iNOS, MCP-1, and IL-1 beta expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
Summary: This study found that CD36 plays a role in the development of NAFLD by facilitating the uptake of free fatty acids and enhancing de novo lipogenesis in hepatocytes. CD36 forms a complex with INSIG2, disrupting the interaction between SCAP and INSIG2, leading to the translocation of SREBP1 for processing. These findings provide new evidence for targeting CD36 as a potential therapeutic approach for NAFLD.
MOLECULAR METABOLISM
(2022)
Article
Nutrition & Dietetics
Woo Yong Park, Gahee Song, Joon Hak Noh, Taegon Kim, Jae Jin Kim, Seokbeom Hong, Jinbong Park, Jae-Young Um
Summary: The study investigated the pharmacological effect of RSWE on alcoholic fatty liver disease (AFLD) and found that RSWE has the potential to improve AFLD by inhibiting de novo lipogenesis in the liver. Supplementation with RSWE decreased liver fat accumulation and improved tissue structure in both mouse and cell models.
Article
Medicine, Research & Experimental
Qifeng Shi, Liang Xu, Xiangyi Zeng
Summary: Disc degeneration is the main cause of various diseases such as discogenic low back pain, degenerative stenosis of spinal canal, and lumbar spondylolisthesis. The study reveals the involvement of nicotinamide phosphoribosyl transferase (Nampt) and sirtuin 1 (SIRT1) in the regulation of intervertebral disc degeneration (IVDD) and suggests their potential as therapeutic targets.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Xiangyun Tan, Yi Sun, Liang Chen, Junjie Hu, Yan Meng, Ming Yuan, Qi Wang, Shan Li, Guohua Zheng, Zhenpeng Qiu
Summary: This study aimed to evaluate the therapeutic efficacy of caffeine in a NASH mouse model. The results showed that caffeine improved hepatic steatosis and inflammatory injury by inhibiting two signaling pathways and reducing the production of proinflammatory mediators. These findings suggest that caffeine may be beneficial in the prevention and therapy of NASH.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Ting Li, Xiaojie Liu, Xiaoyi Long, Yangyou Li, Jin Xiang, Yuanxia Lv, Xiaoyang Zhao, Shaoqing Shi, Wei Chen
Summary: In this study, the role of brexpiprazole in cell proliferation and lipogenesis in colorectal cancer (CRC) was investigated. Brexpiprazole was found to significantly suppress cell proliferation and lipogenesis in CRC, possibly through the inhibition of SREBP1 and the stimulation of AMPK.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Bettina Geidl-Flueck, Philipp A. Gerber
Summary: This article examines the impact of sugar/fructose intake on hepatic de novo lipogenesis (DNL) and suggests that fructose is a more potent inducer of hepatic lipogenesis than glucose. The disruption of fructose metabolism under pathological conditions may lead to increased expression of fructolytic and lipogenic enzymes, contributing to ectopic fat deposition and impairment of various metabolic processes.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yawen Lu, Yimeng Chen, Wenxin Hu, Meng Wang, Xiaodong Wen, Jie Yang
Summary: This study aimed to investigate the role and mechanism of acetyl-CoA synthetase 2 (ACSS2) in acute alcohol-induced lipogenesis. The results showed that alcohol challenge induced hepatic lipid deposition and upregulated lipogenic genes, while ACSS2 knockdown blocked histone acetylation and lipogenic gene induction. Ethanol metabolism promoted ACSS2 nuclear import and supported lipogenesis via H3K9 acetylation. In alcohol-feeding mice, liver-specific ACSS2 knockdown blocked the interaction between PCAF and H3K9 and suppressed lipogenic gene induction.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Mohsin Ali Khan, Zaw Ali Khan, Fouzia Shoeb, Ghizal Fatima, Rizwan Hasan Khan, Mohammad M. Khan
Summary: Patients with Alzheimer's disease often have insulin resistance in both peripheral tissues and the brain, which can contribute to cognitive dysfunction. Elevated levels of intracellular fatty acids, specifically saturated fatty acids, could induce insulin resistance and inflammation. Regulating de novo lipogenesis may be an effective therapy for improving insulin sensitivity and cognitive function in Alzheimer's disease patients.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Mohammed Abdulhaleem, Hannah Johnston, Ralph D'Agostino, Claire Lanier, Michael LeCompte, Christina K. Cramer, Jimmy Ruiz, Thomas Lycan, Hui-Wen Lo, Kuonosuke Watabe, Stacey O'Neill, Christopher Whitlow, Jaclyn J. White, Stephen B. Tatter, Adrian W. Laxton, Jing Su, Michael D. Chan
Summary: This retrospective study compared the clinical outcomes of lung cancer patients receiving immune checkpoint inhibitors and stereotactic radiosurgery with a historical control group. The results showed that patients receiving immunotherapy had improved overall survival and local control compared to the control group.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Lina Merjaneh, Lawrence M. Dolan, Cynthia Suerken, Ralph Dagostino, Giuseppina Imperatore, Sharon Saydah, Alissa J. Roberts, Santica M. Marcovina, Elizabeth J. Mayer-Davis, Dana Dabelea, Jean M. Lawrence, Catherine Pihoker
Summary: This study assessed changes in diabetes autoantibodies (DAs) over time in children and young adults with diabetes. It found that a decrease in the number of positive DAs was associated with longer diabetes duration and younger age at diagnosis. Measuring DAs may aid in diabetes classification but is unlikely to predict the clinical course.
PEDIATRIC DIABETES
(2022)
Article
Public, Environmental & Occupational Health
Youngdeok Kim, R. Lee Franco, Alexander R. Lucas, Arnethea L. Sutton, Jessica G. LaRose, Jonathan Kenyon, Jeremy Via, Richard K. Cheng, Ralph B. D'Agostino, Vanessa B. Sheppard, W. Gregory Hundley
Summary: The study aimed to examine the prevalence of cardiovascular diseases among breast cancer survivors. The results showed that breast cancer survivors are at risk of cardiovascular diseases, and this risk is associated with factors such as age, education, marital status, menopausal, and physical activity levels.
AMERICAN JOURNAL OF HEALTH PROMOTION
(2022)
Review
Clinical Neurology
Beddome C. Allen, Sahil Kapoor, Anthony Anzalone, Kirby P. Mayer, Stacey Q. Wolfe, Pam Duncan, Andrew W. Asimos, Ralph D'Agostino Jr, James Tripp Winslow, Aarti Sarwal
Summary: This study reviewed the feasibility of transcranial ultrasonography (TCU) as a diagnostic tool for evaluating intracranial pathology in critical care or austere settings. The results showed that TCU has reasonable sensitivity and specificity in detecting intracranial pathology including intracranial hemorrhage and tumors. This suggests that TCU can be clinically valuable in remote areas or where standard imaging is unavailable.
JOURNAL OF NEUROIMAGING
(2023)
Article
Health Care Sciences & Services
Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore
Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Oncology
Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu
Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.
Article
Clinical Neurology
Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal
Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).
JOURNAL OF NEUROIMAGING
(2023)
Article
Endocrinology & Metabolism
Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D'Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening
Summary: This study examined the relationship between diabetes complications and cognitive dysfunction in young adults with type 1 or type 2 diabetes. The results showed that hypoglycemia and peripheral neuropathy were associated with cognitive deficits in type 1 diabetes, while high blood pressure was associated with cognitive deficits in type 2 diabetes. These findings provide insights for targeting specific factors to mitigate cognitive issues in young people with diabetes.
PEDIATRIC DIABETES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
W. Gregory Hundley, Ralph D'Agostino
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine A. A. Sauder, Deborah H. H. Glueck, Kylie K. K. Harrall, Ralph D'Agostino, Lawrence M. M. Dolan, Abbi D. D. Lane, Angela D. D. Liese, Eva Lustigova, Faisal S. S. Malik, Santica Marcovina, Elizabeth Mayer-Davis, Amy Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. S. Shah, Elaine M. M. Urbina, Lynne E. E. Wagenknecht, Stephen R. R. Daniels, Dana Dabelea
Summary: This study examined arterial stiffness in individuals with type 1 diabetes and explored the differences between Hispanic, non-Hispanic Black, and non-Hispanic White individuals. The results showed that cardiovascular and socioeconomic factors explain a quarter of the racial and ethnic differences in arterial stiffness, but non-Hispanic Black individuals still experienced higher arterial stiffness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Yin Liu, Margaret R. R. Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L. L. Kucera, Lance D. D. Miller, Wencheng Li, Michael D. D. Chan, Michael Farris, Jing Su, Qianqian Song, Dawen Zhao, Arvind Chandrasekaran, Fei Xing
Summary: This study reveals that tumor-infiltrating neutrophils secrete high levels of lipocalin 2 (LCN2), which enhances the stemness of tumor cells in brain metastasis. The interactions between neutrophils and brain metastatic cells provide new insights into treating brain metastasis.
Article
Oncology
Margaret R. Smith, Yuezhu Wang, Ralph D'Agostino, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D. Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N. Abdulhaleem, Michael D. Chan, Michael Farris, Jing Su, Kathryn F. Mileham, Fei Xing
Summary: Different therapy options are used for NSCLC based on tumor stage and genetic mutations. However, biomarkers to guide treatment selection are limited. A study collected clinical and sequencing data from 524 NSCLC patients to examine the association between mutation profiles and treatment response. Mutation composite scores (MCS) were generated for different treatments, and MCS showed superior predictive power compared to other biomarkers in immune therapy-treated patients.
NPJ PRECISION ONCOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Leila Mabudian, Nathaniel S. O'Connell, Ralph B. D'Agostino, Emily Heiston, Julia A. Fleshman, Daniel Miller, Kerryn Reding, Kathryn E. Weaver, Amy Ladd, William Ofori Ntim, Heidi D. Klepin, Emily Dressler, Tonya Calhoun, Jennifer H. Jordan, Mary Helen Hackney, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)