Article
Oncology
Daniel J. George, Ateesha F. Mohamed, Jui-Hua Tsai, Milad Karimi, Ning Ning, Sayeli Jayade, Marc Botteman
Summary: This study investigated the treatment preferences of mCRPC patients in the US and found that improving overall survival is the highest priority for patients. However, they are willing to make tradeoffs to reduce adverse reactions and side effects.
Article
Endocrinology & Metabolism
Desiree M. Straign, Claire L. Ihle, Meredith D. Provera, Philip Owens
Summary: Prostate cancer bone metastases are common and often lead to painful skeletal events, with the BMP and TGF beta signaling pathways showing distinct effects in lytic or blastic bone lesions. Inhibiting BMP with DMH1 treatment restricts colonization of cancer cells in bone and preserves bone health. This suggests that profiling bone lesions in metastatic prostate cancer can help identify therapeutic targets to improve treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Yaoyuan Li, Yanju Bao, Honggang Zheng, Yinggang Qin, Baojin Hua
Summary: Src protein plays a significant role in cancer-induced bone pain, promoting tumor growth and metastasis as well as participating in the formation and transmission of pain signals. Both basic experimentation and clinical research have shown promising potential for the prevention and treatment of CIBP.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tingting Lv, Zijie Li, Dehua Wang, Xiaojin Guo, Xiaokuan Zhang, Jing Cao, Zhiyu Wang
Summary: This review summarizes the role of exosomes in PCa bone metastasis, including their influence on bone quality and structure, modulation of bone marrow microenvironment, and potential clinical applications in treatment strategies.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Paola Maroni, Paola Bendinelli, Alessandro Fulgenzi, Anita Ferraretto
Summary: Bone metastasis is a severe complication of common cancers like breast and prostate cancer, reducing survival rates and quality of life. Following a Mediterranean diet can prevent cancer and improve patient health, potentially impacting the spread of cancer to the bones.
Review
Oncology
Anne Natalie Prigol, Michele Patricia Rode, Fernanda da Luz Efe, Najla Adel Saleh, Tania Beatriz Creczynski-Pasa
Summary: Bone metastatic prostate cancer is associated with high mortality risks, and miRNA expression changes are closely related to the development, diagnosis, and treatment of this condition. Recent studies focus on the roles of miRNAs in bone metastasis, including their impact on metastasis-related processes and abnormal bone remodeling. Moreover, miRNAs can be harnessed for developing treatment tools and serve as noninvasive biomarkers for detecting prostate cancer metastasis. Overall, miRNA expression profiles and miRNA-based tools have significant importance in improving the quality of life and longevity of patients.
Review
Oncology
Catherine S. Johnson, Leah M. Cook
Summary: One of the challenges in improving survival of prostate cancer is designing new therapies to target bone metastases. Although regulation of the bone environment has been well characterized, current bone-targeted therapies have limited impact on patient survival, highlighting the complexity of the tumor-bone environment. Chemokine signaling is an important factor in promoting prostate cancer progression in the bone. Understanding and targeting this signaling pathway may provide promising options for treating bone metastasis.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Cinzia Baldessari, Stefania Pipitone, Eleonora Molinaro, Krisida Cerma, Martina Fanelli, Cecilia Nasso, Marco Oltrecolli, Marta Pirola, Elisa D'Agostino, Giuseppe Pugliese, Sara Cerri, Maria Giuseppa Vitale, Bruno Madeo, Massimo Dominici, Roberto Sabbatini
Summary: Bone metastases and bone health are important considerations in the management of prostate cancer patients. This review discusses the biology and clinical implications of bone metastases, as well as current therapeutic strategies. The importance of evaluating bone health and considering specific treatments is emphasized to address the risks associated with both poor bone health and bone metastasis.
Article
Oncology
Mireia Olivan, Marta Garcia, Leticia Suarez, Marc Guiu, Laura Gros, Olga Mendez, Marina Rigau, Jaume Reventos, Miguel F. Segura, Ines de Torres, Jacques Planas, Xavier de la Cruz, Roger R. Gomis, Juan Morote, Ruth Rodriguez-Barrueco, Anna Santamaria
Summary: Around 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, severely affecting patients' quality of life and typically progressing to lethal PCa. Understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. This study provides a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process.
Review
Biochemistry & Molecular Biology
Andy Goebel, Stefania Dell'Endice, Nikolai Jaschke, Sophie Paehlig, Amna Shahid, Lorenz C. Hofbauer, Tilman D. Rachner
Summary: Inflammation plays a critical role in bone metastasis by supporting the survival, migration, invasion, and growth of tumor cells, serving as a key factor in the tumorigenesis and progression of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Lu Yao, Xiangyu Zhang
Summary: Prostate cancer is a common cancer that poses a serious threat with bone metastasis and drug resistance. The theoretical model of cancer stem cells explains the characteristics and challenges of cancer. Targeting cancer stem cells might be more effective in overcoming drug resistance and metastasis.
Article
Oncology
Ivy Chung, Kun Zhou, Courtney Barrows, Jacqueline Banyard, Arianne Wilson, Nathan Rummel, Atsushi Mizokami, Sudipta Basu, Poulomi Sengupta, Badaruddin Shaikh, Shiladitya Sengupta, Diane R. Bielenberg, Bruce R. Zetter
Summary: The study identified specific compounds that showed preferential cytotoxicity and apoptosis towards metastatic prostate cancer cells, suggesting their potential as effective treatment options for this type of cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengmeng Long, Xuemeng Liu, Xu Huang, Min Lu, Xiaomei Wu, Lingyan Weng, Qiuping Chen, Xueting Wang, Li Zhu, Zhongping Chen
Summary: A bone-targeted and hypoxia-responsive polymeric micelle system was developed for effective treatment of bone metastatic prostate cancer, demonstrating significant inhibition of tumor growth in metastatic bone, promotion of osteoblast activity, relief of bone pain, and prolonged survival time.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Qianghua Zhou, Xu Chen, Kai Yao, Yangjie Zhang, Haixia He, Hao Huang, Hao Chen, Shengmeng Peng, Ming Huang, Liang Cheng, Qiang Zhang, Ruihui Xie, Kaiwen Li, Tianxin Lin, Hai Huang
Summary: This study identifies a new regulatory mechanism of STIM1, in which TSPAN18 protects STIM1 from TRIM32-mediated ubiquitination and enhances bone metastasis of PCa by activating the STIM1-Ca2+ signaling axis. This suggests that TSPAN18 may be an attractive therapeutic target for blocking bone metastasis in PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Chuan-Yu Sun, Yuan-Yuan Mi, Sheng-Yang Ge, Qing-Feng Hu, Ke Xu, Yi-Jun Guo, Yi-Fan Tan, Yang Zhang, Fan Zhong, Guo-Wei Xia
Summary: This study explores the biological function of periostin (POSTN) in prostate cancer (PCa) bone metastasis. It is found that inhibiting POSTN can alleviate PCa bone metastasis and there is a positive feedback loop between PCa and osteoblasts mediated by POSTN. POSTN regulates PCa and osteoblast function through integrin receptors. These findings highlight the importance of targeting POSTN as a therapeutic approach for PCa bone metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Zhenjie Wu, Qi Chen, Hooman Djaladat, Andrea Minervini, Robert G. Uzzo, Chandru P. Sundaram, Koon H. Rha, Mark L. Gonzalgo, Reza Mehrazin, Elio Mazzone, Jamil Marcus, Alyssa Danno, James Porter, Aeen Asghar, Fady Ghali, Georgi Guruli, Antoin Douglawi, Giovanni Cacciamani, Alireza Ghoreifi, Giuseppe Simone, Vitaly Margulis, Matteo Ferro, Riccardo Tellini, Andrea Mari, Abhishek Srivastava, James Steward, Ali Al-Qathani, Ahmad Al-Mujalhem, Amit Satish Bhattu, Alexander Mottrie, Firas Abdollah, Daniel D. Eun, Ithaar Derweesh, Alessandro Veccia, Riccardo Autorino, Linhui Wang
Summary: A scoring system based on clinical variables can accurately predict renal insufficiency for cisplatin-based adjuvant chemotherapy after minimally invasive RNU, and it may serve as a tool for patient selection.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Multidisciplinary Sciences
Jeong Woo Yoo, Kyo Chul Koo, Byung Ha Chung, Kwang Suk Lee
Summary: We analyzed the intensity of pain during prostate biopsy and found that adding apex periprostatic nerve block to the base periprostatic nerve block provided better pain control. The anterior sites were more painful than the posterior sites during the magnetic resonance (MRI)-targeted transrectal biopsies.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yeeun Shim, Jongsoo Lee, Jieun Seo, Cheol Keun Park, Saeam Shin, Hyunho Han, Seung-Tae Lee, Jong Rak Choi, Byung Ha Chung, Young Deuk Choi
Summary: This study tested the feasibility of a newly developed platform called whole-genome optical genomic mapping (OGM) for detecting complex genomic rearrangements in prostate cancer (PCa) samples. The results showed that clinically relevant genomic structural variations were successfully detected using OGM. These findings contribute to improving the genetic testing of high-risk PCa.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Jeong Woo Yoo, Kyo Chul Koo, Byung Ha Chung, Sang Yeop Baek, Su Jin Lee, Kyu Hong Park, Kwang Suk Lee
Summary: The study evaluated the diagnostic performance of deep learning artificial intelligence for bladder cancer, demonstrating high accuracy in diagnosis and the ability to distinguish tumor grade based on tumor color.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Abdulghafour Halawani, Kyo Chul Koo, Alex G. Kavanagh, Victor K. F. Wong, Ben H. Chew
Article
Health Care Sciences & Services
Sung-Hoo Hong, Ho Seok Chung, Ill-Young Seo, Tae Gyun Kwon, Hyeon Jeong, Jae-Il Chung, Seung Hyun Jeon, Jae Young Park, Hong Koo Ha, Byung-Ha Chung, Wan Song, Young-Joo Kim, Sang-Hee Kim, Jee-Sun Lee, Juneyoung Lee, Jinsoo Chung
Summary: This study found that effective self-management of adverse events (AEs) associated with targeted therapy can improve treatment duration and patient-reported outcomes (PROs) in advanced renal cell carcinoma (RCC) patients. Repeated education to enhance AE self-management could potentially enhance overall treatment outcomes.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2022)
Article
Urology & Nephrology
Roman Herout, Abdulghafour Halawani, Victor K. F. Wong, Kyo Chul Koo, Tianshuang Zhong, Alina Reicherz, Dirk Lange, Connor M. Forbes, Ben H. Chew
Summary: The purpose of this study is to evaluate the current availability of technology for urolithiasis treatment and ureteroscopy (URS). A survey was conducted among members of the Endourological Society to assess perioperative practice patterns, availability of ureteroscopic technologies, pre- and poststenting practices, and methods to alleviate stent-related symptoms (SRS). The survey revealed urologists' eagerness for the early adoption of novel technologies and adherence to conservative practice patterns focused on patient safety.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Urology & Nephrology
Do Hae Jung, Joo Yong Lee, Dong Hyuk Kang, Kyungtae Ko, Dong Hoon Koh, Ohseong Kwon, Kyo Chul Koo, Kwang Taek Kim, Myung Soo Kim, Bum Soo Kim, Hyeon Woo Kim, Juhyun Park, Woojin Bang, Kyung-Jin Oh, Young Eun Yoon, Ki Soo Lee, Dong Sup Lee, Sang Hyub Lee, Seungsoo Lee, Hun Joo Lee, Wonho Jung, Dae Sung Cho, Sung Yong Cho, Min Soo Choo, Jae Young Choi, Taesoo Choi, Deok Hyun Han, Byoung Kyu Han, Seung Hyun Jeon, Sunghyun Paick, Ill Young Seo, Hyung Joon Kim
Summary: This article provides evidence-based recommendations and expert opinions to help urologists make optimal decisions in managing urolithiasis. Frequently asked questions by urologists in clinical practice are addressed based on the latest evidence and expert opinions. The authors offer practical guidance for the diagnosis, treatment, and prevention of urolithiasis in various clinical scenarios. It serves as a valuable resource for urologists.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Medicine, General & Internal
Tae Jin Kim, Kyo Chul Koo
Summary: This study evaluated the outcomes of microsurgical testicular sperm extraction (mTESE) and identified potential preoperative predictors of sperm retrieval (SR) in patients with non-obstructive azoospermia (NOA). Clinical data of 111 NOA patients who underwent mTESE were reviewed retrospectively. Logistic regression analysis revealed that the T/LH ratio, serum FSH levels, and bilateral testicular volumes were significantly associated with successful sperm extraction.
YONSEI MEDICAL JOURNAL
(2023)
Article
Urology & Nephrology
Dae Ho Kim, Kwang Suk Lee, Kyo Chul Koo, Byung Ha Chung, Jeong Woo Yoo
Summary: This study aimed to investigate the effects of individual anatomical structural variations on micturition symptoms in men with BPH/LUTS. The results showed that decreasing PUA is associated with increased severity of prostate symptoms. Multivariate analysis revealed that age, PUA, and Qmax are correlated with the total international prostate symptom score. Additionally, Qmax is negatively associated with IPP.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Ben H. Chew, Kyo Chul Koo, Abdulghafour Halawani, Colin J. Lundeen, Bodo E. Knudsen, Wilson R. Molina
Summary: This study compared the efficacy of a novel SuperPulsed thulium fiber laser with a commercially available 120 W Ho:YAG laser in stone fragmentation. The results showed that the thulium fiber laser had superior efficacy, with faster stone ablation and smaller particle size.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Gopal Sharma, Milap Shah, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J. Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M. Buffi, Ananthakrishnan Sivaraman, James R. Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Yuvaraja B. Thyavihally, Dipen J. Parekh, Umberto Capitanio, Kris K. Maes, Francesco Porpiglia, Levent Turkeri, Gagan Gautam
Summary: This study aimed to evaluate the perioperative outcomes of robot-assisted partial nephrectomy (RAPN) for patients with complex renal masses. The results suggest that RAPN is a reasonable surgical option for these patients, with acceptable perioperative outcomes.
INDIAN JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Gopal Sharma, Milap Shah, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J. Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M. Buffi, Ananthakrishanan Sivaraman, James R. Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Thyavihally B. Yuvaraja, Dipen J. Parekh, Umberto Capitanio, Kris K. Maes, Francesco Porpiglia, Levent Turkeri, Gagan Gautam
Summary: This study compared perioperative outcomes of robot-assisted partial nephrectomy in patients aged >= 70 years to those age < 70 years. The results showed that the procedure had comparable trifecta outcomes and acceptable perioperative morbidity in selected elderly patients.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Gopal Sharma, Milap Shah, Puneet Ahluwalia, Prokar Dasgupta, Benjamin J. Challacombe, Mahendra Bhandari, Rajesh Ahlawat, Sudhir Rawal, Nicolo M. Buffi, Ananthkrishnan Sivaraman, James R. Porter, Craig Rogers, Alexandre Mottrie, Ronney Abaza, Khoon Ho Rha, Daniel Moon, Thyavihally B. Yuvaraja, Dipen J. Parekh, Umberto Capitanio, Kris K. Maes, Francesco Porpiglia, Levent Turkeri, Gagan Gautam
Summary: This study compared the perioperative outcomes of transperitoneal and retroperitoneal robot-assisted partial nephrectomy. The results showed that retroperitoneal robot-assisted partial nephrectomy had better operative time and warm ischemia time, but higher intraoperative complications, with superior trifecta outcomes.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Alessandro Veccia, Umberto Carbonara, Ithaar Derweesh, Reza Mehrazin, James Porter, Firas Abdollah, Elio Mazzone, Chandru P. Sundaram, Mark Gonzalgo, Riccardo Mastroianni, Alireza Ghoreifi, Giovanni E. Cacciamani, Devin Patel, Jamil Marcus, Alyssa Danno, James Steward, Amit Satish Bhattu, Aeen Asghar, Adam C. Reese, Zhenjie Wu, Robert G. Uzzo, Andrea Minervini, Koon H. Rha, Matteo Ferro, Vitaly Margulis, Lance J. Hampton, Giuseppe Simone, Daniel D. Eun, Hooman Djaladat, Alexandre Mottrie, Riccardo Autorino
Summary: This article describes the surgical steps and outcomes of Xi (R) robotic RNU. The study found that this minimally invasive procedure is reproducible and safe for treating UTUC.
MINERVA UROLOGY AND NEPHROLOGY
(2022)