Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules

Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures

(2011) Jianfeng Xu et al.   BIOTECHNOLOGY ADVANCES

In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli

(2011) Hailin Meng et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Analysis of aggregate size as a process variable affecting paclitaxel accumulation in Taxus suspension cultures

(2011) Martin E. Kolewe et al.   BIOTECHNOLOGY PROGRESS

'Pharmers' hope for first plant drug harvest

(2011) Alisa Opar   NATURE REVIEWS DRUG DISCOVERY

Manipulation of plant metabolic pathways by transcription factors

(2011) Akira Iwase et al.   Plant Biotechnology

Expression and export: recombinant protein production systems for Aspergillus

(2010) André Fleißner et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology

(2010) Regine Eibl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Hyper-production of 13C-labeled trans-resveratrol in Vitis vinifera suspension cell culture by elicitation and in situ adsorption

(2010) Xiangguo Yue et al.   BIOCHEMICAL ENGINEERING JOURNAL

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Biomass production of hairy roots of Artemisia annua and Arachis hypogaea in a scaled-up mist bioreactor

(2010) Ganapathy Sivakumar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Plant-derived vaccines and other therapeutics produced in contained systems

(2010) Rosella Franconi et al.   Expert Review of Vaccines

Transient expression systems for plant-derived biopharmaceuticals

(2010) Tatiana V Komarova et al.   Expert Review of Vaccines

Purification of Plant-Derived Antibodies through Direct Immobilization of Affinity Ligands on Cellulose

(2010) Greg Hussack et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of non-natural flavanones and dihydrochalcones in metabolically engineered yeast

(2010) Sean R. Werner et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Aqueous two-phase systems strategies for the recovery and characterization of biological products from plants

(2010) Oscar Aguilar et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Improved vanillin production in baker's yeast through in silico design

(2010) Ana Brochado et al.   Microbial Cell Factories

Methods and options for the heterologous production of complex natural products

(2010) Haoran Zhang et al.   NATURAL PRODUCT REPORTS

'Biosimilar' drugs poised to penetrate market

(2010) Heidi Ledford   NATURE

Plant natural products from cultured multipotent cells

(2010) Susan Roberts et al.   NATURE BIOTECHNOLOGY

Pfizer stakes a claim in plant cell–made biopharmaceuticals

(2010) Mark Ratner   NATURE BIOTECHNOLOGY

Cultured cambial meristematic cells as a source of plant natural products

(2010) Eun-Kyong Lee et al.   NATURE BIOTECHNOLOGY

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Characterization of aggregate size in Taxus suspension cell culture

(2010) Martin E. Kolewe et al.   PLANT CELL REPORTS

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

(2010) Cui-Ting Wang et al.   PLANT CELL REPORTS

Transcriptome Analysis ofTaxus cuspidataNeedles Based on 454 Pyrosequencing

(2010) Qiong Wu et al.   PLANTA MEDICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Application of an aqueous two-phase systems strategy for the potential recovery of a recombinant protein from alfalfa (Medicago sativa)

(2010) Celeste C. Ibarra-Herrera et al.   SEPARATION AND PURIFICATION TECHNOLOGY

De Novo Biosynthesis of Vanillin in Fission Yeast (Schizosaccharomyces pombe) and Baker's Yeast (Saccharomyces cerevisiae)

(2009) E. H. Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bioprocessing of plant cell cultures for mass production of targeted compounds

(2009) Milen I. Georgiev et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioreactor engineering for recombinant protein production in plant cell suspension cultures

(2009) Ting-Kuo Huang et al.   BIOCHEMICAL ENGINEERING JOURNAL

Foreign protein production using plant cell and organ cultures: Advantages and limitations

(2009) Sharon M.-H. Shih et al.   BIOTECHNOLOGY ADVANCES

Elicitation of silymarin in cell cultures of Silybum marianum: effect of subculture and repeated addition of methyl jasmonate

(2009) Maria Angeles Sánchez-Sampedro et al.   BIOTECHNOLOGY LETTERS

Disposable bioreactors for plant liquid cultures at Litre-scale

(2009) Regine Eibl et al.   ENGINEERING IN LIFE SCIENCES

Continued expression of plant-made vaccines following long-term cryopreservation of antigen-expressing tobacco cell cultures

(2009) Joyce Van Eck et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Advanced separation methods of food anthocyanins, isoflavones and flavanols

(2009) Josep Valls et al.   JOURNAL OF CHROMATOGRAPHY A

Total Synthesis of Vinblastine, Vincristine, Related Natural Products, and Key Structural Analogues

(2009) Hayato Ishikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional genomics for plant natural product biosynthesis

(2009) Keiko Yonekura-Sakakibara et al.   NATURAL PRODUCT REPORTS

Metabolic reprogramming of periwinkle plant culture

(2009) Weerawat Runguphan et al.   Nature Chemical Biology

Sales of biologics to show robust growth through to 2013

(2009) Michael Goodman   NATURE REVIEWS DRUG DISCOVERY

Nature: a vital source of leads for anticancer drug development

(2009) G. M. Cragg et al.   PHYTOCHEMISTRY REVIEWS

Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase

(2009) Grégory Guirimand et al.   PLANT CELL REPORTS

A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation

(2009) David Aviezer et al.   PLoS One

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

(2009) M. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

(2009) Aldwin Anterola et al.   TRANSGENIC RESEARCH

Jasmonate-inducible gene: what does it mean?

(2009) Laurens Pauwels et al.   TRENDS IN PLANT SCIENCE

Statistical elicitor optimization studies for the enhancement of azadirachtin production in bioreactor Azadirachta indica cell cultivation

(2008) Gunjan Prakash et al.   BIOCHEMICAL ENGINEERING JOURNAL

Azadirachtin, a scientific gold mine

(2008) E. David Morgan   BIOORGANIC & MEDICINAL CHEMISTRY

Directing vanillin production from ferulic acid by increased acetyl-CoA consumption in recombinantEscherichia coli

(2008) Eun-Gyeong Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor

(2008) Chunzhao Liu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioreactor strategies for improving production yield and functionality of a recombinant human protein in transgenic tobacco cell cultures

(2008) Ting-Kuo Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Scale-Up of Agrobacterium-Mediated Transient Protein Expression in Bioreactor-Grown Nicotiana glutinosa Plant Cell Suspension Culture

(2008) K.M. O'Neill et al.   BIOTECHNOLOGY PROGRESS

Transcription factors for predictive plant metabolic engineering: are we there yet?

(2008) Erich Grotewold   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Countercurrent Separation of Natural Products#

(2008) Guido F. Pauli et al.   JOURNAL OF NATURAL PRODUCTS

Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine

(2008) Dimitris Platis et al.   JOURNAL OF SEPARATION SCIENCE

Phenotype, diagnosis, and treatment of Gaucher's disease

(2008) Gregory A Grabowski   LANCET

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

(2008) Martin E. Kolewe et al.   MOLECULAR PHARMACEUTICS

Effect of taxol feeding on taxol and related taxane production in Taxus baccata suspension cultures

(2008) Oscar Expósito et al.   New Biotechnology

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY

Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants

(2008) Sally Hassan et al.   PLANT BIOTECHNOLOGY JOURNAL

Preventing unintended proteolysis in plant protein biofactories

(2008) Meriem Benchabane et al.   PLANT BIOTECHNOLOGY JOURNAL

Biosynthesis of plant-derived flavor compounds

(2008) Wilfried Schwab et al.   PLANT JOURNAL

Mapping methyl jasmonate-mediated transcriptional reprogramming of metabolism and cell cycle progression in cultured Arabidopsis cells

(2008) L. Pauwels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and identification of unique marker compounds from the Tasmanian poppy Papaver somniferum N.

(2007) Luke R. Odell et al.   FORENSIC SCIENCE INTERNATIONAL

Flow Cytometric Identification of Paclitaxel-Accumulating Subpopulations

(2005) Michael C. Naill et al.   BIOTECHNOLOGY PROGRESS

Comparison of Transient Protein Expression in Tobacco Leaves and Plant Suspension Culture

(2005) Lauren B. Andrews et al.   BIOTECHNOLOGY PROGRESS