NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice

Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways

(2017) Zhi-na Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury

(2017) Zhi-Na Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Saponins (Ginsenosides) from the Leaves of Panax quinquefolius Ameliorated Acetaminophen-Induced Hepatotoxicity in Mice

(2017) Xing-Yue Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice

(2017) Zi Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ginsenoside Rk1 ameliorates paracetamol-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis

(2017) Jun-Nan Hu et al.   Journal of Ginseng Research

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

Drug-Induced Acute Liver Injury Within 12 Hours After Fluvastatin Therapy

(2016) Li Li et al.   AMERICAN JOURNAL OF THERAPEUTICS

AMP-activated protein kinase and its multifaceted regulation of hepatic metabolism

(2016) Morgan D. Fullerton   CURRENT OPINION IN LIPIDOLOGY

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Nrf2-mediated liver protection by esculentoside A against acetaminophen toxicity through the AMPK/Akt/GSK3β pathway

(2016) Lidong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A platycoside-rich fraction from the root of Platycodon grandiflorum enhances cell death in A549 human lung carcinoma cells via mainly AMPK/mTOR/AKT signal-mediated autophagy induction

(2016) Nam–Hui Yim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Platycodin D exerts anti-tumor efficacy in H22 tumor-bearing mice via improving immune function and inducing apoptosis

(2016) Wei Li et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway

(2015) Tao Zheng et al.   BRITISH JOURNAL OF PHARMACOLOGY

The anti-inflammatory effects of acetaminophen and N-acetylcysteine through suppression of the NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

(2015) Yu Liu et al.   Innate Immunity

Ulinastatin inhibits the inflammation of LPS-induced acute lung injury in mice via regulation of AMPK/NF-κB pathway

(2015) Wuquan Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-κB and the PI3K/Akt Signaling Pathway

(2015) De-Quan Zhang et al.   JOURNAL OF FOOD SCIENCE

Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice

(2015) Wei Li et al.   Food & Function

Verrucarin A enhances TRAIL-induced apoptosis via NF-κB-mediated Fas overexpression

(2013) R.G.P.T. Jayasooriya et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of saponins derived from the roots of Platycodon grandiflorus in lipopolysaccharide-stimulated BV2 microglial cells

(2013) KYUNG-JUN JANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

The innate immune response during liver inflammation and metabolic disease

(2013) Veerle Bieghs et al.   TRENDS IN IMMUNOLOGY

Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis

(2012) Azhar Rasul et al.   APOPTOSIS

Acetylcysteine Therapy for Acetaminophen Poisoning

(2012) Kennon Heard et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

ISOLATION AND PURIFICATION OF SAPONINS FROMPLATYCODON GRANDIFLORUMBY SEMI-PREPARATIVE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY AND LC/ESI-MS

(2012) Wei Li et al.   JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES

Emergency Department Visits for Overdoses of Acetaminophen-Containing Products

(2011) Daniel S. Budnitz et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Intravenous acetylcysteine for the treatment of acetaminophen overdose

(2010) Wendy Klein-Schwartz et al.   EXPERT OPINION ON PHARMACOTHERAPY

Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism

(2010) Smitha V. Bava et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Platycoside N: A New Oleanane-Type Triterpenoid Saponin from the Roots of Platycodon grandiflorum

(2010) Wei Li et al.   MOLECULES

Protective effects of saponins from the root of Platycodon grandiflorum against fatty liver in chronic ethanol feeding via the activation of AMP-dependent protein kinase

(2009) Tilak Khanal et al.   FOOD AND CHEMICAL TOXICOLOGY

Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: Involvement of cytochrome P450 CYP2E1

(2009) Desmond Kwok Po Hau et al.   PHYTOMEDICINE

Roles of Oxidants and Redox Signaling in the Pathogenesis of Acute Respiratory Distress Syndrome

(2008) Sadatomo Tasaka et al.   ANTIOXIDANTS & REDOX SIGNALING

Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice

(2008) Tilak Khanal et al.   FOOD AND CHEMICAL TOXICOLOGY