Naturally occurring chalcones and their biological activities

Molecular Targeted Approaches to Cancer Therapy and Prevention Using Chalcones

(2014) Danielle Jandial et al.   CURRENT CANCER DRUG TARGETS

Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities

(2014) Liyan Yu et al.   FITOTERAPIA

The flavokawains: uprising medicinal chalcones

(2013) Nadiah Abu et al.   Cancer Cell International

Millepachine, a novel chalcone, induces G 2 /M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo

(2013) Wenshuang Wu et al.   CARCINOGENESIS

2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells

(2013) Sun Young Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chalcone derivatives from the fern Cyclosorus parasiticus and their anti-proliferative activity

(2013) Han Wei et al.   FOOD AND CHEMICAL TOXICOLOGY

Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities

(2013) Namki Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages

(2013) Dong-Joo Kwon et al.   FOOD AND CHEMICAL TOXICOLOGY

Salicassin, an Unprecedented ChalconeDiterpene Adduct and a Quinone Methide Triterpenoid fromMaytenus salicifolia

(2013) Cássia G. Magalhães et al.   HELVETICA CHIMICA ACTA

Xanthohumol, a main prenylated chalcone from hops, reduces liver damage and modulates oxidative reaction and apoptosis in hepatitis C virus infected Tupaia belangeri

(2013) Mingbo Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf-2

(2013) Taofeek O. Ajiboye et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Chalcone and Curcumin Derivatives: A Way Ahead for Malarial Treatment

(2013) Dileep Kumar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Novel acetylated chalcone and biflavonoid glycosides fromTrigonosciadium brachytaenium(Boiss.) Alava.

(2013) Malihe Akhavan et al.   NATURAL PRODUCT RESEARCH

Antifungal dimeric chalcone derivative kamalachalcone E fromMallotus philippinensis

(2013) Roshan R. Kulkarni et al.   NATURAL PRODUCT RESEARCH

Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines

(2013) Ivana S. Aljančić et al.   PHYTOCHEMISTRY

Phytochemical investigation of the leaves of Leptoderris fasciculata

(2013) François P. Bi Koffi Kouamé et al.   Phytochemistry Letters

New diprenylated dihyrochalcones from leaves of Artocarpus elasticus

(2013) Faiqah Ramli et al.   Phytochemistry Letters

Antioxidant activity and protection of human umbilical vein endothelial cells from hydrogen peroxide-induced injury by DMC, a chalcone from buds of Cleistocalyx operculatus

(2013) Chun-Lin Ye et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Oxyfadichalcones A–C: three chalcone dimers fused through a cyclobutane ring from Tibetan medicine Oxytropis falcata Bunge

(2013) Xiao-Jing Zhang et al.   TETRAHEDRON

Corrigendum to “Nardokanshone A, a new type of sesquieterpenoid–chalcone hybrid from Nardostachys chinensis” [Tetrahedron Lett. 54 (2013) 4365–4368]

(2013) Peng-Cheng Wang et al.   TETRAHEDRON LETTERS

New chalcone dimers from Caesalpinia ferrea Mart act as potent inhibitors of DNA topoisomerase II

(2013) Susumu Ohira et al.   TETRAHEDRON LETTERS

In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot)

(2012) N.M. Isa et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Synthesis of Biologically Active Chalcones and their Anti-inflammatory Effects

(2012) Jae-Ho Jeon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Exploring Pharmacological Significance of Chalcone Scaffold: A Review

(2012) N. K. Sahu et al.   CURRENT MEDICINAL CHEMISTRY

Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

(2012) Haoyu Ye et al.   FITOTERAPIA

Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein

(2012) Hiroshi Hirata et al.   FOOD CHEMISTRY

Combining the observation of cell morphology with the evaluation of key inflammatory mediators to assess the anti-inflammatory effects of geranyl flavonoid derivatives in breadfruit

(2012) Jer-An Lin et al.   FOOD CHEMISTRY

Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)

(2012) Yasuhiko Izumi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway

(2012) Yuh-Lit Chow et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isobavachalcone suppresses expression of inducible nitric oxide synthase induced by Toll-like receptor agonists

(2012) Hwa-Jeong Shin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolation and identification of antibacterial and cytotoxic compounds from the leaves of Muntingia calabura L.

(2012) Adila S. Sufian et al.   JOURNAL OF ETHNOPHARMACOLOGY

Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease

(2012) Sa Suk Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line

(2012) Ramez N. Eskander et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives

(2012) Syed Nasir Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification

(2012) Oliver A. Battenberg et al.   Molecular BioSystems

Dihydrochalcone glucosides and antioxidant activity from the roots of Anneslea fragrans var. lanceolata

(2012) Hung-Yi Huang et al.   PHYTOCHEMISTRY

Component analysis of propolis collected on Jeju Island, Korea

(2012) Kohsuke Shimomura et al.   PHYTOCHEMISTRY

Flavonoids from Malus hupehensis and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells

(2012) Shu-Qi Wang et al.   PHYTOCHEMISTRY

Geranyl Flavonoid Derivatives from the Fresh Leaves of Artocarpus communis and Their Anti-inflammatory Activity

(2012) Chin-Lin Hsu et al.   PLANTA MEDICA

Potent inhibition of human neutrophil activations by bractelactone, a novel chalcone from Fissistigma bracteolatum

(2012) Yang-Chang Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Potent Antioxidant and Lipoxygenase Inhibitory Flavanone and Chalcone from Erythrina mildbraedii Harms (Fabaceae) of Cameroon

(2012) M. S. Ali et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Boesenbergin A, a chalcone from Boesenbergia rotunda induces apoptosis via mitochondrial dysregulation and cytochrome c release in A549 cells in vitro: Involvement of HSP70 and Bcl2/Bax signalling pathways

(2012) Norbaiti Mohd Isa et al.   Journal of Functional Foods

Bioactive components from the heartwood of Pterocarpus santalinus

(2011) Shou-Fang Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines

(2011) Céline Bruyère et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characteristic of alkylated chalcones from Angelica keiskei on influenza virus neuraminidase inhibition

(2011) Ji-Young Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2′,4′,6′-Tris(methoxymethoxy) chalcone induces apoptosis by enhancing Fas-ligand in activated hepatic stellate cells

(2011) Sung Hee Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Two new chalcone glycosides from the stems of Entada phaseoloides

(2011) Zhong-xiang Zhao et al.   FITOTERAPIA

Dietary chalcones with chemopreventive and chemotherapeutic potential

(2011) Barbora Orlikova et al.   Genes and Nutrition

Extraction, identification and dyeing studies of Isosalipurposide, a natural chalcone dye from Acacia cyanophylla flowers on wool

(2011) H. Ghouila et al.   INDUSTRIAL CROPS AND PRODUCTS

Quick identification of kuraridin, a noncytotoxic anti-MRSA (methicillin-resistant Staphylococcus aureus) agent from Sophora flavescens using high-speed counter-current chromatography

(2011) Ben Chung-Lap Chan et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Flavokawain B inhibits growth of human squamous carcinoma cells: Involvement of apoptosis and cell cycle dysregulation in vitro and in vivo

(2011) Elong Lin et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines

(2011) Toshinori Sakai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Structure of Dihydrochalcones and Related Derivatives and Their Scavenging and Antioxidant Activity against Oxygen and Nitrogen Radical Species

(2011) Alexandre Bentes et al.   MOLECULES

Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis

(2011) Santi Prasad Bajgai et al.   PHYTOCHEMISTRY

Retrodihydrochalcones in Sorghum species: Key intermediates in the biosynthesis of 3-deoxyanthocyanidins?

(2011) Ali Khalil et al.   Phytochemistry Letters

Chalcone synthase and its functions in plant resistance

(2011) T. T. H. Dao et al.   PHYTOCHEMISTRY REVIEWS

Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: Experimental and computational studies

(2011) Rahul B. Birari et al.   PHYTOMEDICINE

Plant derived therapeutics for the treatment of Leishmaniasis

(2011) Rupashree Sen et al.   PHYTOMEDICINE

Preparation of flavonoids and diarylheptanoid from Alpinia katsumadai hayata by microwave-assisted extraction and high-speed counter-current chromatography

(2011) Xiaohua Xiao et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

(2011) Kazuhiro Sugamoto et al.   TETRAHEDRON

In Vitro Antibacterial Activity of Panduratin A against Enterococci Clinical Isolates

(2010) Yaya Rukayadi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of small molecule inhibitors of telomerase activity through transcriptional regulation of hTERT and calcium induction pathway in human lung adenocarcinoma A549 cells

(2010) Yerra Koteswara Rao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression

(2010) Yerra Koteswara Rao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae

(2010) Phi Hung Nguyen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis

(2010) Young Bae Ryu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcone-based inhibitors against hypoxia-inducible factor 1—Structure activity relationship studies

(2010) Balasubramanian Srinivasan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

(2010) Trong Tuan Dao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated fromPiper longumon Melanin Production in B16 Mouse Melanoma Cells

(2010) Osamu OHNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells

(2010) Hui Jing et al.   CANCER LETTERS

Cancer Chemopreventive Activity and Metabolism of Isoliquiritigenin, a Compound Found in Licorice

(2010) M. Cuendet et al.   Cancer Prevention Research

Two new chalcones from Fordia cauliflora

(2010) Zhi Yuan Liang et al.   CHINESE CHEMICAL LETTERS

Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways

(2010) Ping Zhou et al.   FASEB JOURNAL

Two new chalcones from leaves of Morus alba L.

(2010) Yan Yang et al.   FITOTERAPIA

Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cells

(2010) Yu-Feng Kuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer

(2010) Vivek R. Yadav et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isoliquiritigenin Entails Blockade of TGF-β1-SMAD Signaling for Retarding High Glucose-Induced Mesangial Matrix Accumulation

(2010) Jing Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyphenols, Including the New Peapolyphenols A−C, from Pea Root Exudates Stimulate Orobanche foetida Seed Germination

(2010) Antonio Evidente et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antispasmodic and antioxidant activities of fractions and bioactive constituent davidigenin isolated from Mascarenhasia arborescens

(2010) Odile Desire et al.   JOURNAL OF ETHNOPHARMACOLOGY

The flavonoid-rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin-induced glucose-intolerant rats

(2010) Teresa Dias et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

(2010) Ibrahim Jantan et al.   Journal of Natural Medicines

Evelynin, a Cytotoxic Benzoquinone-Typeretro-Dihydrochalcone fromTacca chantrieri

(2010) Jiangnan Peng et al.   JOURNAL OF NATURAL PRODUCTS

C-Methylated Flavonoids fromCleistocalyx operculatusand Their Inhibitory Effects on Novel Influenza A (H1N1) Neuraminidase

(2010) Trong-Tuan Dao et al.   JOURNAL OF NATURAL PRODUCTS

Antibacterial and Synergistic Activity of Prenylated Chalcone Isolated from the Roots of Sophora flavescens

(2010) Guem-San Lee   Journal of the Korean Society for Applied Biological Chemistry

Polyphenols Displaying Tyrosinase Inhibition from the Seed of Psoralea corylifolia

(2010) Jun Young Kim   Journal of the Korean Society for Applied Biological Chemistry

Naringenin chalcone improves adipocyte functions by enhancing adiponectin production

(2010) Taro Horiba et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells

(2010) Ik-Soo Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Two New Quinochalcones from the Florets ofCarthamus tinctorius

(2010) Jian-Shuang Jiang et al.   ORGANIC LETTERS

Medicinal plants

(2010) V. N. Syrov et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Phloridzin: Biosynthesis, distribution and physiological relevance in plants

(2010) Christian Gosch et al.   PHYTOCHEMISTRY

Chalcone glycosides from aerial parts of Brassica rapa L. ‘hidabeni’, turnip

(2010) Masayuki Ninomiya et al.   Phytochemistry Letters

Antimicrobial, antiviral and cytotoxic activity of extracts and constituents from Polygonum spectabile Mart.

(2010) Geraldo Célio Brandão et al.   PHYTOMEDICINE

Natural Compounds with Aromatase Inhibitory Activity: An Update

(2010) Marcy Balunas et al.   PLANTA MEDICA

Bio-guided isolation of potential antimicrobial and antioxidant agents from the stem bark of Trilepisium madagascariense

(2010) G.N. Teke et al.   SOUTH AFRICAN JOURNAL OF BOTANY

A single chalcone and additional rotenoids from Lonchocarpus nicou

(2010) Martin A. Lawson et al.   TETRAHEDRON LETTERS

Naringenin Chalcone Suppresses Allergic Asthma by Inhibiting the Type-2 Function of CD4 T Cells

(2010) Chiaki Iwamura et al.   ALLERGOLOGY INTERNATIONAL

Inhibitory Effect of 2,4,2′,4′-Tetrahydroxy-3-(3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis

(2009) Xiaodong Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cytoprotective Constituents of the Heartwood of Caesalpinia sappan on Glutamate-Induced Oxidative Damage in HT22 Cells

(2009) Gil-Saeng Jeong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity

(2009) Anastasia Detsi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chalcones Enhance TRAIL-Induced Apoptosis in Prostate Cancer Cells

(2009) Ewelina Szliszka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-inflammatory Activity of Flavokawain B from Alpinia pricei Hayata

(2009) Chien-Tsong Lin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In Vitro Hepatic Biotransformation of Aspalathin and Nothofagin, Dihydrochalcones of Rooibos (Aspalathus linearis), and Assessment of Metabolite Antioxidant Activity

(2009) J. Debora van der Merwe et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

(2009) Subhash Padhye et al.   Journal of Hematology & Oncology

Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: A molecular docking analysis

(2009) Caitlin E. Cassidy et al.   JOURNAL OF MOLECULAR MODELING

Phenolic compounds from Cryptocarya konishii: their cytotoxic and tyrosine kinase inhibitory properties

(2009) Fera Kurniadewi et al.   Journal of Natural Medicines

Dihydrochalcones: Implication in resistance to oxidative stress and bioactivities against advanced glycation end-products and vasoconstriction

(2009) Thomas Dugé de Bernonville et al.   PHYTOCHEMISTRY

Antiplasmodial β-hydroxydihydrochalcone from seedpods of Tephrosia elata

(2009) Lois M. Muiva et al.   Phytochemistry Letters

Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.

(2009) Prabhjit Kaur et al.   TOXICOLOGY IN VITRO

Isoliquiritigenin 2′-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1

(2009) Young-Man Lee et al.   TOXICOLOGY IN VITRO

Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts

(2008) Soon Nam Kim et al.   CELL BIOLOGY INTERNATIONAL

Isoliquiritigenin induces monocytic differentiation of HL-60 cells

(2008) Defang Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

C-Geranylated Chalcones from the Stems ofAngelicakeiskeiwith Superoxide-Scavenging Activity

(2008) Nobuwa Aoki et al.   JOURNAL OF NATURAL PRODUCTS

A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T Cells

(2008) Tomoaki Kahyo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Antiangiogenic effects of flavonoids and chalcones

(2008) J MOJZIS et al.   PHARMACOLOGICAL RESEARCH

Flavonoids and terpenoids from Helichrysum forskahlii

(2008) Adnan J. Al-Rehaily et al.   PHYTOCHEMISTRY

Isoprenylated flavonoids from the roots of Sophora tonkinensis

(2008) Xing-Nuo Li et al.   Phytochemistry Letters

Influence of chalcone analogues on serum glucose levels in hyperglycemic rats

(2007) Elga Heloísa Alberton et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (Wax Jambu)

(2007) Mario J. Simirgiotis et al.   FOOD CHEMISTRY

Tyrosinase inhibitors from paper mulberry (Broussonetia papyrifera)

(2007) Zong-Ping Zheng et al.   FOOD CHEMISTRY