Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
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Title
Flavonoid compounds as reversal agents of the P-glycoprotein-mediated multidrug resistance: biology, chemistry and pharmacology
Authors
Keywords
Flavonoids, P-glycoprotein inhibition, Drug efflux, Multidrug resistance
Journal
PHYTOCHEMISTRY REVIEWS
Volume 14, Issue 2, Pages 233-272
Publisher
Springer Nature
Online
2014-04-27
DOI
10.1007/s11101-014-9358-0
References
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Note: Only part of the references are listed.- Emerging Significance of Flavonoids as P-Glycoprotein Inhibitors in Cancer Chemotherapy
- (2016) Tripta Bansal et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
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- (2014) Young-Ah Cho et al. Pharmacological Reports
- Flavonoids from Fruit and Vegetables: A Focus on Cardiovascular Risk Factors
- (2013) J. Y. Toh et al. Current Atherosclerosis Reports
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- (2013) Jing Yang et al. JOURNAL OF ETHNOPHARMACOLOGY
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- (2013) Toshiaki Makino et al. Journal of Natural Medicines
- Structure-Activity Analysis of Flavonoids: Direct and Indirect Antioxidant, and Antiinflammatory Potencies and Toxicities
- (2013) Petra A. Tsuji et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Novel Insights into the Pharmacology of Flavonoids
- (2013) Barbara Romano et al. PHYTOTHERAPY RESEARCH
- Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest
- (2013) Litao Zhu et al. TOXICOLOGY LETTERS
- Phytochemical composition and in vitro antioxidant activity of aqueous extract of Aerva lanata (L.) Juss. ex Schult. Stem (Amaranthaceae)
- (2013) Gaurav Kumar et al. Asian Pacific Journal of Tropical Medicine
- Flavonoid Bioavailability and Attempts for Bioavailability Enhancement
- (2013) Surangi Thilakarathna et al. Nutrients
- New Insight into P-Glycoprotein as a Drug Target
- (2012) Albert Breier et al. Anti-Cancer Agents in Medicinal Chemistry
- Comparative evaluation of the teratogenicity of genistein and genistin using rat whole embryo culture and limbud micromass culture methods
- (2012) Peng Zou et al. FOOD AND CHEMICAL TOXICOLOGY
- Phytotoxic Effect, Uptake, and Transformation of Biochanin A in Selected Weed Species
- (2012) Md. Tariqul Islam Shajib et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects
- (2012) Angel Josabad Alonso-Castro et al. JOURNAL OF ETHNOPHARMACOLOGY
- In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent
- (2012) In Kei Lam et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea
- (2012) Guang-Jian Du et al. Nutrients
- The transport of antiepileptic drugs by P-glycoprotein
- (2011) Chunbo Zhang et al. ADVANCED DRUG DELIVERY REVIEWS
- Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport
- (2011) Heidrun Potschka ADVANCED DRUG DELIVERY REVIEWS
- Effects of baicalein on the pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats: Possible role of cytochrome p450 3A4 and P-glycoprotein inhibition by baicalein
- (2011) Cheng Li et al. ARCHIVES OF PHARMACAL RESEARCH
- Effects of morin on the pharmacokinetics of docetaxel in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors
- (2011) Si H. Yang et al. ARCHIVES OF PHARMACAL RESEARCH
- Effects of myricetin on the bioavailability of doxorubicin for oral drug delivery in Rats: Possible role of CYP3A4 and P-glycoprotein inhibition by myricetin
- (2011) Sang-Joon Choi et al. ARCHIVES OF PHARMACAL RESEARCH
- Effects of quercetin on the bioavailability of doxorubicin in rats: Role of CYP3A4 and P-gp inhibition by quercetin
- (2011) Jun-Shik Choi et al. ARCHIVES OF PHARMACAL RESEARCH
- Flavonoids as inhibitors of human CD38
- (2011) Esther Kellenberger et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New Uses for Old Drugs: Pharmacophore-Based Screening for the Discovery of P-Glycoprotein Inhibitors
- (2011) Andreia Palmeira et al. Chemical Biology & Drug Design
- ABC Multidrug Transporters: Target for Modulation of Drug Pharmacokinetics and Drug-Drug Interactions
- (2011) Beatrice Marquez et al. CURRENT DRUG TARGETS
- Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats
- (2011) Joon Hee Park et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2011) Anna Jäger et al. MOLECULES
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- (2011) Van Tran et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
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- (2011) Sheelendra Pratap Singh et al. PHYTOTHERAPY RESEARCH
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- (2011) AR Tapas et al. TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
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- (2010) Jiye Zhang et al. BIOMEDICAL CHROMATOGRAPHY
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- (2010) Ming-Thau Sheu et al. CHEMICAL & PHARMACEUTICAL BULLETIN
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- (2010) H. Sugimoto et al. DRUG METABOLISM AND DISPOSITION
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- (2009) Guang-Xiong Zhou et al. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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- (2009) Woon Jung Go et al. JOURNAL OF NATURAL PRODUCTS
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- (2009) Ana I. Alvarez et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2009) Takuya Matsui et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Dietary phenolics: chemistry, bioavailability and effects on health
- (2009) Alan Crozier et al. NATURAL PRODUCT REPORTS
- Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy
- (2009) G. Corea et al. PHYTOCHEMISTRY REVIEWS
- Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin
- (2008) Jun-Shik Choi et al. ARCHIVES OF PHARMACAL RESEARCH
- Enhanced bioavailability of verapamil after oral administration with hesperidin in rats
- (2008) Yong-Ji Piao et al. ARCHIVES OF PHARMACAL RESEARCH
- Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to rats
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- In vitro–in vivo correlation in p-glycoprotein mediated transport in intestinal absorption
- (2008) Eva M. del Amo et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- The neuroprotective potential of flavonoids: a multiplicity of effects
- (2008) David Vauzour et al. Genes and Nutrition
- Effect of Grapefruit Juice, Naringin, Naringenin, and Bergamottin on the Intestinal Carrier-Mediated Transport of Talinolol in Rats
- (2008) Whocely Victor de Castro et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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- (2008) Yong-Ji Piao et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
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- (2008) Tripta Bansal et al. LIFE SCIENCES
- Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy
- (2008) D. S. Miller et al. PHARMACOLOGICAL REVIEWS
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- (2008) Santosh K. Katiyar et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
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- (2008) Kenjiro Toki et al. PHYTOCHEMISTRY
- Pachypodol, a flavonol from the leaves ofCalycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell linein vitro
- (2008) Husne-Ara Ali et al. PHYTOTHERAPY RESEARCH
- A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs
- (2007) Kristian Linnet et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
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