Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation

(2010) Pieter Rondou et al.   CELLULAR SIGNALLING

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

(2010) Kathryn A. DeFea   CELLULAR SIGNALLING

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

(2010) Michelle L Halls et al.   EMBO JOURNAL

Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats

(2010) Qi Xu et al.   HYPERTENSION

The Epstein-Barr Virus-encoded G Protein-coupled Receptor BILF1 Hetero-oligomerizes with Human CXCR4, Scavenges GαiProteins, and Constitutively Impairs CXCR4 Functioning

(2010) Saskia Nijmeijer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP79/150 Interacts with AC8 and Regulates Ca2+-dependent cAMP Synthesis in Pancreatic and Neuronal Systems

(2010) Debbie Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Positive Inotropic Effect of Relaxin-2 in Human Atrial Myocardium is Preserved in End-Stage Heart Failure: Role of Gi-Phosphoinositide-3 Kinase Signaling

(2010) Thomas Dschietzig et al.   JOURNAL OF CARDIAC FAILURE

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

(2010) Guillaume Pidoux et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

The G-protein Coupled Receptor Associated Sorting Protein GASP-1 Regulates the Signalling and Trafficking of the Viral Chemokine Receptor US28

(2010) Pia Tschische et al.   TRAFFIC

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases

(2010) M. L. Halls et al.   Cold Spring Harbor Perspectives in Biology

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

(2009) Gabrielle E. Callander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells

(2009) Michelle L. Halls et al.   Annals of the New York Academy of Sciences

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

(2009) Anneleen Spooren et al.   CELLULAR SIGNALLING

Intravenous Recombinant Human Relaxin in Compensated Heart Failure: A Safety, Tolerability, and Pharmacodynamic Trial

(2009) Thomas Dschietzig et al.   JOURNAL OF CARDIAC FAILURE

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

The Constitutively Active V2 Receptor Mutants Conferring NSIAD Are Weakly Sensitive to Agonist and Antagonist Regulation

(2009) Julie Tenenbaum et al.   PLoS One

Autoregulation of human relaxin-2 gene expression critically involves relaxin and glucocorticoid receptor binding to glucocorticoid response half-sites in the relaxin-2 promoter

(2009) Thomas Dschietzig et al.   REGULATORY PEPTIDES

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells

(2008) András Kern et al.   ENDOCRINOLOGY

Relaxin Family Peptide Receptor-1 Protects against Airway Fibrosis during Homeostasis But Not against Fibrosis Associated with Chronic Allergic Airways Disease

(2008) Chrishan S. Samuel et al.   ENDOCRINOLOGY

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

(2008) Angela Manegold Svendsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Relaxin signalling in primary cultures of human myometrial cells

(2008) K. Heng et al.   MOLECULAR HUMAN REPRODUCTION

Relaxin Family Peptide Receptor (RXFP1) Coupling to G i3 Involves the C-Terminal Arg752 and Localization within Membrane Raft Microdomains

(2008) M. L. Halls et al.   MOLECULAR PHARMACOLOGY

Physiological Roles for G Protein-Regulated Adenylyl Cyclase Isoforms: Insights from Knockout and Overexpression Studies

(2008) Rachna Sadana et al.   NEUROSIGNALS

RXFP1-inactive relaxin activates human glucocorticoid receptor: Further investigations into the relaxin–GR pathway

(2008) Thomas Dschietzig et al.   REGULATORY PEPTIDES

Location, location, location…site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

(2008) Andrew B. Tobin et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cloning, Expression, and Functional Characterization of Relaxin Receptor (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 7) Splice Variants from Human Fetal Membranes

(2007) András Kern et al.   ENDOCRINOLOGY

Cooperative Binding of Insulin-Like Peptide 3 to a Dimeric Relaxin Family Peptide Receptor 2

(2007) Angela Manegold Svendsen et al.   ENDOCRINOLOGY