Inhibition and Termination of Physiological Responses by GTPase Activating Proteins

Neurofibromin 1 (NF1) Defects Are Common in Human Ovarian Serous Carcinomas and Co-occur with TP53 Mutations

(2015) Navneet Sangha et al.   NEOPLASIA

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

The Ras-ERK pathway: Understanding site-specific signaling provides hope of new anti-tumor therapies

(2010) Fernando Calvo et al.   BIOESSAYS

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

(2010) Shehab A. Ismail et al.   CELL

Rab protein evolution and the history of the eukaryotic endomembrane system

(2010) Andrew Brighouse et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Gαq allosterically activates and relieves autoinhibition of p63RhoGEF

(2010) Aruna Shankaranarayanan et al.   CELLULAR SIGNALLING

Rap1, a mercenary among the Ras-like GTPases

(2010) E.W. Frische et al.   DEVELOPMENTAL BIOLOGY

Unravelling the mechanism of dual-specificity GAPs

(2010) Begoña Sot et al.   EMBO JOURNAL

p63RhoGEF—a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells

(2010) Christina M. Wuertz et al.   FASEB JOURNAL

Neutrophil Functions and Autoimmune Arthritis in the Absence of p190RhoGAP: Generation and Analysis of a Novel Null Mutation in Mice

(2010) T. Nemeth et al.   JOURNAL OF IMMUNOLOGY

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

(2010) Jordi Barretina et al.   NATURE GENETICS

An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB

(2010) Junxia Min et al.   NATURE MEDICINE

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Linking actin dynamics and gene transcription to drive cellular motile functions

(2010) Eric N. Olson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins

(2010) Xiaojing Ye et al.   NEURON

Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation

(2010) P J Mishra et al.   ONCOGENE

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3-DH domain linker

(2010) Carsten Kintscher et al.   PROTEIN SCIENCE

Rho and Ras GTPases in Axon Growth, Guidance, and Branching

(2010) A. Hall et al.   Cold Spring Harbor Perspectives in Biology

The N-terminal RASSF family: a new group of Ras-association-domaincontaining proteins, with emerging links to cancer formation

(2009) Victoria Sherwood et al.   BIOCHEMICAL JOURNAL

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of the Substrate Preference of p190RhoGAP by Protein Kinase C-Mediated Phosphorylation of a Phospholipid Binding Site

(2009) Magdolna Lévay et al.   BIOCHEMISTRY

Rho GTPases in hematopoiesis and hemopathies

(2009) J. C. Mulloy et al.   BLOOD

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling

(2009) K. Szczur et al.   BLOOD

ADAM-mediated amphiregulin shedding and EGFR transactivation

(2009) S. Kasina et al.   CELL PROLIFERATION

The Rho-Linked Mental Retardation Protein OPHN1 Controls Synaptic Vesicle Endocytosis via Endophilin A1

(2009) Akiko Nakano-Kobayashi et al.   CURRENT BIOLOGY

Control of cell adhesion dynamics by Rap1 signaling

(2009) Benjamin Boettner et al.   CURRENT OPINION IN CELL BIOLOGY

The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors

(2009) N. Nadif Kasri et al.   GENES & DEVELOPMENT

New Insights into How the Rho Guanine Nucleotide Dissociation Inhibitor Regulates the Interaction of Cdc42 with Membranes

(2009) Jared L. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T Cell Receptor-dependent Tyrosine Phosphorylation of β2-Chimaerin Modulates Its Rac-GAP Function in T Cells

(2009) María Siliceo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation

(2009) Grantley R. Peck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yersinia enterocolitica differentially modulates RhoG activity in host cells

(2009) B. Roppenser et al.   JOURNAL OF CELL SCIENCE

Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses

(2009) J. M. Cunnick et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

(2009) M. Aittaleb et al.   MOLECULAR PHARMACOLOGY

A score for membrane fusion

(2009) Ruth N. Collins et al.   NATURE

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

New roles for endosomes: from vesicular carriers to multi-purpose platforms

(2009) Gwyn W. Gould et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Improved Insulin Sensitivity After Exercise: Focus on Insulin Signaling

(2009) Christian Frøsig et al.   Obesity

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia

(2009) S. Dash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPase function in Golgi trafficking

(2009) Francis A. Barr   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

(2008) Shuhei Ishikura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rab10 in insulin-stimulated GLUT4 translocation

(2008) Hiroyuki Sano et al.   BIOCHEMICAL JOURNAL

A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

(2008) Alexander Eberth et al.   BIOCHEMICAL JOURNAL

P120-Ras GTPase activating protein (RasGAP): A multi-interacting protein in downstream signaling

(2008) Perayot Pamonsinlapatham et al.   BIOCHIMIE

Rab and Arl GTPase Family Members Cooperate in the Localization of the Golgin GCC185

(2008) Alondra Schweizer Burguete et al.   CELL

Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

(2008) Yijun Cui et al.   CELL

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling

(2008) María José Caloca et al.   CELLULAR SIGNALLING

Coordination of Rho and Rac GTPase Function via p190B RhoGAP

(2008) Rodrigo I. Bustos et al.   CURRENT BIOLOGY

Coordinating Speed and Amplitude in G-Protein Signaling

(2008) Elliott M. Ross   CURRENT BIOLOGY

Function and regulation of local axonal translation

(2008) Andrew C Lin et al.   CURRENT OPINION IN NEUROBIOLOGY

The Rap–RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues

(2008) Andrea Scrima et al.   EMBO JOURNAL

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

(2008) Vladimir Pena et al.   EMBO REPORTS

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Decreased Expression of the RAS-GTPase Activating Protein RASAL1 Is Associated With Colorectal Tumor Progression

(2008) Miki Ohta et al.   GASTROENTEROLOGY

Type III Secretion Decreases Bacterial and Host Survival following Phagocytosis of Yersinia pseudotuberculosis by Macrophages

(2008) Y. Zhang et al.   INFECTION AND IMMUNITY

Identification of an Autoinhibitory Mechanism That Restricts C1 Domain-mediated Activation of the Rac-GAP α2-Chimaerin

(2008) Francheska Colón-González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation

(2008) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of Arf GTPase-activating Protein Activity by the BAR Domain in ASAP1

(2008) Xiaoying Jian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consensus nomenclature for the human ArfGAP domain-containing proteins

(2008) Richard A. Kahn et al.   JOURNAL OF CELL BIOLOGY

p190RhoGAP is the convergence point of adhesion signals from α5β1integrin and syndecan-4

(2008) Mark D. Bass et al.   JOURNAL OF CELL BIOLOGY

Phospholipase C isozymes as effectors of Ras superfamily GTPases

(2008) T. Kendall Harden et al.   JOURNAL OF LIPID RESEARCH

Neurofibromin Is Required for Barrel Formation in the Mouse Somatosensory Cortex

(2008) M. E. Lush et al.   JOURNAL OF NEUROSCIENCE

Reduced phosphorylation of AS160 contributes to glucocorticoid-mediated inhibition of glucose uptake in human and murine adipocytes

(2008) Sherry Ngo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of Glucose Transporter 4 Translocation by the Rab Guanosine Triphosphatase-Activating Protein AS160/TBC1D4: Role of Phosphorylation and Membrane Association

(2008) Jacqueline Stöckli et al.   MOLECULAR ENDOCRINOLOGY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Human CHN1 Mutations Hyperactivate  2-Chimaerin and Cause Duane's Retraction Syndrome

(2008) N. Miyake et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Regulation of actin cytoskeleton dynamics by Arf-family GTPases

(2008) Kenneth R. Myers et al.   TRENDS IN CELL BIOLOGY

The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway

(2007) Marie Dance et al.   CELLULAR SIGNALLING

Diverse roles of Rho family GTPases in neuronal development, survival, and death

(2007) Daniel et al.   Frontiers in Bioscience-Landmark

Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver

(2007) Yi-Chun Liao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

(2007) Kevin D. Healy et al.   MOLECULAR CARCINOGENESIS