Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivotumor growth

(2010) Pedro Andreu-Pérez et al.   BMC CANCER

Lack of association between LOH in the 9p region and clinicopathologic parameters in primary breast cancer

(2010) Sarah Franco Vieira de Oliveira et al.   CANCER GENETICS AND CYTOGENETICS

Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma

(2009) Y. Kadariya et al.   CANCER RESEARCH

Homozygous Deletion of MTAP Gene as a Poor Prognosticator in Gastrointestinal Stromal Tumors

(2009) H.-Y. Huang et al.   CLINICAL CANCER RESEARCH

Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma

(2009) Josh Sommer et al.   JOURNAL OF PATHOLOGY

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells

(2009) T. W. H. Li et al.   MOLECULAR PHARMACOLOGY

EGFR Mutations are More Frequent in Well-Differentiated than in Poor-Differentiated Lung Adenocarcinomas

(2009) Yan Liu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy

(2009) Martin Lubin et al.   PLoS One

A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer

(2008) Hedy Lee Kindler et al.   INVESTIGATIONAL NEW DRUGS

Immunohistochemical diagnosis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma

(2008) Fumiaki Watanabe et al.   LUNG CANCER