The WNKs: Atypical Protein Kinases With Pleiotropic Actions

High angiotensin II state without cardiac remodeling (Bartter’s and Gitelman’s syndromes): Are angiotensin II type 2 receptors involved?

(2014) L. A. Calò et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Growth effects of insulin and insulin analogues

(2011) Juergen Sandow   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney

(2010) Gulibaha Talati et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WNK4 Kinase Stimulates Caveola-mediated Endocytosis of TRPV5 Amplifying the Dynamic Range of Regulation of the Channel by Protein Kinase C

(2010) Seung-Kuy Cha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study

(2010) Sandosh Padmanabhan et al.   JOURNAL OF HYPERTENSION

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

(2010) J. Hadchouel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial-Specific Expression of WNK1 Kinase Is Essential for Angiogenesis and Heart Development in Mice

(2009) Jian Xie et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium

(2009) Sung Huhn Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RANK/RANKL: Regulators of Immune Responses and Bone Physiology

(2009) Andreas Leibbrandt et al.   Annals of the New York Academy of Sciences

Kinetic Mechanism and Inhibitor Characterization of WNK1 Kinase

(2009) Yukiko I. Yagi et al.   BIOCHEMISTRY

Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation

(2009) A. Rotthier et al.   BRAIN

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Autism-associated familial microdeletion of Xp11.22

(2009) Y Qiao et al.   CLINICAL GENETICS

Advances in meningioma therapy

(2009) Andrew D. Norden et al.   Current Neurology and Neuroscience Reports

TRP Channels and Pain

(2009) Daniel Cortright et al.   CURRENT PHARMACEUTICAL DESIGN

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure

(2009) Akihito Ohta et al.   HUMAN MOLECULAR GENETICS

Role of V-ATPases in solid tumors: Importance of the subunit C (Review)

(2009) Pérez-Sayáns   INTERNATIONAL JOURNAL OF ONCOLOGY

The Ca2+Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate

(2009) Anand Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ROMK Channel and K+Homeostasis by Kidney-specific WNK1 Kinase

(2009) Zhen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNK4 Diverts the Thiazide-sensitive NaCl Cotransporter to the Lysosome and Stimulates AP-3 Interaction

(2009) Arohan R. Subramanya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LINGO-1 Interacts with WNK1 to Regulate Nogo-induced Inhibition of Neurite Extension

(2009) Zhaohuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

(2009) David J. Rozansky et al.   JOURNAL OF CLINICAL INVESTIGATION

Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination

(2009) Yuko Osada et al.   JOURNAL OF HUMAN GENETICS

Carriers of Recessive WNK1/HSN2 Mutations for Hereditary Sensory and Autonomic Neuropathy Type 2 (HSAN2) Are More Sensitive to Thermal Stimuli

(2009) M. L. Loggia et al.   JOURNAL OF NEUROSCIENCE

Association of Ala589Ser polymorphism of WNK4 gene with essential hypertension in a high-risk Chinese population

(2009) Zhi-Jun Sun et al.   Journal of Physiological Sciences

Renal and Brain Isoforms of WNK3 Have Opposite Effects on NCCT Expression

(2009) M. Glover et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway

(2009) B. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-κB-mediated induction of XIAP, cIAP2, BCL-XL and survivin

(2009) Majid Momeny et al.   MEDICAL ONCOLOGY

Immune changes in post-menopausal osteoporosis: the Immunos study

(2009) V. Breuil et al.   OSTEOPOROSIS INTERNATIONAL

Mechanosensitive TRP channels in cardiovascular pathophysiology

(2009) Ryuji Inoue et al.   PHARMACOLOGY & THERAPEUTICS

Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion

(2009) Stephen Newhouse et al.   PLoS One

Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels

(2009) P. Yue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

(2009) P. San-Cristobal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

(2009) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmins bind calcium to release insulin

(2008) Benoit R. Gauthier et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Function, structure and regulation of the vacuolar (H+)-ATPases

(2008) Kevin C. Jefferies et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

What is the role of arsenic in newly diagnosed APL?

(2008) Martin S. Tallman   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane

(2008) Yi Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK

(2008) Meena Murthy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells

(2008) Eric Delpire et al.   BIOCHEMICAL JOURNAL

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

(2008) M. A. Sanz et al.   BLOOD

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

WNK2 modulates MEK1 activity through the Rho GTPase pathway

(2008) Sónia Moniz et al.   CELLULAR SIGNALLING

Hereditary breast cancer: from bench to bedside

(2008) Jacques De Grève et al.   CURRENT OPINION IN ONCOLOGY

Conditional Transgenic Mice for Studying the Role of the Glucocorticoid Receptor in the Renal Collecting Duct

(2008) Aurélie Nguyen Dinh Cat et al.   ENDOCRINOLOGY

Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF

(2008) Miriam Shaharabany et al.   FEBS Journal

The SH3 domain- a family of versatile peptide- and protein-recognition module

(2008) Tomonori Kaneko   Frontiers in Bioscience-Landmark

Common Variation in the WNK1 Gene and Blood Pressure in Childhood

(2008) Martin D. Tobin et al.   HYPERTENSION

Deletion of WNK1 First Intron Results in Misregulation of Both Isoforms in Renal and Extrarenal Tissues

(2008) Céline Delaloy et al.   HYPERTENSION

Trends in Hypertension Prevalence, Awareness, Treatment, and Control Rates in United States Adults Between 1988–1994 and 1999–2004

(2008) Jeffrey A. Cutler et al.   HYPERTENSION

Upregulation of human with-no-lysine kinase-4 gene expression by GATA-1 acetylation

(2008) Miao Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of a Third Conserved Phosphorylation Site in SGK1

(2008) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Genome-Wide Expression Study on Human Circulating B Cells Suggests a Novel ESR1 and MAPK3 Network for Postmenopausal Osteoporosis

(2008) Peng Xiao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

(2008) Motoko Chiga et al.   KIDNEY INTERNATIONAL

Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific

(2008) Peter Jun et al.   NEURO-ONCOLOGY

Gitelman syndrome

(2008) Nine V.A.M. Knoers et al.   Orphanet Journal of Rare Diseases

The plant WNK gene family and regulation of flowering time inArabidopsis

(2008) Y. Wang et al.   PLANT BIOLOGY

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

(2008) J. Ponce-Coria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Holding Their Own: The Noncanonical Roles of Smad Proteins

(2008) L. L. Hoover et al.   Science Signaling

Aldosterone-induced signalling and cation transport in the distal nephron

(2008) W THOMAS et al.   STEROIDS