Article
Multidisciplinary Sciences
Wenfei Sun, Hua Dong, Christian Wolfrum
Summary: The study reveals that local acetate directly inhibits brown adipose tissue thermogenesis, decreases energy expenditure, and down-regulates genes related to the tricarboxylic acid cycle and brown adipocyte formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Liqing Zang, Yasuhito Shimada, Hiroko Nakayama, Hirotaka Katsuzaki, Youngil Kim, Djong-Chi Chu, Lekh Raj Juneja, Junya Kuroyanagi, Norihiro Nishimura
Summary: Green tea extract (GTE) has been demonstrated to have significant effects in attenuating obesity development, as shown by decreased visceral adipose tissue accumulation in juvenile zebrafish and improved visceral adiposity and plasma triglyceride levels in adult zebrafish. RNA sequencing analysis revealed that GTE affects pathways associated with anti-obesity regulation, suggesting its potential as a preventive agent against obesity.
Review
Nutrition & Dietetics
Natalia Santillana, Camila Astudillo-Guerrero, Amanda D'Espessailles, Gonzalo Cruz
Summary: White adipose tissue dysfunction is crucial in the pathogenesis of cardiometabolic alterations related to obesity. Dysfunction is characterized by limited expansion capacity, increased adipocyte hypertrophy, altered adipokine secretion, macrophage accumulation and inflammation. Simple tools are needed to identify individuals with dysfunctional adipose tissue who are at risk of developing metabolic alterations. This review highlights the current pathophysiological mechanisms and emerging measurements for assessing white adipose tissue functionality.
Article
Cell Biology
Ganbin Li, Haoyu Zhang, Ke Cao, Zhiwei Zhai, Zhenjun Wang, Lei Yang, Jiagang Han
Summary: This study used whole transcriptome RNA sequencing to analyze the differential expression of noncoding RNA (ncRNA) and mRNA in visceral adipose tissue from obese and lean individuals. The results revealed the involvement of ncRNAs in inflammation-related pathways and identified an obesity-associated competing endogenous RNA (ceRNA) network regulated by circORC5 and circNTRK2.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Michele Moruzzi, Nora Kloeting, Matthias Blueher, Ilenia Martinelli, Seyed Khosrow Tayebati, Maria Gabriella Gabrielli, Proshanta Roy, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Giulio Lupidi, Francesco Amenta, Daniele Tomassoni
Summary: Although tart cherries are rich in anthocyanins, the study found that a tart cherry-enriched diet did not alter the accumulation of visceral fat, but could decrease inflammatory markers in adipose tissue.
Article
Biotechnology & Applied Microbiology
Lars E. Borm, Alejandro Mossi Albiach, Camiel C. A. Mannens, Jokubas Janusauskas, Ceren Ozgun, David Fernandez-Garcia, Rebecca Hodge, Francisca Castillo, Charlotte R. H. Hedin, Eduardo J. Villablanca, Per Uhlen, Ed S. Lein, Simone Codeluppi, Sten Linnarsson
Summary: EEL FISH is a method that allows for rapid processing of large tissue samples while maintaining high resolution. By electrophoretically transferring RNA, EEL speeds up data acquisition and preserves single-cell resolution, enabling the study of spatial transcriptomes in the mouse brain and the human visual cortex.
NATURE BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Genetics & Heredity
Gabriel Wagner, Anna Fenzl, Josefine Lindroos-Christensen, Elisa Einwallner, Julia Husa, Nadine Witzeneder, Sabine Rauscher, Marion Groger, Sophia Derdak, Thomas Mohr, Hedwig Sutterluty, Florian Klinglmuller, Silviya Wolkerstorfer, Martina Fondi, Gregor Hoermann, Lei Cao, Oswald Wagner, Florian W. Kiefer, Harald Esterbauer, Martin Bilban
Summary: LMO3 can improve the function of visceral adipose tissue during obesity, promoting glucose uptake and mitochondrial activity in adipocytes.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Clarissa Berardo, Valeria Calcaterra, Alessia Mauri, Stephana Carelli, Letizia Messa, Francesca Destro, Federica Rey, Erika Cordaro, Gloria Pelizzo, Gianvincenzo Zuccotti, Cristina Cereda
Summary: The prevalence of pediatric obesity is increasing worldwide. This study investigates the transcriptional differences in the subcutaneous adipose tissue of children with different weight status. The results show significant deregulation in both coding and non-coding transcripts in the severe obesity group compared to other weight groups. The deregulation is mainly related to lipid metabolism and bioenergetic processes.
Article
Nutrition & Dietetics
Chengzhe Tao, Yuna Huang, Xuzhao Huang, Zhi Li, Yun Fan, Yan Zhang, Tingya Wan, Liyu Lu, Qiaoqiao Xu, Wei Wu, Di Wu, Feng Zhang, Chuncheng Lu
Summary: This study found a positive association between blood Mn levels and visceral adipose tissue (VAT) mass as well as the risk of visceral obesity. The association was stronger in males, especially those with lower family income-to-poverty ratio.
Review
Endocrinology & Metabolism
Maria Alessandra Gammone, Nicolantonio D'Orazio
Summary: Obesity is an independent risk factor for critical illness and severity in COVID-19 patients, with the role of visceral fat in metabolic abnormalities still unclear. Adipose tissue serves as a direct source of cytokines responsible for pathological changes in obese individuals, and dysregulation of adipokines in obesity contributes to chronic low-grade inflammation and metabolic comorbidities. Targeting molecular mechanisms might hold therapeutic potential for managing obesity-related complications in COVID-19 patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiwon Lim, Yerim Heo, Sun Shim Choi
Summary: DNAm is important for regulating cellular activities, and this study investigated its alterations in obesity. Using methylome and transcriptome data, differentially methylated probes (DMPs) were identified between adipocytes and preadipocytes, as well as between obese and lean adipocytes. The study also examined the impact of hyper and hypomethylation on gene expression changes. Interestingly, greater DNAm alterations were observed during adipocyte differentiation under lean conditions compared to obese conditions. Overall, complex methylation changes affected adipogenesis-related genes, leading to differences in gene expression between lean and obese adipocytes.
Article
Multidisciplinary Sciences
Gemma Carreras-Badosa, Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Silvia Xargay-Torrent, Anna Prats-Puig, Elsa Puerto-Carranza, Francis de Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
Summary: GDF-15 is positively associated with immunoglobulin levels in apparently healthy children, especially in those with higher body mass index or renal fat accumulation, suggesting a potential role of GDF-15 in regulating the immune adaptive system in human obesity.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Anahita Jalilvand, Alecia Blaszczak, David Bradley, Joey Liu, Valerie Wright, Bradley Needleman, Willa Hsueh, Sabrena Noria
Summary: The study found that lower visceral AT-Treg abundance in bariatric surgery patients was associated with increased baseline medication requirements for type 2 diabetes, hypertension, and hyperlipidemia, suggesting a correlation between reduced AT-Tregs and higher obesity-related comorbidity severity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Endocrinology & Metabolism
M. R. Panasevich, G. M. Meers, M. A. Linden, F. W. Booth, J. W. Perfield, K. L. Fritsche, Umesh D. Wankhade, Sree V. Chintapalli, K. Shankar, J. A. Ibdah, R. S. Rector
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Review
Biochemistry & Molecular Biology
Sathish Kumar Natarajan, Jamal A. Ibdah
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Fatiha Nassir, Justin J. Arndt, Sarah A. Johnson, Jamal A. Ibdah
JOURNAL OF LIPID RESEARCH
(2018)
Article
Endocrinology & Metabolism
Nathan C. Winn, Ying Liu, R. Scott Rector, Elizabeth J. Parks, Jamal A. Ibdah, Jill A. Kanaley
METABOLISM-CLINICAL AND EXPERIMENTAL
(2018)
Article
Endocrinology & Metabolism
Nathan C. Winn, Rebeca Acin-Perez, Makenzie L. Woodford, Sarah A. Hansen, Megan M. Haney, Lolade A. Ayedun, R. Scott Rector, Victoria J. Vieira-Potter, Orian S. Shirihai, Harold S. Sacks, Jill A. Kanaley, Jaume Padilla
Article
Endocrinology & Metabolism
John P. Thyfault, R. Scott Rector
Review
Endocrinology & Metabolism
Mary P. Moore, Rory P. Cunningham, Ryan J. Dashek, Justine M. Mucinski, R. Scott Rector
Article
Medicine, General & Internal
Ahmad Hassan Ali, Gregory F. Petroski, Alberto A. Diaz-Arias, Alhareth Al Juboori, Andrew A. Wheeler, Rama R. Ganga, James B. Pitt, Nicole M. Spencer, Ghassan M. Hammoud, R. Scott Rector, Elizabeth J. Parks, Jamal A. Ibdah
Summary: In obese patients undergoing metabolic surgery, there is a significant relationship between serum alkaline phosphatase (ALP) and liver fibrosis, along with other noninvasive parameters. The study identified ALP, alanine aminotransferase (ALT), HbA1c, and body mass index (BMI) as independent predictors of significant fibrosis. The development of a tree-based model showed a high accuracy in predicting significant fibrosis, indicating the potential applicability of serum ALP as a biomarker in obese patients with nonalcoholic fatty liver disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ahmad Hassan Ali, Alhareth Al Juboori, Gregory F. Petroski, Alberto A. Diaz-Arias, Majid M. Syed-Abdul, Andrew A. Wheeler, Rama R. Ganga, James B. Pitt, Nicole M. Spencer, Ghassan M. Hammoud, R. Scott Rector, Elizabeth J. Parks, Jamal A. Ibdah
Summary: The diagnostic accuracy of Fibroscan in predicting significant liver fibrosis in morbidly obese patients (BMI>=40 kg/m(2)) is 71.3%. A model incorporating hemoglobin A1c and alkaline phosphatase with liver stiffness measurement improves accuracy in detecting significant fibrosis in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Raghu Ramanathan, Jamal A. Ibdah
Summary: The liver is a highly mitochondrial-rich organ that plays a crucial role in various metabolic processes. Mitochondrial dysfunction is associated with liver diseases, particularly fatty liver disease. Acute fatty liver of pregnancy (AFLP) is a life-threatening liver disorder unique to pregnant women, and its pathogenesis has been linked to mitochondrial dysfunction and fetal fatty-acid oxidation defects. This review provides an overview of AFLP and mitochondrial fatty-acid oxidation, highlighting the importance of altered mitochondrial function in the development of AFLP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rory P. Cunningham, Mary P. Moore, Ryan J. Dashek, Grace M. Meers, Vivien Jepkemoi, Takamune Takahashi, Victoria J. Vieira-Potter, Jill A. Kanaley, Frank W. Booth, R. Scott Rector
Summary: This study demonstrates for the first time the requirement of eNOS in hepatocytes for the exercise-induced increase in hepatic fatty acid oxidation in male mice. Deletion of eNOS in hepatocytes also appears to impair the energy-sensing ability of the cell and inhibit the activation of the autophagy initiating factor ULK1.
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Review
Biochemistry & Molecular Biology
Raghu Ramanathan, Ahmad Hassan Ali, Jamal A. Ibdah
Summary: Nonalcoholic fatty liver disease (NAFLD) is a global pandemic strongly associated with metabolic syndromes. Metabolic-associated fatty liver disease (MAFLD) is suggested as a more appropriate term to describe the disease, emphasizing the role of metabolic dysfunction. Mitochondrial dysfunction plays a significant role in NAFLD development and targeting mitochondria shows promise for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Akwi Wasi Asombang, Richard Madsen, Michelo Simuyandi, Gilbert Phiri, Matthew Bechtold, Jamal Ahmad Ibdah, Kennedy Lishimpi, Lewis Banda
PAN AFRICAN MEDICAL JOURNAL
(2018)
Article
Gastroenterology & Hepatology
Ala' A. Abdel Jali, Ghassan Hammoud, Jamal A. Ibdah, Sami Samiullah
CLINICAL ENDOSCOPY
(2018)