Article
Biochemistry & Molecular Biology
Chin-Sung Kuo, Chi-Yu Chen, Hsin-Lei Huang, Hsiao-Ya Tsai, Ruey-Hsing Chou, Jih-Hua Wei, Po-Hsun Huang, Shing-Jong Lin
Summary: This study demonstrates that melatonin pretreatment can restore endothelial progenitor cell (EPC) function impairment and improve circulation recovery in a diabetic critical limb ischemia mouse model. Melatonin reverses the harmful effects of hyperglycemia on EPC through AMPK-related mechanisms and increases eNOS phosphorylation and heme oxygenase-1 expression. Melatonin treatment augments EPC function and neovascularization in response to ischemia in diabetic mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Stephanie Simoncini, Simon Toupance, Carlos Labat, Sylvie Gautier, Chloe Dumoulin, Laurent Arnaud, Maria G. Stathopoulou, Sophie Visvikis-Siest, Pascal M. Rossi, Athanase Benetos, Francoise Dignat-George, Florence Sabatier
Summary: This study investigates the relationship between atherosclerotic cardiovascular disease (ASCVD), inflammation markers, and circulating endothelial progenitor cells. The findings suggest that ASCVD impairs the colony forming capacity and angiogenic properties of endothelial colony forming cells (ECFC) in a severity-dependent manner. Additionally, alteration of ECFC is associated with increased senescent phenotype and IL-6 levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Huang-Ming Chang, Kang-Yung Peng, Chieh-Kai Chan, Chiao-Yin Sun, Ying-Ying Chen, Han-Mei Chang, Chun-Lin Huang, Pei-Chun Liu, Peng-Ying Chen, Kuo-Chuan Wang, Wei-Jie Wang, Chen-Chi Wu, Yu-Feng Lin, Tai-Shuan Lai, Tao-Min Huang, Guang-Huar Young, Shuei-Liong Lin, Marlies Ostermann, Tzong-Shinn Chu, Jeff S. Chueh, Vin-Cent Wu
Summary: This study reveals the protective role of FGF23 in AKI, promoting renal regeneration, vascular repair, and attenuating damage. FGF23 interacts with the SDF-1/CXCR4 signaling, inhibiting EPC senescence and migration, while not affecting angiogenesis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hyeok Kim, Soon-Jung Park, Jae-Hyun Park, Sunghun Lee, Bong-Woo Park, Soon Min Lee, Ji-Won Hwang, Jin-Ju Kim, Byeongmin Kang, Woo-Sup Sim, Hyo-Jin Kim, Seung Hwan Jeon, Dong-Bin Kim, Jinah Jang, Dong-Woo Cho, Sung-Hwan Moon, Hun-Jun Park, Kiwon Ban
Summary: Researchers have successfully used a combination of two different types of stem cells to repair failed hearts by creating new blood vessels. This dual stem cell treatment improves cardiac function and results in a higher number of larger and stronger new blood vessels.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Veronica Pulito-Cueto, Sara Remuzgo-Martinez, Fernanda Genre, Belen Atienza-Mateo, Victor M. Mora-Cuesta, David Iturbe-Fernandez, Leticia Lera-Gomez, Raquel Perez-Fernandez, Diana Prieto-Pena, Virginia Portilla, Ricardo Blanco, Alfonso Corrales, Oreste Gualillo, Jose M. Cifrian, Raquel Lopez-Mejias, Miguel A. Gonzalez-Gay
Summary: Research has shown a significant increase in EPC frequency in SSc-ILD+ patients, which may be related to the pathogenic processes of vasculopathy and lung fibrosis. Additionally, EPC frequency was higher in male patients and negatively correlated with disease duration in SSc patients.
Article
Biochemistry & Molecular Biology
Flavy Roseren, Martine Pithioux, Stephane Robert, Laure Balasse, Benjamin Guillet, Edouard Lamy, Sandrine Roffino
Summary: The study showed that G-CSF can accelerate bone regeneration and modulate the mobilization of progenitor cells during the process of distraction osteogenesis, promoting bone consolidation. In the early phase of consolidation, the G-CSF group exhibited lower osteoclast activity and a trend of increased osteoblast activity, while significantly lower neovascularization was observed in the late phase of consolidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Maria Vazquez-Reza, Antia Custodia, Iria Lopez-Dequidt, Marta Aramburu-Nunez, Daniel Romaus-Sanjurjo, Alberto Ouro, Joao Botelho, Vanessa Machado, Ramon Iglesias-Rey, Juan Manuel Pias-Peleteiro, Rogelio Leira, Juan Blanco, Jose Castillo, Tomas Sobrino, Yago Leira
Summary: This study investigates the relationship between periodontitis and an increased number of circulating endothelial progenitor cells (EPCs) (CD34(+)/CD133(+)/KDR+). The results show that periodontitis patients have a higher concentration of EPCs compared to non-periodontitis patients, and there is a significant increase in EPCs over time in patients with periodontitis. These findings suggest a potential link between periodontitis and endothelial dysfunction.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Review
Cell & Tissue Engineering
Sarah E. J. Chambers, Varun Pathak, Edoardo Pedrini, Lou Soret, Nicolas Gendron, Coralie L. Guerin, Alan W. Stitt, David M. Smadja, Reinhold J. Medina
Summary: Ischemic vascular disease is a major global cause of mortality and morbidity, and the therapeutic goal of regenerating blood vessels in perfusion-deficient tissues through delivering endothelial stem/progenitor cells has strong scientific basis. However, challenges and contradictions in clinical trials have highlighted the difficulties in developing endothelial stem cell therapies. Emerging evidence raises questions about the traditional view of bone marrow as the source of these cells and suggests the vascular wall as the niche for tissue-resident endothelial stem cells.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Surgery
Maxim Geeroms, Satoshi Fujimura, Emiko Aiba, Doruk Orgun, Kayo Arita, Rie Kitamura, Daiki Senda, Hiroshi Mizuno, Moustapha Hamdi, Rica Tanaka
Summary: Human mononuclear cells cultured with the quality and quantity method (MNC-QQ) show enhanced vasculogenic potential compared to PBMNC and stromal vascular fraction, leading to improved vascularization and survival of fat grafts.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Cell & Tissue Engineering
Jui-Po Yeh, Pei-Hsun Sung, John Y. Chiang, Chi-Ruei Huang, Yi-Ling Chen, Jui-Pin Lai, Jiunn-Jye Sheu
Summary: This study found that overexpression of cellular prion protein in endothelial progenitor cells was more effective than using endothelial progenitor cells alone in treating critical limb ischemia induced by chronic kidney disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Jasenka Guduric-Fuchs, Edoardo Pedrini, Judith Lechner, Sarah E. J. Chambers, Christina L. O'Neill, Joana Mendes Lopes de Melo, Varun Pathak, Rachel H. Church, Stuart McKeown, James Bojdo, Kiran J. Mcloughlin, Alan W. Stitt, Reinhold J. Medina
Summary: miR-130a acts as a mediator in the hypoxic response of ECFCs, enhancing their angiogenic and vasoreparative abilities by coordinating the upregulation of VEGFR2/STAT3/HIF1 alpha axis through translational inhibition of Ddx6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Ji Li, Yan Ma, Xiao-Hui Miao, Ji-Dong Guo, Da-Wei Li
Summary: Endothelial progenitor cells (EPCs) are immature cells capable of proliferating and differentiating into mature endothelial cells (ECs) to repair injured endothelium and form new blood vessels. The regenerative capacity of EPCs is tightly regulated by endogenous and exogenous factors as well as vascular risk factors. Understanding these regulatory mechanisms is crucial for effectively using EPCs in treating vascular diseases like ischemic stroke.
NEUROLOGICAL SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Sandrine Lecour, Bastiaan C. Du Pre, Hans Erik Botker, Bianca J. J. M. Brundel, Andreas Daiber, Sean M. Davidson, Peter Ferdinandy, Henrique Girao, Can Gollmann-Tepekoeylu, Mariann Gyoengyoesi, Derek J. Hausenloy, Rosalinda Madonna, Michael Marber, Cinzia Perrino, Maurizio Pesce, Rainer Schulz, Joost P. G. Sluijter, Sabine Steffens, Sophie Van Linthout, Martin E. Young, Linda W. Van Laake
Summary: Circadian rhythms play a crucial role in cardiovascular diseases and should be considered as a key research parameter to improve understanding of cardiac physiology/pathology and enhance the translation and efficacy of cardiac therapies. The aim is to highlight key aspects of circadian rhythms for the improvement of preclinical and translational studies related to ischemic heart disease and cardioprotection, which may lead to better clinical outcomes.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Jolanda van der Velden, Folkert W. Asselbergs, Jeroen Bakkers, Sandor Batkai, Luc Bertrand, Connie R. Bezzina, Ilze Bot, Bianca J. J. M. Brundel, Lucie Carrier, Steven Chamuleau, Michele Ciccarelli Dana Dawson, Sean M. Davidson, Andreas Dendorfer, Dirk J. Duncker, Thomas Eschenhagen, Larissa Fabritz, Ines Falcao-Pires, Peter Ferdinandy, Mauro Giacca, Henrique Girao, Can Gollmann-Tepekoeylue, Mariann Gyongyosi, Tomasz J. Guzik, Nazha Hamdani, Stephane Heymans, Andres Hilfiker, Denise Hilfiker-Kleiner, Alfons G. Hoekstra, Jean-Sebastien Hulot, Diederik W. D. Kuster, Linda W. van Laake, Sandrine Lecour, Tim Leiner, Wolfgang A. Linke, Joost Lumens, Esther Lutgens, Rosalinda Madonna, Lars Maegdefessel, Manuel Mayr, Peter van der Meer, Robert Passier, Filippo Perbellini, Cinzia Perrino, Maurizio Pesce, Silvia Priori, Carol Ann Remme, Bodo Rosenhahn, Ulrich Schotten, Rainer Schulz, Karin R. Sipido, Joost P. G. Sluijter, Frank van Steenbeek, Sabine Steffens, Cesare M. Terracciano, Carlo Gabriele Tocchetti, Patricia Vlasman, Kak Khee Yeung, Serena Zacchigna, Dayenne Zwaagman, Thomas Thum, Michele Ciccarelli
Summary: Cardiovascular diseases are a major cause of illness and death, and research is needed to improve diagnostics and discover new preventive and curative therapies. Translating basic science to clinical practice is challenging for complex conditions like cardiovascular diseases, which are often caused by multiple risk factors and comorbidities. Animal models play a vital role in providing important pathophysiological insights into disease mechanisms, particularly on an organ and systemic level.
CARDIOVASCULAR RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Sabine Steffens, Matthias Nahrendorf, Rosalinda Madonna
Summary: The use of single-cell immune profiling and advanced microscopic imaging technologies has enhanced our understanding of the cardiac immune system and its role in cardiac diseases.
EUROPEAN HEART JOURNAL
(2022)
Article
Cell Biology
Rosalinda Madonna, Damiana Pieragostino, Maria Concetta Cufaro, Piero Del Boccio, Angela Pucci, Letizia Mattii, Vanessa Doria, Christian Cadeddu Dessalvi, Riccardo Zucchi, Giuseppe Mercuro, Raffaele De Caterina
Summary: Ponatinib, a tyrosine kinase inhibitor used in chronic myeloid leukaemia, has been shown to have cardiovascular toxicity. This study investigated the mechanisms of sex-related Ponatinib-induced cardiotoxicity and identified rescue strategies using a mouse model. The results demonstrated sex-related differences in the cardiotoxicity of Ponatinib and the involvement of sex hormones.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Rosalinda Madonna, Serena Barachini, Stefania Moscato, Chiara Ippolito, Letizia Mattii, Chiara Lenzi, Carmela Rita Balistreri, Riccardo Zucchi, Raffaele De Caterina
Summary: This study investigated the effects of SGLT2 inhibitors on PON-induced endothelial cell toxicity. The results showed that EMPA and DAPA could reverse the effects of PON on cell viability, cell senescence, and cell tubulization, thereby attenuating PON-induced vascular toxicity.
VASCULAR PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Rosalinda Madonna
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Nino Cocco, Rosalinda Madonna, Valeria Cammalleri, Giulio Cocco, Domenico De Stefano, Danilo Ricciardi, Francesco Grigioni, Gian Paolo Ussia
Summary: Anomalous aortic origin of a coronary artery (AAOCA) is associated with an increased risk of myocardial ischemia and sudden death. The exact pathophysiology of AAOCA is not well understood, leading to a lack of well-defined clinical management. With the increased use of non-invasive imaging, the diagnosis of AAOCA is increasing and the association with atherosclerotic diseases is becoming more important.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Rosalinda Madonna, Stefania Moscato, Maria Concetta Cufaro, Damiana Pieragostino, Letizia Mattii, Piero Del Boccio, Sandra Ghelardoni, Riccardo Zucchi, Raffaele De Caterina
Summary: This study found that empagliflozin can inhibit excessive autophagy in the heart of diabetic patients by suppressing the AMPK/GSK3β signaling pathway, thus protecting the heart from damage.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Rosalinda Madonna
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Rosalinda Madonna, Lorenzo Ridolfi, Riccardo Morganti, Filippo Biondi, Silvia Fabiani, Arianna Forniti, Riccardo Iapoce, Raffaele De Caterina
Summary: This study investigated the prognostic significance of exercise-induced pulmonary hypertension (ExPH) in HIV-affected patients and found that ExPH may predict an increasing trend of cardiovascular risk over time in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Giovanna Manzi, Marco Valerio Mariani, Domenico Filomena, Roberto Poscia, Paolo Severino, Antonio Iaconelli, Tommaso Recchioni, Rosalinda Madonna, Carmine Dario Vizza, Roberto Badagliacca
Summary: Heart failure (HF) is a significant health and economic issue, and current therapeutic approaches are ineffective due to the complexity of the syndrome. The European Union is developing policies to shift towards precision medicine and identify specific disease biomarkers for targeted therapies. The establishment of biobanks could revolutionize HF treatment by providing a collection of human biological materials and associated data for personalized approaches and research projects.
VASCULAR PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Serena Barachini, Sandra Ghelardoni, Rosalinda Madonna
Summary: Vascular progenitor cells are activated to repair and form a neointima following various vascular damages. They not only play a role in resolving vascular lesions, but also contribute to neovascularization and angiogenesis associated with cancer. This review discusses the biology and pathophysiology of vascular progenitor cells, including their origins, stimuli, and activated pathways. It focuses on their involvement in tumor-induced vascular injury and their implications in promoting tumor angiogenesis during cancer proliferation and migration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Donato Santovito, Sabine Steffens, Serena Barachini, Rosalinda Madonna
Summary: Autophagy is a cellular mechanism that helps cells adapt to metabolic and environmental stress. It plays a crucial role in clearing protein aggregates and dysfunctional organelles, and recent studies have shown its broader role in various pathophysiological conditions. Basal autophagy is essential for maintaining cardiac homeostasis and protecting against age-related cell damage and genomic instability. Additionally, autophagy is stimulated in response to cardiac injuries such as ischemia, pressure overload, and metabolic stress. It also affects the function of neutrophils and other immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Serena Barachini, Sandra Ghelardoni, Zoltan V. Varga, Radwa A. Mehanna, Maria Magdalena Montt-Guevara, Peter Ferdinandy, Rosalinda Madonna
Summary: With the improvement in cancer prognosis, there has been an increase in survival rate among cancer survivors. However, the use of anti-neoplastic drugs has led to an increase in morbidity among these survivors due to cardiovascular complications. These complications include arrhythmias, myocardial ischemia, heart failure, arterial hypertension, thromboembolic events, and accelerated atherosclerosis. The drugs not only target cancer cells but also affect normal cells within the cardiovascular system, leading to toxicity.
VASCULAR PHARMACOLOGY
(2023)
