Extracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesis

Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling

(2014) M. Capurro et al.   JOURNAL OF CELL SCIENCE

Scaling of Dorsal-Ventral Patterning by Embryo Size-Dependent Degradation of Spemann’s Organizer Signals

(2013) Hidehiko Inomata et al.   CELL

Hedgehog on the move: a precise spatial control of Hedgehog dispersion shapes the gradient

(2013) Ana-Citlali Gradilla et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Generation and interpretation of FGF morphogen gradients in vertebrates

(2013) Christian Bökel et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Extracellular modulation of Fibroblast Growth Factor signaling through heparan sulfate proteoglycans in mammalian development

(2013) Isao Matsuo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Heparan Sulfate Proteoglycans Containing a Glypican 5 Core and 2-O-Sulfo-iduronic Acid Function as Sonic Hedgehog Co-receptors to Promote Proliferation

(2013) Rochelle M. Witt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Creating gradients by morphogen shuttling

(2013) Ben-Zion Shilo et al.   TRENDS IN GENETICS

Encoding and decoding of positional information in morphogen-dependent patterning

(2012) Ken-ichi Hironaka et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing

(2012) J. Chen et al.   DEVELOPMENT

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling

(2012) K. L. Ayers et al.   DEVELOPMENT

Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development

(2012) X. Qu et al.   DEVELOPMENT

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

(2012) Satoshi Nagamine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Facilitates FGF and BMP Signaling to Drive Mesoderm Differentiation of Mouse Embryonic Stem Cells

(2012) Daniel C. Kraushaar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Emerging Role of Sonic Hedgehog Shedding as a Modulator of Heparan Sulfate Interactions

(2012) Stefanie Ohlig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Sulfation Remodelling of Heparan Sulfate by Extracellular 6-O-Sulfatases Regulates Fibroblast Growth Factor-Induced Boundary Formation by Glial Cells: Implications for Glial Cell Transplantation

(2012) J. R. Higginson et al.   JOURNAL OF NEUROSCIENCE

Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis

(2012) A. Elfenbein et al.   Science Signaling

Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate

(2012) Laurence Duchesne et al.   PLOS BIOLOGY

Morphogen Gradients: From Generation to Interpretation

(2011) Katherine W. Rogers et al.   Annual Review of Cell and Developmental Biology

Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling

(2011) Sabine Fischer et al.   BMC DEVELOPMENTAL BIOLOGY

Cell Surface Heparan Sulfate Chains Regulate Local Reception of FGF Signaling in the Mouse Embryo

(2011) Kayo Shimokawa et al.   DEVELOPMENTAL CELL

Novel Contact-dependent Bone Morphogenetic Protein (BMP) Signaling Mediated by Heparan Sulfate Proteoglycans

(2011) Katsufumi Dejima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lacrimal Gland Development and Fgf10-Fgfr2b Signaling Are Controlled by 2-O- and 6-O-sulfated Heparan Sulfate

(2011) Xiuxia Qu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling

(2011) Fuchuan Li et al.   JOURNAL OF CELL BIOLOGY

Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking

(2011) Matthias Nowak et al.   NATURE CELL BIOLOGY

Hedgehog morphogen: from secretion to reception

(2011) Armel Gallet   TRENDS IN CELL BIOLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Heparan Sulfate-Dependent Signaling of Fibroblast Growth Factor 18 by Chondrocyte-Derived Perlecan

(2010) Christine Y. Chuang et al.   BIOCHEMISTRY

The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development

(2010) D. Yan et al.   DEVELOPMENT

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation

(2010) Adam Kleinschmit et al.   DEVELOPMENTAL BIOLOGY

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Conditional Ablation of the Heparan Sulfate-synthesizing EnzymeExt1Leads to Dysregulation of Bone Morphogenic Protein Signaling and Severe Skeletal Defects

(2010) Yoshihiro Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Domain Organization and Sulfation Modulate FGF-induced Cell Signaling

(2010) Nadja Jastrebova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Acts as a Bone Morphogenetic Protein Coreceptor by Facilitating Ligand-induced Receptor Hetero-oligomerization

(2010) Wan-Jong Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The signaling mechanisms of syndecan heparan sulfate proteoglycans

(2009) Kathleen Lambaerts et al.   CURRENT OPINION IN CELL BIOLOGY

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Heparan Sulfate and Transglutaminase Activity Are Required for the Formation of Covalently Cross-linked Hedgehog Oligomers

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

(2009) J. Kalinina et al.   MOLECULAR AND CELLULAR BIOLOGY

FGF9 monomer–dimer equilibrium regulates extracellular matrix affinity and tissue diffusion

(2009) Masayo Harada et al.   NATURE GENETICS

Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo

(2009) Sebastian J. Arnold et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

(2009) H. P. Makarenkova et al.   Science Signaling

Establishing and Interpreting Graded Sonic Hedgehog Signaling during Vertebrate Neural Tube Patterning: The Role of Negative Feedback

(2009) V. Ribes et al.   Cold Spring Harbor Perspectives in Biology

Shaping Morphogen Gradients by Proteoglycans

(2009) D. Yan et al.   Cold Spring Harbor Perspectives in Biology

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

(2008) C. Settembre et al.   GENES & DEVELOPMENT

Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation

(2008) Vaishali N. Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

(2007) Takuya Akiyama et al.   DEVELOPMENTAL BIOLOGY