Review
Chemistry, Inorganic & Nuclear
Darren F. Beirne, Martina Dalla Via, Trinidad Velasco-Torrijos, Diego Montagner
Summary: Tyrosine Kinases play a crucial role in cancer, but small molecule Tyrosine Kinase Inhibitors face limitations in clinical usage. Metal-Tyrosine Kinase Inhibitor conjugates have emerged as a promising area of research to overcome these limitations, with potential applications in multiple biological fields.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Mireia Sueca-Comes, Elena Cristina Rusu, Anna M. Grabowska, David O. Bates
Summary: The number of cancer drugs is increasing, but most research is still focused on a small subset of well-studied targets, with limited investigations into poorly studied kinases.
PHARMACOLOGICAL REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
Summary: This review emphasizes the role of protein kinases as potential biological targets in pain management, categorizing them into different groups in the human kinome and describing examples of small molecule inhibitors demonstrating analgesic effects. It highlights the fundamental role that protein kinase inhibitors could play in the development of new pain treatments.
Article
Biochemistry & Molecular Biology
Dawid Polak, Marcin Talar, Nina Wolska, Dagmara W. Wojkowska, Kamil Karolczak, Karol Kramkowski, Tomasz A. Bonda, Cezary Watala, Tomasz Przygodzki
Summary: The A(2A) agonist HE-NECA in low doses in combination with inhibitors of P2Y(12) improved anti-thrombotic properties and was effective with chronic administration. Additionally, HE-NECA has hypotensive effects but does not significantly affect blood-brain barrier permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lucia Garcia-Garcia, Laia Olle, Margarita Martin, Jordi Roca-Ferrer, Rosa Munoz-Cano
Summary: Adenosine, through its binding to different G protein-coupled receptors, can have either anti-inflammatory or pro-inflammatory effects, with A2a receptor typically showing anti-inflammatory activity. Understanding the mechanisms of action of adenosine on specific receptors may lead to the development of more effective therapies for allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Zhiwei Ma, Sheng-You Huang, Fei Cheng, Xiaoqin Zou
Summary: Efficient ensemble docking algorithm is applied to dock ligands against multiple protein targets simultaneously. Using protein kinases as an example, the algorithm is shown to be effective in screening for inhibitors and investigating their selectivities for multiple target proteins.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Tobias Claff, Tim A. Klapschinski, Udaya K. Tiruttani Subhramanyam, Victoria J. Vaassen, Jonathan G. Schlegel, Christin Vielmuth, Jan H. Voss, Joerg Labahn, Christa E. Mueller
Summary: Researchers developed a new A(2A)AR construct and successfully co-crystallized it with Preladenant derivatives, providing explanations for their high potency and selectivity through crystal structures. This study is of great importance for further research on class A GPCRs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Medicinal
Maria Antonietta Occhiuzzi, Gernando Lico, Giuseppina Ioele, Michele De Luca, Antonio Garofalo, Fedora Grande
Summary: The PI3K/PKB/mTOR signaling pathway has a well-known biochemical role in cell-cycle regulation. It becomes overactive during the development of cancer, promoting cell proliferation and inhibiting apoptosis. Therefore, targeting this pathway has become important in the treatment of various malignant tumors. Selective inhibitors have been identified, but drugs that target multiple proteins within the pathway have shown higher efficacy and limited drug resistance, making them promising anticancer agents. This survey focuses on small molecule drugs capable of modulating the PI3K/PKB/mTOR signaling pathway as potential pharmacological treatments for cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Teng Zhang, Li Yu-Jing, Tao Ma
Summary: This paper discusses the role of adenosine in the pathogenesis of sepsis and the regulatory activities of adenosine receptors. Animal models have shown that adenosine may be a potential target for treating sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Baptiste Maille, Nathalie Lalevee, Marion Marlinge, Juliette Vahdat, Giovanna Mottola, Clara Degioanni, Lucille De Maria, Victor Klein, Franck Thuny, Frederic Franceschi, Jean-Claude Deharo, Regis Guieu, Julien Fromonot
Summary: This narrative review discusses the potential role of the adenosinergic system in the pathophysiology of atrial fibrillation (AF). It provides insights into adenosinergic system signaling and its interactions with AF. Activation of adenosine receptors can affect the occurrence and maintenance of AF, and the adenosinergic system is also associated with the modulation of the autonomic nervous system and AF risk factors.
Review
Neurosciences
Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel
Summary: Despite progress in understanding the pathogenesis of hyperexcitable networks and lowered seizure thresholds, treating epilepsy remains challenging. Many patients are resistant to current medications, which only provide symptomatic relief. Efforts are focused on finding new treatments with novel mechanisms of action to modify disease progression. Purines like ATP and adenosine play key roles in the epileptogenic process, with potential as targets for therapeutic strategies.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Cell Biology
Michele Zanoni, Anna Pegoraro, Elena Adinolfi, Elena De Marchi
Summary: Resistance to therapy remains a critical obstacle in cancer treatment. Purinergic signaling plays a pivotal role in the regulation of cancer cell metabolism, inflammation, and development. Targeting purinergic signaling may have translational applications in combination with conventional anticancer interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Srdjan M. M. Vlajkovic, Peter R. R. Thorne
Summary: The mammalian cochlea, as the sensory organ for hearing, is regulated by ATP release and adenosine signaling, triggering various physiological responses and playing important roles in cochlear development, homeostasis, and sensory transduction. Understanding these mechanisms may provide therapeutic strategies for cochlear rescue and prevention of hearing loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Sheng Wang, Songsen Gao, Dexi Zhou, Xueyi Qian, Jiajie Luan, Xiongwen Lv
Summary: Extracellular ATP serves as a danger signal released by dying and damaged cells, promoting inflammation as an immunostimulatory signal. CD39 and CD73 play critical roles in liver disease by breaking down ATP into adenosine, shifting from a proinflammatory to an anti-inflammatory environment. The modification of the CD39-CD73-adenosine pathway alters the liver's response to injury and adenosine exerts different effects on liver pathophysiology through different receptors.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jinan Wang, Apurba Bhattarai, Hung N. Do, Sana Akhter, Yinglong Miao
Summary: G protein-coupled receptors (GPCRs) are the largest family of human membrane proteins, with adenosine receptors (ARs) having four subtypes that mediate various physiological functions and serve as drug targets. Adenosine receptors have different coupling preferences with G proteins, leading to future research opportunities in drug discovery.
Article
Biochemistry & Molecular Biology
Grzegorz Cholewinski, Dorota Iwaszkiewicz-Grzes, Piotr Trzonkowski, Krystyna Dzierzbicka
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Organic
Monika Kukowska, Magdalena Kukowska-Kaszuba, Krystyna Dzierzbicka
TETRAHEDRON LETTERS
(2015)
Review
Oncology
Agnieszka Siebert, Monika Gensicka, Grzegorz Cholewinski, Krystyna Dzierzbicka
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2016)
Correction
Chemistry, Medicinal
Wioleta Januchta, Marcin Serocki, Krystyna Dzierzbicka, Grzegorz Cholewinski, Andrzej Skladanowski
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Plant Sciences
Michal Prejs, Grzegorz Cholewinski, Agnieszka Siebert, Piotr Trzonkowski, Krystyna Dzierzbicka
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2016)
Article
Chemistry, Multidisciplinary
Monika Kukowska, Michal Pikula, Magdalena Kukowska-Kaszuba, Adriana Schumacher, Krystyna Dzierzbicka, Piotr Trzonkowski
Article
Chemistry, Multidisciplinary
Wioleta Januchta, Marcin Serocki, Krystyna Dzierzbicka, Grzegorz Cholewinski, Monika Gensicka, Andrzej Skladanowski
Article
Immunology
Dorota Iwaszkiewicz-Grzes, Grzegorz Cholewinski, Agata Kot-Wasik, Piotr Trzonkowski, Krystyna Dzierzbicka
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Review
Chemistry, Medicinal
Agnieszka Siebert, Michal Prejs, Grzegorz Cholewinski, Krystyna Dzierzbicka
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2017)
Review
Chemistry, Multidisciplinary
Monika Gensicka-Kowalewska, Grzegorz Cholewinski, Krystyna Dzierzbicka
Review
Neurosciences
Maja Przybylowska, Szymon Kowalski, Krystyna Dzierzbicka, Iwona Inkielewicz-Stepniak
CURRENT NEUROPHARMACOLOGY
(2019)
Article
Plant Sciences
Michal Prejs, Grzegorz Cholewinski, Piotr Trzonkowski, Agata Kot-Wasik, Krystyna Dzierzbicka
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Grzegorz Cholewinski, Dorota Iwaszkiewicz-Grzes, Michal Prejs, Agnieszka Glowacka, Krystyna Dzierzbicka
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2015)
Article
Oncology
Miroslawa Cichorek, Anna Ronowska, Monika Gensicka-Kowalewska, Milena Deptula, Iwona Pelikant-Malecka, Krystyna Dzierzbicka
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Agnieszka Siebert, Monika Gensicka-Kowalewska, Grzegorz Cholewinski, Krystyna Dzierzbicka
CURRENT MEDICINAL CHEMISTRY
(2017)