RIP1K and RIP3K provoked by shikonin induce cell cycle arrest in the triple negative breast cancer cell line, MDA-MB-468: necroptosis as a desperate programmed suicide pathway

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells

(2015) Rong Tian et al.   BIOSCIENCE REPORTS

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

(2015) Xinfang Yu et al.   Oncotarget

Programmed necrosis and necroptosis signalling

(2014) Maria Feoktistova et al.   FEBS Journal

Cross-talk between Endoplasmic Reticulum (ER) Stress and the MEK/ERK Pathway Potentiates Apoptosis in Human Triple Negative Breast Carcinoma Cells

(2014) Swatilekha Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shikonin Inhibits the Proliferation of Human Lens Epithelial Cells by Inducing Apoptosis through ROS and Caspase-Dependent Pathway

(2014) Wan-Rong Huang et al.   MOLECULES

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic exploitation of necroptosis for cancer therapy

(2014) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes

(2014) Rouhallah Najjar Sadeghi et al.   TUMOR BIOLOGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

Breast tumor subgroups reveal diverse clinical prognostic power

(2014) Zhaoqi Liu et al.   Scientific Reports

The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

(2013) Zeze Fu et al.   BMC CANCER

The mechanism of necroptosis in normal and cancer cells

(2013) Simone Fulda   CANCER BIOLOGY & THERAPY

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Molecular Characterization of Basal-Like and Non-Basal-Like Triple-Negative Breast Cancer

(2013) A. Prat et al.   ONCOLOGIST

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death

(2013) P K Singha et al.   Cell Death & Disease

The flick of a switch: which death program to choose?

(2012) P Vandenabeele et al.   CELL DEATH AND DIFFERENTIATION

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

(2012) Benjamin Wiench et al.   Evidence-based Complementary and Alternative Medicine

Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex

(2012) Seungyeon Park et al.   FOOD AND CHEMICAL TOXICOLOGY

RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy

(2012) Yuan-Chao Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1

(2012) Masoumeh Tavakoli-Yaraki et al.   TUMOR BIOLOGY

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines

(2011) Faranak Fallahian et al.   FEBS Journal

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma

(2011) Ke Gong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Triple-Negative Breast Cancer: An Unmet Medical Need

(2011) C. A. Hudis et al.   ONCOLOGIST

Molecular Stratification of Triple-Negative Breast Cancers

(2011) C. M. Perou   ONCOLOGIST

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

(2009) Weidong Han et al.   APOPTOSIS

A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells

(2009) Yuan Yao et al.   BREAST CANCER RESEARCH AND TREATMENT

Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer

(2009) Carey K. Anders et al.   Clinical Breast Cancer

Apoptosis and cancer: mutations within caspase genes

(2009) S Ghavami et al.   JOURNAL OF MEDICAL GENETICS

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE