Article
Food Science & Technology
Hsin-Ling Yang, Sheng-Teng Huang, Zi-He Lyu, Asif Ali Bhat, Chithravel Vadivalagan, Yu-Lyu Yeh, You-Cheng Hseu
Summary: Coenzyme Q0 (CoQ0) from Antrodia camphorata exhibits therapeutic benefits in cancer treatment by activating apoptotic and autophagic cell death pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Shenghan Gao, Xinyu Zhang, Jie Liu, Fuqing Ji, Zhihao Zhang, Qingjie Meng, Qi Zhang, Xiaogang Han, He Wu, Yulong Yin, Yonggang Lv, Wenzhen Shi
Summary: This study found that icariin (ICA) has an inhibitory effect on triple-negative breast cancer (TNBC) cells by inducing apoptosis and inhibiting cell invasion. The results suggest that ICA may be a potential drug for treating TNBC.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Plant Sciences
Francis Adu-Amankwaah, Kudzanai Ian Tapfuma, Raeesa Hoosen Hussan, Ndivhuwo Tshililo, Lucinda Baatjies, Maano Valerie Masiphephethu, Lawrence Mabasa, Vuyo Mavumengwana
Summary: Breast cancer is a leading cause of cancer-related deaths in women globally. This study investigated the potential use of nine Fynbos plants in treating breast cancer and found that E. racemosa and S. africana-lutea are promising candidates for further development of therapeutic agents.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Food Science & Technology
R. Anusha, M. Ashin, Sulochana Priya
Summary: Ginger exosome-like nanoparticles (GELNs) have been found to inhibit the growth and migration of triple-negative breast cancer (TNBC) cells and induce apoptosis. This study reveals the interaction between GELNs and TNBC cells, as well as the underlying molecular mechanism of their action.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Thien-Nga Chamaraux-Tran, Marie Muller, Julien Pottecher, Pierre A. Diemunsch, Catherine Tomasetto, Izzie-Jacques Namer, Nassim Dali-Youcef
Summary: Metabolomics and onco-anesthesia are emerging research fields in oncology. This study assessed the impact of lidocaine (LIDO) on the metabolomic fingerprint of breast cancer cells. Results showed that LIDO modulates cell metabolites levels and downregulates several pathways, suggesting its potential antitumor properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Shengyu Pu, Yudong Zhou, Peiling Xie, Xiaoqian Gao, Yang Liu, Yu Ren, Jianjun He, Na Hao
Summary: This study identified the significant impact of NRGs on immunity and prognosis in TNBC, providing a new strategy for personalized treatment and improving clinical benefit.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Zhu Wu, Mei-Jia Gao, Jie Chen, Xiao-Long Sun, Ke-Yi Zhang, Yi-Qun Dai, Tao Ma, Hong-Mei Li, Yu-Xin Zhang
Summary: Standardized treatment and effective drugs are lacking for human triple-negative breast cancer (TNBC). In this study, researchers investigated the potential of isobavachalcone (IBC), a natural compound, as an anticancer agent for TNBC. They found that IBC inhibited the proliferation of TNBC cells and induced multiple cell death processes, including apoptosis, necroptosis, and autophagy through various mechanisms. These findings suggest that IBC has potential as a lead compound for anti-TNBC treatment.
Article
Pharmacology & Pharmacy
Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andre du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia Costa-Lotufo, K. N. ArulJothi, Selwyn Mapolie, Sharon Prince
Summary: The study investigated the anti-cancer activity of a palladium complex, BTC2, in human breast cancer cells, demonstrating its selectivity, inhibition of cancer cell migration, and suppression of cancer stem cell activity. BTC2 also induced DNA double strand breaks, triggered cell cycle arrests, and activated multiple cell death pathways, showing promising anti-breast cancer activity both in vitro and in vivo.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daoyu Zhang, Xinglan An, Hao Yu, Ziyi Li
Summary: Breast cancer, especially triple-negative breast cancer, is challenging to treat due to the lack of therapeutic targets. The drug thioguanine has shown antitumor effects and may potentially affect tumor pathways by down-regulating key genes. Competitive endogenous ribonucleic acids may play a role in the regulation of these pathways and could serve as potential targets for alternative breast cancer treatments.
BIOSCIENCE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Citra Dewi, Adryan Fristiohady, Riezki Amalia, Nur Kusaira Khairul Ikram, Sugeng Ibrahim, Muchtaridi Muchtaridi
Summary: Triple-negative breast cancer (TNBC) is the most aggressive subtype with poor prognosis. Natural compounds have gained attention as potential therapeutic agents for TNBC and may offer solutions to drug resistance issues.
Article
Nanoscience & Nanotechnology
Mengyao Chen, Jingxian Yang, Lulu Zhou, Xiaochun Hu, Chunhui Wang, Keke Chai, Ruihao Li, Lei Feng, Yanting Sun, Chunyan Dong, Shuo Shi
Summary: The study presents a smart pH/ROS-responsive nanoplatform Fe2+@UCM-BBD for tumor combination therapy, which exhibits excellent capability of inducing tumor apoptosis through DNA damage, promoting H2O2 production for CDT, and achieving CDT through ROS-responsive mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Leide Laura Figueiredo Maciel, Marina Barreto Silva, Rafaela Oliveira Moreira, Ana Paula Cardoso, Christiane Fernandes, Adolfo Horn Jr, Joao Carlos de Aquino Almeida, Milton Masahiko Kanashiro
Summary: This study investigated the antineoplastic activity of two platinum complexes containing alpha- and beta-naphthyl groups. The results showed that one of the platinum complexes exhibited higher cytotoxicity against all cancer cell lines tested and lower cytotoxicity against normal peripheral blood mononuclear cells. Further investigations revealed that this complex induced cell death by apoptosis and was associated with mitochondrial membrane depolarization, elevated levels of reactive oxygen species (ROS), and caspase activation.
Article
Biochemistry & Molecular Biology
Jin Zhang, Xiya Chen, Gang Chen, Hailing Wang, Lin Jia, Yue Hao, Dahong Yao
Summary: This study proposes the dual targeting of PAK1 and HDAC6 as a promising therapeutic strategy for triple-negative breast cancer (TNBC). A novel dual-targeting PAK1/HDAC6 inhibitor, ZMF-23, showed significant inhibitory activity against PAK1 and HDAC6 and demonstrated robust antiproliferative potency in TNBC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Jingyi Zhou, Kangkang Li, Xinlong Zang, Yi Xie, Jinxiao Song, Xuehong Chen
Summary: Reactive oxygen species (ROS)-responsive galactosylated nanoparticles (DOX@NPs) were developed as a targeted carrier for doxorubicin (DOX) delivery to inhibit the growth of triple negative breast cancer (TNBC). DOX@NPs showed good ROS responsiveness, effectively triggered tumor cell apoptosis and cycle arrest, efficiently accumulated into tumor sites, and suppressed tumor growth without adverse side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Oncology
Marine Lemesle, Marine Geoffroy, Fabien Alpy, Catherine-Laure Tomasetto, Sandra Kuntz, Isabelle Grillier-Vuissoz
Summary: This study investigated the role of CLDN1 in triple-negative breast cancer (TNBC) and found that CLDN1 can increase the sensitivity of TNBC cells to chemotherapy drugs. The findings support the use of CLDN1 as a predictive marker for chemotherapy response in TNBC.
Article
Oncology
Hossein Ghahremani, Saeedeh Nabati, Hanieh Tahmori, Tahmineh Peirouvi, Majid Sirati-Sabet, Siamak Salami
Summary: The study demonstrated that glucose restriction and bHB enrichment can reduce stemness markers and decrease in vitro migration of ovarian cancer cells. Glucose restriction significantly lowered ATP levels in both cell lines, while bHB enrichment partially compensated for ATP levels in one cell line.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Hematology
Fatemeh Kiani Nodeh, Ehteramolsadat Hosseini, Mehran Ghasemzadeh
Summary: The study found that gamma irradiation can increase cytosolic ROS generation in two distinct phases, and the longer storage time, the more obvious the oxidant stress. Furthermore, the observation of early P-selectin increments and increased PS exposure in longer-stored PLTs suggests a link between ROS generation and PLT activation that warrants further investigation.
Review
Immunology
Mehran Ghasemzadeh, Alireza Ghasemzadeh, Ehteramolsadat Hosseini
Summary: The COVID-19 virus disrupts immune responses by interfering with the cytolytic antiviral effects of NK cells and activating immune cells, leading to a dangerous cytokine storm. Improving the cytotoxicity of NK cells may benefit treatment protocols, and the clonal expansion of activating NK memory cells holds promise for vaccine development and NK cell therapy in COVID-19.
Letter
Oncology
Hossein Ghahremani, Siamak Salami
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2021)
Review
Cell Biology
Ehteramolsadat Hosseini, Fatemeh Kianinodeh, Mehran Ghasemzadeh
Summary: Irradiation of platelet products, including gamma-irradiation and UV-illumination, is mainly used to prevent TA-GvHD and transmission of infections. Studies have shown that irradiation may induce PSL and reduce platelet efficiency, warranting further research to enhance the safety and efficacy of pathogen reduction technologies.
Article
Hematology
Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh, Simone M. Schoenwaelder
Summary: Comparative analysis of platelets stored under continuous agitation and manual mixing conditions revealed that manually-mixed platelets exhibited higher levels of GPVI expression and adhesion/spreading capacity, indicating a role for biomechanical forces in modulating GPVI-dependent function. Additionally, lower GPVI expression in continuously-agitated platelets may be attributed to shear forces induced by agitation, leading to attenuated platelet adhesion/spreading capabilities during storage.
THROMBOSIS JOURNAL
(2022)
Article
Immunology
Ehteramolsadat Hosseini, Ehsan Sarraf Kazerooni, Azita Azarkeivan, Zohreh Sharifi, Majid Shahabi, Mehran Ghasemzadeh
Summary: HLA-E polymorphism affects HCV infection and treatment in major thalassemia patients. The HLA-E*01:03 allele increases susceptibility to HCV infection, while the HLA-E*01:03/*01:03 genotype is associated with higher resistance to HCV treatment.
Article
Biochemistry & Molecular Biology
Leila Oudbor, Zohreh Mokhtari, Sanaz Dastghaib, Pooneh Mokarram, Huda Fatima Rajani, Mahdi Barazesh, Siamak Salami
Summary: This study evaluated the effects of stevia extract on gene expression in diabetic rats and pancreatic cell lines. The findings indicate that stevia extract upregulates antioxidative defense genes and downregulates genes associated with cell death, leading to clinical improvements in diabetes.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Hematology
Mehran Ghasemzadeh, Javad Ahmadi, Ehteramolsadat Hosseini
Summary: Platelet-leukocyte crosstalk plays a vital role in thrombosis and inflammation. COVID-19, a life-threatening disease, is characterized by intensified interaction between platelets and leukocytes, exacerbating inflammation and thrombosis.
THROMBOSIS RESEARCH
(2022)
Correction
Hematology
Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh, Simone M. Schoenwaelder
THROMBOSIS JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Javad Ahmadi, Ehteramolsadat Hosseini, Faranak Kargar, Mehran Ghasemzadeh
Summary: This study reveals that activated platelets in patients with coronary artery disease (CAD) have higher levels of platelet-borne transforming growth factor-beta 1 (TGF-beta 1), which is correlated with the expression of pro-inflammatory molecules. This suggests that platelet-borne TGF-beta 1 plays a significant role in the pathogenesis of CAD.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Biochemistry & Molecular Biology
Ehteramolsadat Hosseini, Fatemeh Kiani Nodeh, Mehran Ghasemzadeh
Summary: This study investigated the effects of gamma irradiation on platelets and found that it induces platelet mitochondrial dysfunction and increases the expression of pro-apoptotic proteins. However, gamma irradiation did not significantly affect platelet apoptosis or viability. Future research on supplementing ROS scavengers or antioxidants to improve the quality of irradiated platelets during storage may be of interest.
Article
Immunology
Ehteramolsadat Hosseini, Arefeh Minagar, Mehran Ghasemzadeh, Ali Arabkhazaeli, Alireza Ghasemzadeh
Summary: HLA-E polymorphisms affect susceptibility and severity of COVID-19. HLA-E*01:01 genotype provides better protection against COVID-19, while HLA-E*01:03 genotype is associated with more severe cases of the disease.
Article
Biology
Sima Hajiahmadi, Shahrokh Lorzadeh, Rosa Iranpour, Saeed Karima, Masoumeh Rajabibazl, Zahra Shahsavari, Saeid Ghavami
Summary: Glioblastoma multiforme (GBM) is a deadly brain tumor and current chemotherapy strategies are not very effective. In this study, a combination therapy of temozolomide (TMZ), simvastatin, and acetylshikonin was found to induce more cell death in GBM cell lines by damaging the mitochondria. In addition, inhibiting autophagy sensitized GBM cells to the triple combination treatment. This research may open new avenues for the treatment of GBM patients in the long term.
Article
Biology
Seyedeh Zahra Shahrokhi, Fatemeh Soghra Karami Tehrani, Siamak Salami
Summary: The study demonstrated that biliverdin has a significant role in cell apoptosis in breast cancer cells, and inhibiting biliverdin reductase can enhance the apoptotic effect of biliverdin.