Pharmacogenomics of methadone maintenance treatment

Association of OPRM1 and COMT Single-Nucleotide Polymorphisms With Hospital Length of Stay and Treatment of Neonatal Abstinence Syndrome

(2013) Elisha M. Wachman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PXR Polymorphisms Interacted With CYP2B6 Polymorphisms on Methadone Metabolites

(2013) Hui-Ju Tsai et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

In vivoinduction of P-glycoprotein expression at the mouse blood-brain barrier: an intracerebral microdialysis study

(2013) Gary N. Y. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction

(2013) Orna Levran et al.   PHARMACOGENOMICS

Functional Impact of ABCB1 Variants on Interactions between P-Glycoprotein and Methadone

(2013) Chin-Chuan Hung et al.   PLoS One

Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?

(2013) Elisa Mura et al.   Journal of Pain Research

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance

(2013) Ulrich M. Zanger et al.   Frontiers in Genetics

Long term outcomes of pharmacological treatments for opioid dependence: does methadone still lead the pack?

(2012) Maria Paz Garcia-Portilla et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Corrected QT interval during treatment with methadone and buprenorphine—Relation to doses and serum concentrations

(2012) Marianne Stallvik et al.   DRUG AND ALCOHOL DEPENDENCE

Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients

(2012) Sheng-Chang Wang et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The genetics of the opioid system and specific drug addictions

(2012) Orna Levran et al.   HUMAN GENETICS

Response to Methadone Maintenance Treatment is Associated with the MYOCD and GRM6 Genes

(2012) Francina Fonseca et al.   Molecular Diagnosis & Therapy

Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels

(2012) Maria Dobrinas et al.   Pharmacogenetics and Genomics

UGT2B7genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients

(2012) Jia-Ni Tian et al.   PHARMACOGENOMICS

Pharmacogenomics of opioids and perioperative pain management

(2012) Senthilkumar Sadhasivam et al.   PHARMACOGENOMICS

CYP2B6SNPs are associated with methadone dose required for effective treatment of opioid addiction

(2011) Orna Levran et al.   ADDICTION BIOLOGY

A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability

(2011) Peng Huang et al.   BIOCHEMICAL JOURNAL

Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects

(2011) Eloise A. Gelston et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

(2011) Lay Kek Teh et al.   Drug Metabolism and Pharmacokinetics

Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)

(2011) Ichiro Ieiri   Drug Metabolism and Pharmacokinetics

CYP2B6 Polymorphisms Influence the Plasma Concentration and Clearance of the Methadone S-Enantiomer

(2011) Sheng-Chang Wang et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients

(2011) Chia-Hui Chen et al.   PHARMACOGENOMICS

Impact of genetic polymorphisms inABCB1,CYP2B6,OPRM1,ANKK1andDRD2genes on methadone therapy in Han Chinese patients

(2011) Chin-Chuan Hung et al.   PHARMACOGENOMICS

An update on ABCB1 pharmacogenetics: insights from a 3D model into the location and evolutionary conservation of residues corresponding to SNPs associated with drug pharmacokinetics

(2011) S J Wolf et al.   PHARMACOGENOMICS JOURNAL

Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment

(2011) O Levran et al.   PHARMACOGENOMICS JOURNAL

Contribution of Cytochrome P450 and ABCB1 Genetic Variability on Methadone Pharmacokinetics, Dose Requirements, and Response

(2011) Francina Fonseca et al.   PLoS One

CYP2B6 and OPRM1 gene variations predict methadone-related deaths

(2010) Hannah Bunten et al.   ADDICTION BIOLOGY

Rates and correlates of mortality amongst heroin users: Findings from the Australian Treatment Outcome Study (ATOS), 2001–2009

(2010) Shane Darke et al.   DRUG AND ALCOHOL DEPENDENCE

A KCNJ6 (Kir3.2, GIRK2) gene polymorphism modulates opioid effects on analgesia and addiction but not on pupil size

(2010) Jörn Lötsch et al.   Pharmacogenetics and Genomics

β-Arrestin2 influences the response to methadone in opioid-dependent patients

(2010) B Oneda et al.   PHARMACOGENOMICS JOURNAL

Methadone Pharmacokinetics Are Independent of Cytochrome P4503A (CYP3A) Activity and Gastrointestinal Drug Transport

(2009) Evan D. Kharasch et al.   ANESTHESIOLOGY

Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: Risk factors and lives saved

(2009) Louisa Degenhardt et al.   DRUG AND ALCOHOL DEPENDENCE

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

(2009) Evan D. Kharasch et al.   DRUG AND ALCOHOL DEPENDENCE

Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)

(2009) Nicolas Tournier et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Differential Involvement of P-Glycoprotein (ABCB1) in Permeability, Tissue Distribution, and Antinociceptive Activity of Methadone, Buprenorphine, and Diprenorphine: In Vitro and In Vivo Evaluation

(2009) Hazem E. Hassan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution

(2009) Alexandra Doehring et al.   Pharmacogenetics and Genomics

Association between KCNJ6 (GIRK2) Gene Polymorphisms and Postoperative Analgesic Requirements after Major Abdominal Surgery

(2009) Daisuke Nishizawa et al.   PLoS One

Exposure to opioid maintenance treatment reduces long-term mortality

(2008) Amy Gibson et al.   ADDICTION

Role of CYP3A5 in Abnormal Clearance of Methadone

(2008) Salvatore De Fazio et al.   ANNALS OF PHARMACOTHERAPY

Role of active metabolites in the use of opioids

(2008) Janet K. Coller et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

BDNFvariability in opioid addicts and response to methadone treatment: preliminary findings

(2008) R. de Cid et al.   GENES BRAIN AND BEHAVIOR

ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence

(2008) Orna Levran et al.   HUMAN MOLECULAR GENETICS

Substrate-Dependent Effects of Human ABCB1 Coding Polymorphisms

(2008) J. M. Gow et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment

(2008) Séverine Crettol et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA

No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement

(2007) S Crettol et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS